Zobrazeno 1 - 10
of 706
pro vyhledávání: '"Knight, JC"'
Autor:
Cano-Gamez, E, Burnham, KL, Goh, C, Allcock, A, Malick, ZH, Overend, L, Kwok, A, Smith, DA, Peters-Sengers, H, Antcliffe, D, GAinS Investigators, McKechnie, S, Scicluna, BP, Van der Poll, T, Gordon, AC, Hinds, CJ, Davenport, EE, Knight, JC, Webster, N, Galley, H, Taylor, J, Hall, S, Addison, J, Roughton, S, Tennant, H, Guleri, A, Waddington, N, Arawwawala, D, Durcan, J, Short, A, Swan, K, Williams, S, Smolen, S, Mitchell-Inwang, C, Gordon, T, Errington, E, Templeton, M, Venatesh, P, Ward, G, McCauley, M, Baudouin, S, Higham, C, Soar, J, Grier, S, Hall, E, Brett, S, Kitson, D, Wilson, R, Mountford, L, Moreno, J, Hall, P, Hewlett, J, Garrard, C, Millo, J, Young, D, Hutton, P, Parsons, P, Smiths, A, Faras-Arraya, R, Raymode, P, Thompson, J, Bowrey, S, Kazembe, S, Rich, N, Andreou, P, Hales, D, Roberts, E, Fletcher, S, Rosbergen, M, Glister, G, Cuesta, JM, Bion, J, Millar, J, Perry, EJ, Willis, H, Mitchell, N, Ruel, S, Carrera, R, Wilde, J, Nilson, A, Lees, S, Kapila, A, Jacques, N, Atkinson, J, Brown, A, Prowse, H, Krige, A, Bland, M, Bullock, L, Harrison, D, Mills, G, Humphreys, J, Armitage, K, Laha, S, Baldwin, J, Walsh, A, Doherty, N, Drage, S, Ortiz-Ruiz de Gordoa, L, Lowes, S, Walsh, H, Calder, V, Swan, C, Payne, H, Higgins, D, Andrews, S, Mappleback, S, Hind, C, Watson, D, McLees, E, Purdy, A, Stotz, M, Ochelli-Okpue, A, Bonner, S, Whitehead, I, Hugil, K, Goodridge, V, Cawthor, L, Kuper, M, Pahary, S, Bellingan, G, Marshall, R, Montgomery, H, Ryu, JH, Bercades, G, Boluda, S, Bentley, A, Mccalman, K, Jefferies, F, Knight, J, Davenport, E, Burnham, K, Maugeri, N, Radhakrishnan, J, Mi, Y
Publikováno v:
Science translational medicine, 14(669):eabq4433. American Association for the Advancement of Science
Dysregulated host responses to infection can lead to organ dysfunction and sepsis, causing millions of global deaths each year. To alleviate this burden, improved prognostication and biomarkers of response are urgently needed. We investigated the use
Autor:
Whyte, CS, Simpson, M, Morrow, GB, Wallace, CA, Mentzer, AJ, Knight, JC, Shapiro, S, Curry, N, Bagot, CN, Watson, H, Cooper, JG, Mutch, NJ
Publikováno v:
Journal of thrombosis and haemostasis : JTH. 20(10)
Background Severe COVID-19 disease is associated with thrombotic complications and extensive fibrin deposition. This study investigates whether the hemostatic complications in COVID-19 disease arise due to dysregulation of the fibrinolytic system. Me
Autor:
Milighetti, M, Peng, Y, Tan, C, Mark, M, Nageswaran, G, Byrne, S, Ronel, T, Peacock, T, Mayer, A, Chandran, A, Rosenheim, J, Whelan, M, Yao, X, Liu, G, Felce, SL, Dong, T, Mentzer, AJ, Knight, JC, Balloux, F, Greenstein, E, Reich-Zeliger, S, Pade, C, Gibbons, JM, Semper, A, Brooks, T, Otter, A, Altmann, DM, Boyton, RJ, Maini, MK, McKnight, A, Manisty, C, Treibel, TA, Moon, JC, COVIDsortium Investigators, Noursadeghi, M, Chain, B
Publikováno v:
iScience. :106937
