Phosphorylation barcodes direct biased chemokine signaling at CXCR3.

Autor: Eiger DS; Department of Biochemistry, Duke University, Durham, NC 27710, USA., Smith JS; Department of Dermatology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Dermatology, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Dermatology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA; Dermatology Program, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA., Shi T; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Stepniewski TM; Research Program on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM), Department of Experimental and Health Sciences of Pompeu Fabra University (UPF), 08003 Barcelona, Spain., Tsai CF; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Honeycutt C; Trinity College, Duke University, Durham, NC 27710, USA., Boldizsar N; Trinity College, Duke University, Durham, NC 27710, USA., Gardner J; Trinity College, Duke University, Durham, NC 27710, USA., Nicora CD; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Moghieb AM; R&D Research, GlaxoSmithKline, Collegeville, PA 19426, USA., Kawakami K; Department of Pharmaceutical Sciences, Tohoku University, Sendai 980-8577, Japan., Choi I; Department of Medicine, Duke University, Durham, NC 27710, USA., Hicks C; Trinity College, Duke University, Durham, NC 27710, USA., Zheng K; Harvard Medical School, Boston, MA 02115, USA., Warman A; Trinity College, Duke University, Durham, NC 27710, USA., Alagesan P; Department of Biochemistry, Duke University, Durham, NC 27710, USA., Knape NM; Department of Biochemistry, Duke University, Durham, NC 27710, USA., Huang O; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA., Silverman JD; College of Information Sciences and Technology, The Pennsylvania State University, University Park, PA 16802, USA., Smith RD; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Inoue A; Department of Pharmaceutical Sciences, Tohoku University, Sendai 980-8577, Japan., Selent J; Research Program on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM), Department of Experimental and Health Sciences of Pompeu Fabra University (UPF), 08003 Barcelona, Spain., Jacobs JM; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Rajagopal S; Department of Biochemistry, Duke University, Durham, NC 27710, USA; Department of Pharmaceutical Sciences, Tohoku University, Sendai 980-8577, Japan. Electronic address: sudarshan.rajagopal@duke.edu.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2023 Apr 20; Vol. 30 (4), pp. 362-382.e8. Date of Electronic Publication: 2023 Apr 07.

Post-irradiation intratumoral heterogeneity modulates response to immune checkpoint inhibition therapy in a murine melanoma model.

Autor: Wang J; Department of Radiation Oncology University of North Carolina-Chapel Hill, Chapel Hill, NC; Department of Radiation Oncology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning China, 110032; Department of Radiation Oncology, Dalian Municipal Central Hospital, Dalian, Liaoning China, 116033. Electronic address: wangjiezxyy@icloud.com., Sud S; Department of Radiation Oncology University of North Carolina-Chapel Hill, Chapel Hill, NC. Electronic address: shivani.sud@unchealth.unc.edu., Qu Y; Department of Thoracic Radiation Oncology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, China,110042. Electronic address: quyanli@cancerhosp-ln-cmu.com., Li L; Department of Radiation Oncology University of North Carolina-Chapel Hill, Chapel Hill, NC; Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China. Electronic address: liliantao@xzhmu.edu.cn., Zhang J; Department of Radiation Oncology University of North Carolina-Chapel Hill, Chapel Hill, NC; Department of Pancreatic Surgery, Huashan Hospital, Fudan University, Shanghai, China, 200040. Electronic address: 16111220055@fudan.edu.cn., Marron D; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC. Electronic address: dmarron@cs.unc.edu., Knape NM; Department of Radiation Oncology University of North Carolina-Chapel Hill, Chapel Hill, NC. Electronic address: Nicole_Knape@med.unc.edu., Kim IJ; Department of Radiation Oncology University of North Carolina-Chapel Hill, Chapel Hill, NC. Electronic address: isaiah_kim@med.unc.edu., Wagner KT; Department of Radiation Oncology University of North Carolina-Chapel Hill, Chapel Hill, NC. Electronic address: kyle.t.wagner@outlook.com., Zhang T; Division of Medical Oncology, Department of Medicine, Duke Cancer Institute, Duke University, Durham, NC; Department of Medicine, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX. Electronic address: tian.zhang@utsouthwestern.edu., Zhao Y; Department of Radiation Oncology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning China, 110032. Electronic address: zhaoyx2019@hotmail.com., Guo G; Department of Radiation Oncology University of North Carolina-Chapel Hill, Chapel Hill, NC; Department of Radiation Oncology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning China, 110032. Electronic address: gyguo@cmu.edu.cn., Wang AZ; Department of Radiation Oncology University of North Carolina-Chapel Hill, Chapel Hill, NC; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX. Electronic address: andrew.wang2@utsouthwestern.edu.

