An Additional Lrp4 High Bone Mass Mutation Mitigates the Sost-Knockout Phenotype in Mice by Increasing Bone Remodeling.

Autor: Hendrickx G; Centre for Medical Genetics, University and University Hospital of Antwerp, Antwerp, Belgium.; Department of Human Genetics, KU Leuven, Louvain, Belgium., Boudin E; Centre for Medical Genetics, University and University Hospital of Antwerp, Antwerp, Belgium., Mateiu L; Centre for Medical Genetics, University and University Hospital of Antwerp, Antwerp, Belgium., Yorgan TA; Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Steenackers E; Centre for Medical Genetics, University and University Hospital of Antwerp, Antwerp, Belgium., Kneissel M; Diseases of Aging and Regenerative Medicine, Novartis Institutes for BioMedical Research, Basel, Switzerland., Kramer I; Diseases of Aging and Regenerative Medicine, Novartis Institutes for BioMedical Research, Basel, Switzerland., Mortier G; Centre for Medical Genetics, University and University Hospital of Antwerp, Antwerp, Belgium.; Department of Human Genetics, KU Leuven, Louvain, Belgium., Schinke T; Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Van Hul W; Centre for Medical Genetics, University and University Hospital of Antwerp, Antwerp, Belgium. wim.vanhul@uantwerpen.be.

Publikováno v: Calcified tissue international [Calcif Tissue Int] 2024 Feb; Vol. 114 (2), pp. 171-181. Date of Electronic Publication: 2023 Dec 05.

Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5.

Autor: Diegel CR; Department of Cell Biology, Van Andel Institute, 333 Bostwick Ave., NE, Grand Rapids, MI, 49503, USA., Kramer I; Diseases of Aging and Regenerative Medicine, Novartis Institutes for Biomedical Research, CH-4002, Basel, Switzerland., Moes C; Diseases of Aging and Regenerative Medicine, Novartis Institutes for Biomedical Research, CH-4002, Basel, Switzerland., Foxa GE; Department of Cell Biology, Van Andel Institute, 333 Bostwick Ave., NE, Grand Rapids, MI, 49503, USA., McDonald MJ; Department of Cell Biology, Van Andel Institute, 333 Bostwick Ave., NE, Grand Rapids, MI, 49503, USA., Madaj ZB; Bioinformatics and Biostatistics Core, Van Andel Institute, 333 Bostwick Ave., NE, Grand Rapids, MI, 49503, USA., Guth S; Diseases of Aging and Regenerative Medicine, Novartis Institutes for Biomedical Research, CH-4002, Basel, Switzerland., Liu J; Oncology, Novartis Institutes for Biomedical Research, San Diego, CA, 92121, USA., Harris JL; Oncology, Novartis Institutes for Biomedical Research, San Diego, CA, 92121, USA., Kneissel M; Diseases of Aging and Regenerative Medicine, Novartis Institutes for Biomedical Research, CH-4002, Basel, Switzerland., Williams BO; Department of Cell Biology, Van Andel Institute, 333 Bostwick Ave., NE, Grand Rapids, MI, 49503, USA. bart.williams@vai.org.

Publikováno v: Bone research [Bone Res] 2023 Aug 24; Vol. 11 (1), pp. 47. Date of Electronic Publication: 2023 Aug 24.

Angiopoietin-like 3-derivative LNA043 for cartilage regeneration in osteoarthritis: a randomized phase 1 trial.

Autor: Gerwin N; Novartis Institutes for BioMedical Research, Basel, Switzerland. nicole.gerwin@novartis.com., Scotti C; Novartis Pharma, Basel, Switzerland., Halleux C; Novartis Institutes for BioMedical Research, Basel, Switzerland., Fornaro M; Novartis Institutes for BioMedical Research, Basel, Switzerland., Elliott J; Novartis Institutes for BioMedical Research, San Diego, CA, USA., Zhang Y; Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Johnson K; Division of Scripps Research, Calibr, La Jolla, CA, USA., Shi J; Novartis Institutes for BioMedical Research, San Diego, CA, USA., Walter S; Novartis Institutes for BioMedical Research, Basel, Switzerland., Li Y; Novartis Institutes for BioMedical Research, Basel, Switzerland., Jacobi C; Novartis Institutes for BioMedical Research, Basel, Switzerland., Laplanche N; Novartis Institutes for BioMedical Research, Basel, Switzerland., Belaud M; Novartis Institutes for BioMedical Research, Basel, Switzerland., Paul J; Praxisklinik Rennbahn, Muttenz, Switzerland., Glowacki G; Novartis Pharma, Basel, Switzerland., Peters T; Novartis Institutes for BioMedical Research, Basel, Switzerland., Wharton KA Jr; Ultivue, Cambridge, MA, USA., Vostiar I; Novartis Institutes for BioMedical Research, Basel, Switzerland., Polus F; Novartis Institutes for BioMedical Research, Basel, Switzerland., Kramer I; Novartis Institutes for BioMedical Research, Basel, Switzerland., Guth S; Novartis Institutes for BioMedical Research, Basel, Switzerland., Seroutou A; Novartis Pharma, Basel, Switzerland., Choudhury S; IQVIA, Thane, India., Laurent D; Novartis Institutes for BioMedical Research, Basel, Switzerland., Gimbel J; Arizona Research Center, Phoenix, AZ, USA., Goldhahn J; Institute for Translational Medicine, ETH Zürich, Zürich, Switzerland., Schieker M; Novartis Institutes for BioMedical Research, Basel, Switzerland., Brachat S; Novartis Institutes for BioMedical Research, Basel, Switzerland., Roubenoff R; Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Kneissel M; Novartis Institutes for BioMedical Research, Basel, Switzerland.

Publikováno v: Nature medicine [Nat Med] 2022 Dec; Vol. 28 (12), pp. 2633-2645. Date of Electronic Publication: 2022 Dec 01.

LNA043 A NOVEL CANDIDATE FOR OSTEOARTHRITIS TREATMENT INDUCES CARTILAGE REGENERATION AND REVERSES THE OSTEOARTHRITIS TRANSCRIPTOME

Autor: Gerwin, N., Halleux, C., Fornaro, M., Elliott, J., Zhang, Y., Walter, S., Glowacki, G., Johnson, K., Shi, J., Peters, T., Laurent, D., Goldhahn, J., Schieker, M., Scotti, C., Brachat, S.L., Roubenoff, R., Kneissel, M.

Publikováno v: In Osteoarthritis and Cartilage April 2022 30 Supplement 1:S71-S71

Influence of a low calcium and phosphorus diet on the anabolic effect of human parathyroid hormone (1-38) in female rats

Autor: Steiner, P.D, Forrer, R, Kneissel, M, Gasser, J.A, Thomsen, J.S, Mosekilde, Li, Riond, J.-L ^*

Publikováno v: In Bone 2001 29(4):344-351