T cell responses precede antibody and may provide early control of infection. We analyzed the clonal basis of this rapid response following SARS-COV-2 infection. We applied T cell receptor (TCR) sequencing to define the trajectories of individual T c
Autor:
Tomic, A, Skelly, DT, Ogbe, A, O’Connor, D, Pace, M, Adland, E, Alexander, F, Ali, M, Allott, K, Azim Ansari, M, Belij-Rammerstorfer, S, Bibi, S, Blackwell, L, Brown, A, Brown, H, Cavell, B, Clutterbuck, EA, de Silva, T, Eyre, D, Lumley, S, Flaxman, A, Grist, J, Hackstein, C-P, Halkerston, R, Harding, AC, Hill, J, James, T, Jay, C, Johnson, SA, Kronsteiner, B, Lie, Y, Linder, A, Longet, S, Marinou, S, Matthews, PC, Mellors, J, Petropoulos, C, Rongkard, P, Sedik, C, Silva-Reyes, L, Smith, H, Stockdale, L, Taylor, S, Thomas, S, Tipoe, T, Turtle, L, Vieira, VA, Wrin, T, Stafford, L, Abuelgasim, H, Alhussni, A, Arancibia-Cárcamo, CV, Borak, M, Cutteridge, J, Deeks, A, Denly, L, Dimitriadis, S, Fassih, S, Foord, T, Fordwoh, T, Holmes, J, Horsington, B, Kerneis, S, Kim, D, Lillie, K, Morrow, J, O’Donnell, D, Ritter, TG, Simmons, B, Taylor, A, Thomas, SR, Warren, Y, Watson, AJR, Weeks, E, Wilson, R, Young, R, Duncan, CJA, Moore, SC, Payne, R, Richter, A, Rowland-Jones, S, Mentzer, AJ, Cassar, MP, Dong, T, Fries, A, Gilbert-Jaramillo, J, Ho, L-P, Knight, JC, Neubauer, S, Peng, Y, Petousi, N, Raman, B, Talbot, NP, Pollard, AJ, Lambe, T, Conlon, CP, Jeffery, K, Travis, S, Goulder, P, Frater, J, Carroll, MW, James, WS, Klenerman, P, Barnes, E, Dold, C, Dunachie, SJ
The trajectories of acquired immunity to severe acute respiratory syndrome coronavirus 2 infection are not fully understood. We present a detailed longitudinal cohort study of UK healthcare workers prior to vaccination, presenting April-June 2020 wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::47b9f7d8b380d35797b218796dd35d21
https://eprints.whiterose.ac.uk/184702/1/s41467-022-28898-1.pdf
https://eprints.whiterose.ac.uk/184702/1/s41467-022-28898-1.pdf
Autor:
Skelly, DT, Harding, AC, Gilbert-Jaramillo, J, Knight, ML, Longet, S, Brown, A, Adele, S, Adland, E, Brown, H, Chinnakannan, S, Donnison, T, Ali, M, Rongkard, P, Pace, M, Zacharopoulou, P, Robinson, N, Csala, A, De Lara, C, Hutchings, CL, Mehta, H, Lee, LN, Edmans, M, Hackstein, C-P, Phalora, P, Li, W, Phillips, E, Malone, T, Ogbe, A, Jay, C, Tipoe, T, Tipton, T, Stafford, L, Mentzer, AJ, Johnson, SA, Amini, A, Marjot, T, Dimitriadis, S, Simmons, B, Deeks, A, Kerneis, S, Abuelgasim, H, Wilson, R, Thomas, SR, Watson, A, Alhussni, A, Cutteridge, J, Weeks, E, Denly, L, Lillie, K, Holmes, J, Matthews, PC, O’Donnell, D, Tan, TK, Schimanski, L, Huang, K-YA, Rijal, P, Turtle, L, de Silva, T, Richter, A, Duncan, CJA, Payne, RP, Moore, SC, Knight, JC, Cassar, MP, Raman, B, Neubauer, S, Fries, A, Talbot, NP, Petousi, N, Ho, L-P, Peng, Y, Dong, T, Camara, S, Marinou, S, Linder, A, Adlou, S, Kasanyinga, M, Bridges-Webb, A, Hill, J, Silva-Reyes, L, Blackwell, L, Frater, J, Goulder, P, Conlon, CP, Jeffery, K, Dold, C, Pollard, AJ, Sigal, A, de Oliveira, T, Townsend, AR, Klenerman, P, Dunachie, SJ, Barnes, E, Carroll, MW, James, WS
Publikováno v:
Nature Communications
