Novel Long Noncoding RNA HEAT4 Affects Monocyte Subtypes, Reducing Inflammation and Promoting Vascular Healing.

Autor: Kneuer JM; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Germany (J.M.K., I.A.G., M.W., S.E., T.M., M.N.M.-W., A.K., K.E.K., V.F., S.G., U.L., J.-N.B.).; Central German Heart Alliance (J.M.K., I.A.G., M.W., S.E., T.M., M.N.M.-W., A.K., K.E.K., V.F., S.G., H.T., U.L., J.-N.B.)., Grajek IA; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Germany (J.M.K., I.A.G., M.W., S.E., T.M., M.N.M.-W., A.K., K.E.K., V.F., S.G., U.L., J.-N.B.).; Central German Heart Alliance (J.M.K., I.A.G., M.W., S.E., T.M., M.N.M.-W., A.K., K.E.K., V.F., S.G., H.T., U.L., J.-N.B.)., Winkler M; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Germany (J.M.K., I.A.G., M.W., S.E., T.M., M.N.M.-W., A.K., K.E.K., V.F., S.G., U.L., J.-N.B.).; Central German Heart Alliance (J.M.K., I.A.G., M.W., S.E., T.M., M.N.M.-W., A.K., K.E.K., V.F., S.G., H.T., U.L., J.-N.B.)., Erbe S; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Germany (J.M.K., I.A.G., M.W., S.E., T.M., M.N.M.-W., A.K., K.E.K., V.F., S.G., U.L., J.-N.B.).; Central German Heart Alliance (J.M.K., I.A.G., M.W., S.E., T.M., M.N.M.-W., A.K., K.E.K., V.F., S.G., H.T., U.L., J.-N.B.)., Meinecke T; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Germany (J.M.K., I.A.G., M.W., S.E., T.M., M.N.M.-W., A.K., K.E.K., V.F., S.G., U.L., J.-N.B.).; Central German Heart Alliance (J.M.K., I.A.G., M.W., S.E., T.M., M.N.M.-W., A.K., K.E.K., V.F., S.G., H.T., U.L., J.-N.B.)., Weiss R; Institute of Clinical Immunology, University of Leipzig, Germany (R.W.)., Garfias-Veitl T; Department of Cardiology and Pneumology, University Medical Center of Göttingen (UMG), Germany (T.G.-V., S.v.H.).; German Center for Cardiovascular Research (DZHK), Partner Site Göttingen, Germany (T.G.-V., S.v.H.)., Sheikh BN; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Germany (B.N.S.)., König AC; German Research Center for Environmental Health (GmbH), Metabolomics and Proteomics Core, Helmholtz Zentrum München, Germany (A.-C.K.)., Möbius-Winkler MN; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Germany (J.M.K., I.A.G., M.W., S.E., T.M., M.N.M.-W., A.K., K.E.K., V.F., S.G., U.L., J.-N.B.).; Central German Heart Alliance (J.M.K., I.A.G., M.W., S.E., T.M., M.N.M.-W., A.K., K.E.K., V.F., S.G., H.T., U.L., J.-N.B.)., Kogel A; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Germany (J.M.K., I.A.G., M.W., S.E., T.M., M.N.M.-W., A.K., K.E.K., V.F., S.G., U.L., J.-N.B.).; Central German Heart Alliance (J.M.K., I.A.G., M.W., S.E., T.M., M.N.M.-W., A.K., K.E.K., V.F., S.G., H.T., U.L., J.-N.B.)., Kresoja KP; Department of Cardiology, Heart Center at University of Leipzig, Germany (K.-P.K., S.R., H.T., P.L.).; Department of Cardiology, Universitätsmedizin Johannes Gutenberg-University, Mainz, Germany (K.-P.K., S.R., P.L.)., Rosch S; Department of Cardiology, Heart Center at University of Leipzig, Germany (K.-P.K., S.R., H.T., P.L.).; Department of Cardiology, Universitätsmedizin Johannes Gutenberg-University, Mainz, Germany (K.-P.K., S.R., P.L.)., Kokot KE; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Germany (J.M.K., I.A.G., M.W., S.E., T.M., M.N.M.-W., A.K., K.E.K., V.F., S.G., U.L., J.-N.B.).; Central German Heart Alliance (J.M.K., I.A.G., M.W., S.E., T.M., M.N.M.-W., A.K., K.E.K., V.F., S.G., H.T., U.L., J.-N.B.)., Filipova V; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Germany (J.M.K., I.A.G., M.W., S.E., T.M., M.N.M.-W., A.K., K.E.K., V.F., S.G., U.L., J.-N.B.).; Central German Heart Alliance (J.M.K., I.A.G., M.W., S.E., T.M., M.N.M.-W., A.K., K.E.K., V.F., S.G., H.T., U.L., J.-N.B.)., Gaul S; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Germany (J.M.K., I.A.G., M.W., S.E., T.M., M.N.M.-W., A.K., K.E.K., V.F., S.G., U.L., J.-N.B.).; Central German Heart Alliance (J.M.K., I.A.G., M.W., S.E., T.M., M.N.M.-W., A.K., K.E.K., V.F., S.G., H.T., U.L., J.-N.B.)., Thiele H; Central German Heart Alliance (J.M.K., I.A.G., M.W., S.E., T.M., M.N.M.-W., A.K., K.E.K., V.F., S.G., H.T., U.L., J.-N.B.).; Department of Cardiology, Heart Center at University of Leipzig, Germany (K.-P.K., S.R., H.T., P.L.)., Lurz P; Department of Cardiology, Heart Center at University of Leipzig, Germany (K.-P.K., S.R., H.T., P.L.).; Department of Cardiology, Universitätsmedizin Johannes Gutenberg-University, Mainz, Germany (K.-P.K., S.R., P.L.)., von Haehling S; Department of Cardiology and Pneumology, University Medical Center of Göttingen (UMG), Germany (T.G.-V., S.v.H.).; German Center for Cardiovascular Research (DZHK), Partner Site Göttingen, Germany (T.G.-V., S.v.H.)., Speer T; Medizinische Klinik 4: Nephrologie, Universitätsklinikum Frankfurt, Frankfurt am Main, Germany (T.S.).; Else Kroener-Fresenius Center for Nephrological Research, Goethe University, Frankfurt, Germany (T.S.)., Laufs U; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Germany (J.M.K., I.A.G., M.W., S.E., T.M., M.N.M.-W., A.K., K.E.K., V.F., S.G., U.L., J.-N.B.).; Central German Heart Alliance (J.M.K., I.A.G., M.W., S.E., T.M., M.N.M.-W., A.K., K.E.K., V.F., S.G., H.T., U.L., J.-N.B.)., Boeckel JN; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Germany (J.M.K., I.A.G., M.W., S.E., T.M., M.N.M.-W., A.K., K.E.K., V.F., S.G., U.L., J.-N.B.).; Central German Heart Alliance (J.M.K., I.A.G., M.W., S.E., T.M., M.N.M.-W., A.K., K.E.K., V.F., S.G., H.T., U.L., J.-N.B.).

