The effect of gem-difluorination on the conformation and properties of a model macrocyclic system.

Autor: Cogswell, T. J., Lewis, R. J., Sköld, C., Nordqvist, A., Ahlqvist, M., Knerr, L.

Publikováno v: Chemical Science; 12/21/2024, Vol. 15 Issue 47, p19770-19776, 7p

Incorporation of Intracellular NanoSIMS Tracers to Oligonucleotide Conjugates via Strain Promoted Sydnone-Alkyne Cycloaddition.

Autor: Lincy-Bianchi L; Medicinal Chemistry, Research and Development, Early Cardiovascular, Renal and Metabolism, Biopharmaceuticals R&D, AstraZeneca, SE-431 83 Gothenburg, Sweden., Häfner M; Medicinal Chemistry, Research and Development, Early Cardiovascular, Renal and Metabolism, Biopharmaceuticals R&D, AstraZeneca, SE-431 83 Gothenburg, Sweden., Becquart C; DMPK, Early Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, SE-431 83 Gothenburg, Sweden., Tängemo C; Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, SE-431 83 Gothenburg, Sweden., Kurczy ME; DMPK, Early Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, SE-431 83 Gothenburg, Sweden., Munier CC; Medicinal Chemistry, Research and Development, Early Cardiovascular, Renal and Metabolism, Biopharmaceuticals R&D, AstraZeneca, SE-431 83 Gothenburg, Sweden., Knerr L; Medicinal Chemistry, Research and Development, Early Cardiovascular, Renal and Metabolism, Biopharmaceuticals R&D, AstraZeneca, SE-431 83 Gothenburg, Sweden.

Publikováno v: Bioconjugate chemistry [Bioconjug Chem] 2024 Jul 17; Vol. 35 (7), pp. 912-921. Date of Electronic Publication: 2024 Jun 11.

A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype.

Autor: Haniff HS; The Scripps Research Institute, Department of Chemistry, 130 Scripps Way, Jupiter, FL 33458, USA., Liu X; The Scripps Research Institute, Department of Chemistry, 130 Scripps Way, Jupiter, FL 33458, USA., Tong Y; The Scripps Research Institute, Department of Chemistry, 130 Scripps Way, Jupiter, FL 33458, USA., Meyer SM; The Scripps Research Institute, Department of Chemistry, 130 Scripps Way, Jupiter, FL 33458, USA., Knerr L; Medicinal Chemistry, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden, 1, Gothenburg, Mölndal 431 83, Sweden., Lemurell M; Medicinal Chemistry, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden, 1, Gothenburg, Mölndal 431 83, Sweden., Abegg D; The Scripps Research Institute, Department of Chemistry, 130 Scripps Way, Jupiter, FL 33458, USA., Aikawa H; The Scripps Research Institute, Department of Chemistry, 130 Scripps Way, Jupiter, FL 33458, USA., Adibekian A; The Scripps Research Institute, Department of Chemistry, 130 Scripps Way, Jupiter, FL 33458, USA., Disney MD; The Scripps Research Institute, Department of Chemistry, 130 Scripps Way, Jupiter, FL 33458, USA. Electronic address: disney@scripps.edu.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2022 Feb 17; Vol. 29 (2), pp. 300-311.e10. Date of Electronic Publication: 2021 Jul 27.

Melanocortin 1 Receptor Agonists Based on a Bivalent, Bicyclic Peptide Framework.

Autor: Durek T; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, QLD 4072, Australia., Kaas Q; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, QLD 4072, Australia., White AM; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, QLD 4072, Australia., Weidmann J; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, QLD 4072, Australia., Fuaad AA; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, QLD 4072, Australia., Cheneval O; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, QLD 4072, Australia., Schroeder CI; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, QLD 4072, Australia., de Veer SJ; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, QLD 4072, Australia., Dellsén A; Mechanistic Biology & Profiling, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg 43183, Mölndal, Sweden., Österlund T; Discovery Biology, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg 43183, Mölndal, Sweden.; Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca, Gothenburg 43183, Mölndal, Sweden., Larsson N; Discovery Biology, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg 43183, Mölndal, Sweden., Knerr L; Medicinal Chemistry, Cardiovascular and Metabolic Diseases, IMED Biotech Unit, AstraZeneca, Gothenburg 43183, Mölndal, Sweden., Bauer U; Medicinal Chemistry, Cardiovascular and Metabolic Diseases, IMED Biotech Unit, AstraZeneca, Gothenburg 43183, Mölndal, Sweden., Plowright AT; Medicinal Chemistry, Cardiovascular and Metabolic Diseases, IMED Biotech Unit, AstraZeneca, Gothenburg 43183, Mölndal, Sweden., Craik DJ; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, QLD 4072, Australia.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Jul 22; Vol. 64 (14), pp. 9906-9915. Date of Electronic Publication: 2021 Jul 01.

Attachment of ρ-aminobenzene sulphonic acid into magnetic Fe3O4 reduced graphene oxide and its application for sensitive determination of L-tryptophan in milk and banana samples.

Autor: Admasu, Tarekegn Getinet^1,2, Halefom, Tesfu Hailu^1,3 tesfu.hailu@aastu.edu.et, Debebe, Siraye Esubalew^1,3

Publikováno v: International Journal of Electrochemical Science. Nov2024, Vol. 19 Issue 11, p1-11. 11p.