The extent to which immune responses to natural infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and immunization with vaccines protect against variants of concern (VOC) is of increasing importance. Accordingly, here we ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::ce39df3af5380f43937f7f4638fd58b6
https://eprints.whiterose.ac.uk/177331/1/s41467-021-25167-5.pdf
https://eprints.whiterose.ac.uk/177331/1/s41467-021-25167-5.pdf
Autor:
Gilchrist, JJ, Rautanen, A, Fairfax, BP, Mills, TC, Naranbhai, V, Trochet, H, Pirinen, M, Muthumbi, E, Mwarumba, S, Njuguna, P, Mturi, N, Msefula, CL, Gondwe, EN, MacLennan, JM, Chapman, SJ, Molyneux, ME, Knight, JC, Spencer, CCA, Williams, TN, MacLennan, CA, Scott, JAG, Hill, AVS
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications
Nature Communications
Nontyphoidal Salmonella (NTS) is a major cause of bacteraemia in Africa. The disease typically affects HIV-infected individuals and young children, causing substantial morbidity and mortality. Here we present a genome-wide association study (180 case
Autor:
Marculescu, C, Lakshminarayanan, A, Gault, J, Knight, JC, Folkes, LK, Spink, T, Robinson, CV, Vallis, K, Davis, BG, Cornelissen, B
Site-selective labelling of antibodies (Abs) can circumvent problems from heterogeneity of conventional conjugation. Here, we evaluate the industrially-applied chemoenzymatic ‘Q-tag’ strategy based on transglutaminase-mediated (TGase) amide-bond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::47cfeba6e94132032a884cad54760a1d
https://ora.ox.ac.uk/objects/uuid:183a8b49-8ec5-4e3b-90fe-c8a2ca670dcf
https://ora.ox.ac.uk/objects/uuid:183a8b49-8ec5-4e3b-90fe-c8a2ca670dcf
Autor:
Roberts, AR, Vecellio, M, Chen, L, Ridley, A, Cortes, A, Knight, JC, Bowness, P, Cohen, CJ, Wordsworth, BP
Publikováno v:
Annals of the Rheumatic Diseases
Objectives To explore the functional basis for the association between ankylosing spondylitis (AS) and single-nucleotide polymorphisms (SNPs) in the IL23R-IL12RB2 intergenic region. Methods We performed conditional analysis on genetic association dat
Autor:
Ormondroyd, E, Mackley, MP, Blair, E, Craft, J, Knight, JC, Taylor, JC, Taylor, J, Watkins, H
Publikováno v:
Genetics in Medicine
PurposeApproaches to secondary findings in genome sequencing (GS) are unresolved. In the United Kingdom, GS is now routinely available through the 100,000 Genomes Project, which offers participants feedback of limited secondary findings. MethodsIn Ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::687ce418f6acb0db18397dae6c1c568a
https://doi.org/10.1038/gim.2017.157
https://doi.org/10.1038/gim.2017.157
Autor:
Knight, JC
This book describes the remarkable progress which has been made in defining the extent and nature of human genetic variation, and its many consequences for us as individuals and in understanding human origins. A mix of cutting-edge and landmark studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a497e0c546e0e66b0bd7ec680fbaf8cb
https://ora.ox.ac.uk/objects/uuid:c52c66cc-6343-4f71-8c2b-02000cab0e33
https://ora.ox.ac.uk/objects/uuid:c52c66cc-6343-4f71-8c2b-02000cab0e33