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To continue or not to continue? Antipsychotic medication maintenance versus dose-reduction/discontinuation in first episode psychosis: HAMLETT, a pragmatic multicenter single-blind randomized controlled trial.

Autor: Begemann MJH; Department of Biomedical Sciences of Cells & Systems, Cognitive Neurosciences, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands. m.j.h.begemann@umcg.nl., Thompson IA; Department of Biomedical Sciences of Cells & Systems, Cognitive Neurosciences, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands., Veling W; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Gangadin SS; Department of Biomedical Sciences of Cells & Systems, Cognitive Neurosciences, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands.; Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands., Geraets CNW; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., van 't Hag E; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Müller-Kuperus SJ; Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands., Oomen PP; Department of Biomedical Sciences of Cells & Systems, Cognitive Neurosciences, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands., Voppel AE; Department of Biomedical Sciences of Cells & Systems, Cognitive Neurosciences, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands., van der Gaag M; Parnassia Psychiatric Institute, The Hague, The Netherlands.; Department of Clinical Psychology, VU University, Amsterdam, The Netherlands., Kikkert MJ; Department of Research, Arkin Mental Health Care, Amsterdam, The Netherlands., Van Os J; Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, EURON, Maastricht University Medical Center, Maastricht, The Netherlands.; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK., Smit HFE; Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands.; Department of Clinical, Neuro and Developmental Psychology, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands.; Centre of Economic Evaluation, Trimbos Institute (Netherlands Institute of Mental Health), Utrecht, The Netherlands., Knegtering RH; Lentis Research, Lentis Psychiatric Institute, Groningen, The Netherlands.; Rob Giel Research Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Wiersma S; Early Intervention Psychosis Team, GGZ inGeest Specialized Mental Health Care, Hoofddorp, The Netherlands., Stouten LH; Centre for Early Psychosis, Parnassia Psychiatric Institute, The Hague, The Netherlands., Gijsman HJ; Program for Psychosis & Severe Mental Illness, Pro Persona Mental Health, Wolfheze, The Netherlands., Wunderink L; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Education and Research, Friesland Mental Health Care Services, Leeuwarden, The Netherlands., Staring ABP; Department ABC, Altrecht Psychiatric Institute, Utrecht, The Netherlands., Veerman SRT; Community Mental Health, Mental Health Service Noord-Holland Noord, Alkmaar, The Netherlands., Mahabir AGS; Early Psychosis Team, GGNet, Apeldoorn, The Netherlands., Kurkamp J; Center for Youth with Psychosis, Mediant ABC Twente, Enschede, The Netherlands., Pijnenborg GHM; Department of Psychotic Disorders, GGZ-Drenthe, Assen, The Netherlands., Veen ND; GGZ Delfland, Delfland Institute for Mental Health Care, Delft, The Netherlands., Marcelis M; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, EURON, Maastricht University Medical Center, Maastricht, The Netherlands.; Institute for Mental Health Care Eindhoven (GGzE), Eindhoven, The Netherlands., Grootens KP; Reinier van Arkel Institute for Mental Health Care, 's Hertogenbosch, The Netherlands.; Radboud University Medical Centre, Nijmegen, The Netherlands., Faber G; Yulius, Mental Health Institute, Dordrecht, The Netherlands., van Beveren NJ; Antes Center for Mental Health Care, Rotterdam, The Netherlands.; Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands.; Department of Psychiatry, Erasmus MC, Rotterdam, The Netherlands., Been A; Center for Developmental Disorders, Dimence Institute for Mental Health, Deventer, The Netherlands., van den Brink T; Early Intervention Team, GGZ Centraal, Amersfoort, The Netherlands., Bak M; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, EURON, Maastricht University Medical Center, Maastricht, The Netherlands.; Mondriaan Mental Health Care, Heerlen, The Netherlands., van Amelsvoort TAMJ; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, EURON, Maastricht University Medical Center, Maastricht, The Netherlands.; Mondriaan Mental Health Care, Heerlen, The Netherlands., Ruissen A; Emergis, Kenniscentrum, Goes, The Netherlands., Blanke C; Anoiksis, University Medical Center Utrecht, Utrecht, The Netherlands., Groen K; MIND Ypsilon, Organization of Relatives and Carers of People with a Vulnerability to Psychosis, The Hague, The Netherlands., de Haan L; Department of Early Psychosis, Amsterdam UMC, Academic Medical Center, Amsterdam, The Netherlands., Sommer IEC; Department of Biomedical Sciences of Cells & Systems, Cognitive Neurosciences, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands.

Publikováno v: Trials [Trials] 2020 Feb 07; Vol. 21 (1), pp. 147. Date of Electronic Publication: 2020 Feb 07.