Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Knethen, A. von"'
Autor:
Neb, Holger, Talbot, Steven Roger, Ruskowski, Katharina, Brkic, Djurdjina, Sonntagbauer, Michael, Adam, Elisabeth Hannah, Knethen, Andreas von, Zacharowski, Kai D., Heinicke, Ulrike
Publikováno v:
Shock. 58:514-523
Background: Severe progression of coronavirus disease 2019 (COVID-19) causes respiratory failure and critical illness. Recently, COVID-19 has been associated with heparanase (HPSE)-induced endothelial barrier dysfunction and inflammation, so called e
Acute respiratory distress syndrome (ARDS) is a major cause of patient mortality in intensive care units (ICUs) worldwide. Considering that no causative treatment but only symptomatic care is available, it is obvious that there is a high unmet medica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______610::c27b42c8890c22bf86c1931e5fe1a65b
https://publica.fraunhofer.de/handle/publica/416196
https://publica.fraunhofer.de/handle/publica/416196
Autor:
Gunne, Sandra, Heinicke, Ulrike, Parnham, Michael J., Laux, Volker, Zacharowski, Kai, Knethen, Andreas von
The transcription factor NF-E2 p45-related factor 2 (Nrf2) is an established master regulator of the anti-oxidative and detoxifying cellular response. Thus, a role in inflammatory diseases associated with the generation of large amounts of reactive o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______603::efc6588f85485479c9b2587125b76786
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/57224
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/57224
Autor:
Mertens, C., Kuchler, L., Sola, A., Guiteras, R., Grein, S., Brüne, B., Knethen, A. von, Jung, M.
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 20
Dipòsit Digital de la UB
Universidad de Barcelona
International Journal of Molecular Sciences, Vol 21, Iss 7527, p 7527 (2020)
Volume 21
Issue 20
Dipòsit Digital de la UB
Universidad de Barcelona
International Journal of Molecular Sciences, Vol 21, Iss 7527, p 7527 (2020)
During the course of sepsis in critically ill patients, kidney dysfunction and damage are among the first events of a complex scenario toward multi-organ failure and patient death. Acute kidney injury triggers the release of lipocalin-2 (Lcn-2), whic
Autor:
Elzahhar, P.A., Alaaeddine, R., Ibrahim, T.M., Nassra, R., Ismail, A., Chua, B.S.K., Frkic, R.L., Bruning, J.B., Wallner, N., Knape, T., Knethen, A. von, Labib, H., El-Yazbi, A.F., Belal, A.S.F.
In search for effective multi-targeting drug ligands (MTDLs) to address low-grade inflammatory changes of metabolic disorders, we rationally designed some novel glitazones-like compounds. This was achieved by incorporating prominent pharmacophoric mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______610::dedd3967deb5139b194887be548b0701
https://publica.fraunhofer.de/handle/publica/258098
https://publica.fraunhofer.de/handle/publica/258098
Autor:
Knethen, A. von, Brüne, B.
Sepsis is characterized by dysregulated gene expression, provoking a hyper-inflammatory response occurring in parallel to a hypo-inflammatory reaction. This is often associated with multi-organ failure, leading to the patient's death. Therefore, repr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______610::00311355e3a8f8c4acd8a4dfbf7ce1de
https://publica.fraunhofer.de/handle/publica/258380
https://publica.fraunhofer.de/handle/publica/258380
Autor:
Knethen, A. von, Schäfer, A., Kuchler, L., Knape, T., Christen, U., Hintermann, E., Fisslthaler, B., Schröder, K., Brandes, R.P., Genz, B., Abshagen, K., Pützer, B.M., Sha, L.K., Weigert, A., Syed, S.N., Schulz, M., Shah, A.M., Ernst, A., Putyrski, M., Finkelmeier, F., Pesic, M., Greten, F., Hoghardt, M., Kempf, V.A.J., Gunne, S., Parnham, M.J., Brüne, B.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______610::f7016274ee761ef910a907b31264c10a
https://publica.fraunhofer.de/handle/publica/260284
https://publica.fraunhofer.de/handle/publica/260284
Autor:
Hernandez-Olmos, V., Knape, T., Heering, J., Knethen, A. von, Kilu, W., Kaiser, A., Wurglics, M., Helmstadter, M., Merk, D., Schubert-Zsilavecz, M., Parnham, M.J., Steinhilber, D., Proschak, E.
Peroxisome proliferator-activated receptor gamma (PPARg) modulators have found wide application for the treatment of cancers, metabolic disorders and inflammatory diseases. Contrary to PPARg agonists, PPARg antagonists have been much less studied and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______610::d684ecc4317e7e24739858f6f6b1274a
https://publica.fraunhofer.de/handle/publica/260202
https://publica.fraunhofer.de/handle/publica/260202
Autor:
Knape, T., Wilken-Schmitz, A., Schneider, A.K., Arne, O., Schmidt, M., Götze, L., Hofmann, M.C.J., Bruin, N.M.W.J. de, Gerdes, C., Glenschek-Sieberth, M., Schmidt, M.V., Remie, R., Brill, B., Parnham, M.J., Knethen, A. von
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______610::5492e532e28fdab92c485fc57843410f
https://publica.fraunhofer.de/handle/publica/260282
https://publica.fraunhofer.de/handle/publica/260282