Publikováno v: Neoplasia (New York, N.Y.) [Neoplasia] 2023 Feb; Vol. 36, pp. 100864. Date of Electronic Publication: 2022 Dec 24.

3D printed drug-loaded implantable devices for intraoperative treatment of cancer.

Autor: Hagan CT 4th; Laboratory of Nano- and Translational Medicine, Lineberger Comprehensive Cancer Center, Carolina Center for Cancer Nanotechnology Excellence, Carolina Institute of Nanomedicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill/North Carolina State University, Chapel Hill, NC 27599, USA., Bloomquist C; Laboratory of Nano- and Translational Medicine, Lineberger Comprehensive Cancer Center, Carolina Center for Cancer Nanotechnology Excellence, Carolina Institute of Nanomedicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Warner S; Laboratory of Nano- and Translational Medicine, Lineberger Comprehensive Cancer Center, Carolina Center for Cancer Nanotechnology Excellence, Carolina Institute of Nanomedicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Knape NM; Laboratory of Nano- and Translational Medicine, Lineberger Comprehensive Cancer Center, Carolina Center for Cancer Nanotechnology Excellence, Carolina Institute of Nanomedicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Kim I; Laboratory of Nano- and Translational Medicine, Lineberger Comprehensive Cancer Center, Carolina Center for Cancer Nanotechnology Excellence, Carolina Institute of Nanomedicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Foley H; Laboratory of Nano- and Translational Medicine, Lineberger Comprehensive Cancer Center, Carolina Center for Cancer Nanotechnology Excellence, Carolina Institute of Nanomedicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Wagner KT; Laboratory of Nano- and Translational Medicine, Lineberger Comprehensive Cancer Center, Carolina Center for Cancer Nanotechnology Excellence, Carolina Institute of Nanomedicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Mecham S; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., DeSimone J; Laboratory of Nano- and Translational Medicine, Lineberger Comprehensive Cancer Center, Carolina Center for Cancer Nanotechnology Excellence, Carolina Institute of Nanomedicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA; Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Chemical Engineering, Stanford University School of Engineering, Stanford, CA 94305, USA; Carbon, Inc, Redwood City, CA 94063, USA. Electronic address: jmdesimone@stanford.edu., Wang AZ; Laboratory of Nano- and Translational Medicine, Lineberger Comprehensive Cancer Center, Carolina Center for Cancer Nanotechnology Excellence, Carolina Institute of Nanomedicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: andrew.wang2@utsouthwestern.edu.

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2022 Apr; Vol. 344, pp. 147-156. Date of Electronic Publication: 2022 Feb 22.

Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation.

Autor: Smith JS; Department of Biochemistry, Duke University, Durham, NC 27710, USA.; Department of Medicine, Duke University, Durham, NC 27710, USA., Nicholson LT; Department of Medicine, Duke University, Durham, NC 27710, USA., Suwanpradid J; Department of Dermatology, Duke University, Durham, NC 27710, USA., Glenn RA; Department of Biochemistry, Duke University, Durham, NC 27710, USA., Knape NM; Department of Biochemistry, Duke University, Durham, NC 27710, USA., Alagesan P; Department of Biochemistry, Duke University, Durham, NC 27710, USA., Gundry JN; Department of Biochemistry, Duke University, Durham, NC 27710, USA., Wehrman TS; Primity Bio, Fremont, CA 94538, USA., Atwater AR; Department of Dermatology, Duke University, Durham, NC 27710, USA., Gunn MD; Department of Medicine, Duke University, Durham, NC 27710, USA.; Department of Immunology, Duke University, Durham, NC 27710, USA., MacLeod AS; Department of Dermatology, Duke University, Durham, NC 27710, USA.; Department of Immunology, Duke University, Durham, NC 27710, USA., Rajagopal S; Department of Biochemistry, Duke University, Durham, NC 27710, USA. sudarshan.rajagopal@dm.duke.edu.; Department of Medicine, Duke University, Durham, NC 27710, USA.

Publikováno v: Science signaling [Sci Signal] 2018 Nov 06; Vol. 11 (555). Date of Electronic Publication: 2018 Nov 06.