Publikováno v: Circulation [Circulation] 2024 Oct; Vol. 150 (14), pp. 1101-1120. Date of Electronic Publication: 2024 Jul 15.

NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart.

Autor: Müller M; Kardiogenetikzentrum Heidelberg, University Hospital of Heidelberg, Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Berlin, Germany.; Clinic for General and Interventional Cardiology/ Angiology, Herz- und Diabeteszentrum NRW, University Hospital of the Ruhr-Universität Bochum, Bad Oeynhausen, Germany., Eghbalian R; Kardiogenetikzentrum Heidelberg, University Hospital of Heidelberg, Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Berlin, Germany., Boeckel JN; Clinic and Polyclinic for Cardiology, University of Leipzig, Leipzig, Germany., Frese KS; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Berlin, Germany.; Department of Medicine III, University of Heidelberg, Heidelberg, Germany., Haas J; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Berlin, Germany.; Department of Medicine III, University of Heidelberg, Heidelberg, Germany., Kayvanpour E; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Berlin, Germany.; Department of Medicine III, University of Heidelberg, Heidelberg, Germany., Sedaghat-Hamedani F; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Berlin, Germany.; Department of Medicine III, University of Heidelberg, Heidelberg, Germany., Lackner MK; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Berlin, Germany.; Department of Medicine III, University of Heidelberg, Heidelberg, Germany., Tugrul OF; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Berlin, Germany.; Department of Medicine III, University of Heidelberg, Heidelberg, Germany., Ruppert T; CFMP, Core Facility for Mass Spectrometry & Proteomics at ZMBH, Heidelberg University, Heidelberg, Germany.; ZMBH, Center for Molecular Biology, Heidelberg University, Heidelberg, Germany., Tappu R; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Berlin, Germany.; Department of Medicine III, University of Heidelberg, Heidelberg, Germany., Martins Bordalo D; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Berlin, Germany.; Department of Medicine III, University of Heidelberg, Heidelberg, Germany., Kneuer JM; Clinic and Polyclinic for Cardiology, University of Leipzig, Leipzig, Germany., Piekarek A; Department of Medicine III, University of Heidelberg, Heidelberg, Germany., Herch S; Department of Medicine III, University of Heidelberg, Heidelberg, Germany., Schudy S; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Berlin, Germany.; Department of Medicine III, University of Heidelberg, Heidelberg, Germany., Keller A; Clinical Bioinformatics, Saarland University, Saarbrücken, Germany.; Department of Neurology and Neurological Sciences, Stanford University Medical School, Stanford, CA, USA., Grammes N; Clinical Bioinformatics, Saarland University, Saarbrücken, Germany.; Department of Neurology and Neurological Sciences, Stanford University Medical School, Stanford, CA, USA., Bischof C; Clinic for General and Interventional Cardiology/ Angiology, Herz- und Diabeteszentrum NRW, University Hospital of the Ruhr-Universität Bochum, Bad Oeynhausen, Germany., Klinke A; Clinic for General and Interventional Cardiology/ Angiology, Herz- und Diabeteszentrum NRW, University Hospital of the Ruhr-Universität Bochum, Bad Oeynhausen, Germany., Cardoso-Moreira M; ZMBH, Center for Molecular Biology, Heidelberg University, Heidelberg, Germany., Kaessmann H; ZMBH, Center for Molecular Biology, Heidelberg University, Heidelberg, Germany., Katus HA; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Berlin, Germany.; Department of Medicine III, University of Heidelberg, Heidelberg, Germany., Frey N; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Berlin, Germany.; Department of Medicine III, University of Heidelberg, Heidelberg, Germany., Steinmetz LM; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Berlin, Germany.; Stanford Genome Technology Center, Stanford University Medical School, Stanford, CA, USA., Meder B; Kardiogenetikzentrum Heidelberg, University Hospital of Heidelberg, Heidelberg, Germany. benjamin.meder@med.uni-heidelberg.de.; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Berlin, Germany. benjamin.meder@med.uni-heidelberg.de.; Stanford Genome Technology Center, Stanford University Medical School, Stanford, CA, USA. benjamin.meder@med.uni-heidelberg.de.

Publikováno v: Nature communications [Nat Commun] 2022 Oct 20; Vol. 13 (1), pp. 6209. Date of Electronic Publication: 2022 Oct 20.

Reduction of A-to-I RNA editing in the failing human heart regulates formation of circular RNAs.

Autor: Kokot KE; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Liebigstrasse 20, Leipzig, Germany., Kneuer JM; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Liebigstrasse 20, Leipzig, Germany., John D; Institute for Cardiovascular Regeneration, Goethe-University Hospital, Theodor Stern Kai 7, Frankfurt, Germany.; German Centre for Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany., Rebs S; Institute of Pharmacology and Toxicology, Versbacher-Str. 9, Würzburg, Germany.; Heartcenter - Clinic for Cardiology and Pneumology, University Medicine Goettingen, Robert-Koch-Str. 40, Göttingen, Germany.; German Centre for Cardiovascular Research (DZHK), Partner site Göttingen, Göttingen, Germany., Möbius-Winkler MN; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Liebigstrasse 20, Leipzig, Germany., Erbe S; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Liebigstrasse 20, Leipzig, Germany., Müller M; Department of General and Interventional Cardiology/Angiology, Ruhr University of Bochum, Heart-and Diabetes Center North Rhine-Westphalia, Bad Oeynhausen, Germany., Andritschke M; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Liebigstrasse 20, Leipzig, Germany., Gaul S; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Liebigstrasse 20, Leipzig, Germany., Sheikh BN; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany., Haas J; Department of Internal Medicine III, University of Heidelberg, Heidelberg, Germany.; German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg, Heidelberg, Germany., Thiele H; Heart Center Leipzig at University of Leipzig and Leipzig Heart Institute, Leipzig, Germany., Müller OJ; Department of Internal Medicine III, University of Kiel, Kiel, Germany.; German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Kiel, Germany., Hille S; Department of Internal Medicine III, University of Kiel, Kiel, Germany.; German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Kiel, Germany., Leuschner F; Department of Internal Medicine III, University of Heidelberg, Heidelberg, Germany.; German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg, Heidelberg, Germany., Dimmeler S; Institute for Cardiovascular Regeneration, Goethe-University Hospital, Theodor Stern Kai 7, Frankfurt, Germany.; German Centre for Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany., Streckfuss-Bömeke K; Institute of Pharmacology and Toxicology, Versbacher-Str. 9, Würzburg, Germany.; Heartcenter - Clinic for Cardiology and Pneumology, University Medicine Goettingen, Robert-Koch-Str. 40, Göttingen, Germany.; German Centre for Cardiovascular Research (DZHK), Partner site Göttingen, Göttingen, Germany., Meder B; Department of Internal Medicine III, University of Heidelberg, Heidelberg, Germany.; German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg, Heidelberg, Germany., Laufs U; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Liebigstrasse 20, Leipzig, Germany., Boeckel JN; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Liebigstrasse 20, Leipzig, Germany. Boeckel@medizin.uni-leipzig.de.

Publikováno v: Basic research in cardiology [Basic Res Cardiol] 2022 Jun 23; Vol. 117 (1), pp. 32. Date of Electronic Publication: 2022 Jun 23.

SLM2 Is A Novel Cardiac Splicing Factor Involved in Heart Failure due to Dilated Cardiomyopathy.

Autor: Boeckel JN; Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, D-69120 Heidelberg, Germany; Klinik und Poliklinik für Kardiologie, Universitätskrankenhaus Leipzig, D-04103 Leipzig, Germany., Möbius-Winkler M; Klinik und Poliklinik für Kardiologie, Universitätskrankenhaus Leipzig, D-04103 Leipzig, Germany., Müller M; Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, D-69120 Heidelberg, Germany; German Center for Cardiovascular Research (DZHK), Partner site Heidelberg, D-69120 Heidelberg, Germany; Clinic for General and Interventional Cardiology/Angiology, Herz- und Diabeteszentrum NRW, Ruhr-Universität Bochum, D-32545 Bad Oeynhausen, Germany., Rebs S; Department of Cardiology and Pneumology, University Hospital, Georg-August University Goettingen, D-37075 Goettingen, Germany; German Center for Cardiovascular Research (DZHK), Partner site Goettingen, D-37075 Goettingen, Germany., Eger N; Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, D-69120 Heidelberg, Germany., Schoppe L; Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, D-69120 Heidelberg, Germany., Tappu R; Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, D-69120 Heidelberg, Germany., Kokot KE; Klinik und Poliklinik für Kardiologie, Universitätskrankenhaus Leipzig, D-04103 Leipzig, Germany., Kneuer JM; Klinik und Poliklinik für Kardiologie, Universitätskrankenhaus Leipzig, D-04103 Leipzig, Germany., Gaul S; Klinik und Poliklinik für Kardiologie, Universitätskrankenhaus Leipzig, D-04103 Leipzig, Germany., Bordalo DM; Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, D-69120 Heidelberg, Germany; German Center for Cardiovascular Research (DZHK), Partner site Heidelberg, D-69120 Heidelberg, Germany., Lai A; Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, D-69120 Heidelberg, Germany; German Center for Cardiovascular Research (DZHK), Partner site Heidelberg, D-69120 Heidelberg, Germany., Haas J; Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, D-69120 Heidelberg, Germany; German Center for Cardiovascular Research (DZHK), Partner site Heidelberg, D-69120 Heidelberg, Germany., Ghanbari M; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, D-10115 Berlin, Germany; Institute of Biology, Humboldt Universität zu Berlin, D-10099 Berlin, Germany., Drewe-Boss P; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, D-10115 Berlin, Germany; Institute of Biology, Humboldt Universität zu Berlin, D-10099 Berlin, Germany., Liss M; Neuromuscular and Cardiovascular Cell Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, D-13092 Berlin, Germany; German Center for Cardiovascular Research (DZHK), Partner site Berlin, D-10117 Berlin, Germany., Katus HA; Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, D-69120 Heidelberg, Germany; German Center for Cardiovascular Research (DZHK), Partner site Heidelberg, D-69120 Heidelberg, Germany., Ohler U; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, D-10115 Berlin, Germany; Institute of Biology, Humboldt Universität zu Berlin, D-10099 Berlin, Germany., Gotthardt M; Neuromuscular and Cardiovascular Cell Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, D-13092 Berlin, Germany; German Center for Cardiovascular Research (DZHK), Partner site Berlin, D-10117 Berlin, Germany., Laufs U; Klinik und Poliklinik für Kardiologie, Universitätskrankenhaus Leipzig, D-04103 Leipzig, Germany., Streckfuss-Bömeke K; Department of Cardiology and Pneumology, University Hospital, Georg-August University Goettingen, D-37075 Goettingen, Germany; German Center for Cardiovascular Research (DZHK), Partner site Goettingen, D-37075 Goettingen, Germany., Meder B; Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, D-69120 Heidelberg, Germany; German Center for Cardiovascular Research (DZHK), Partner site Heidelberg, D-69120 Heidelberg, Germany; Stanford Genome Technology Center, Department of Genetics, Stanford Medical School, Palo Alto, CA 94304, USA. Electronic address: Benjamin.Meder@med.uni-heidelberg.de.

Publikováno v: Genomics, proteomics & bioinformatics [Genomics Proteomics Bioinformatics] 2022 Feb; Vol. 20 (1), pp. 129-146. Date of Electronic Publication: 2021 Jul 15.