Bedaquiline and clofazimine resistance in Mycobacterium tuberculosis: an in-vitro and in-silico data analysis

Autor: Sonnenkalb, Lindsay, Carter, Joshua James, Spitaleri, Andrea, Iqbal, Zamin, Hunt, Martin, Malone, Kerri Marie, Utpatel, Christian, Cirillo, Daniela Maria, Rodrigues, Camilla, Nilgiriwala, Kayzad Soli, Fowler, Philip William, Merker, Matthias, Niemann, Stefan, Consortium, The Comprehensive Resistance Prediction for Tuberculosis: an International, Barilar, I, Battaglia, S, Borroni, E, Brandao, AP, Brankin, A, Cabibbe, AM, Carter, J, Claxton, P, Clifton, DA, Cohen, T, Coronel, J, Crook, DW, Dreyer, V, Earle, SG, Escuyer, V, Ferrazoli, L, Fowler, PW, Gao, G Fu, Gardy, J, Gharbia, S, Ghisi, KT, Ghodousi, A, Cruz, AL Gibertoni, Grandjean, L, Grazian, C, Groenheit, R, Guthrie, JL, He, W, Hoffmann, H, Hoosdally, SJ, Ismail, NA, Jarrett, L, Joseph, L, Jou, R, Kambli, P, Khot, R, Knaggs, J, Koch, A, Kohlerschmidt, D, Kouchaki, S, Lachapelle, AS, Lalvani, A, Lapierre, S Grandjean, Laurenson, IF, Letcher, B, Lin, WH, Liu, C, Liu, D, Malone, KM, Mandal, A, Mansjö, M, Matias, D, Meintjes, G, de Freitas Mendes, F, Mihalic, M, Millard, J, Miotto, P, Mistry, N, Moore, D, Musser, KA, Ngcamu, D, Hoang, NN, Nimmo, C, Okozi, N, Oliveira, RS, Omar, SV, Paton, N, Peto, TE, Pinhata, JM Watanabe, Plesnik, S, Puyen, ZM, Rabodoarivelo, MS, Rakotosamimanana, N, Rancoita, PM, Rathod, P, Rodger, G, Rodwell, TC, Roohi, E, Santos-Lazaro, D, Shah, S, Kohl, TA, Smith, G, Solano, W, Supply, P, Surve, U, Tahseen, S, Thuong, NTT

Background: Bedaquiline is a core drug for the treatment of multidrug-resistant tuberculosis; however, the understanding of resistance mechanisms is poor, which is hampering rapid molecular diagnostics. Some bedaquiline-resistant mutants are also cro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3dc1aaf8f396193628850666e402b6

Genome-wide association studies of global Mycobacterium tuberculosis resistance to 13 antimicrobials in 10,228 genomes identify new resistance mechanisms

Autor: Earle, SG, Wilson, DJ, Barilar, I, Battaglia, S, Cirillo, DM, Clifton, DA, Crook, DW, Fowler, PW, Grazian, C, Hunt, M, Iqbal, Z, Ismail, NA, Knaggs, J, Lachapelle, AS, Merker, M, Mistry, N, Moore, D, Niemann, S, Peto, TEA, Rodrigues, C, Thwaites, G, Walker, AS

Publikováno v: PLoS Biology
PLoS Biology, 2022, 20 (8), pp.e3001755. ⟨10.1371/journal.pbio.3001755⟩

The emergence of drug-resistant tuberculosis is a major global public health concern that threatens the ability to control the disease. Whole-genome sequencing as a tool to rapidly diagnose resistant infections can transform patient treatment and cli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2785463af106f91bdf52ccc27b6610ec
https://pubmed.ncbi.nlm.nih.gov/35944070

Catalogue of mutations in Mycobacterium tuberculosis complex and their association with drug resistance

Autor: Rodwell, T, Miotto, P, Köser, C, Walker, T, Fowler, PW, Knaggs, J, Iqbal, Z, Hunt, M, Chindelevitch, L, Farhat, M, Cirillo, D, Crook, D, Comas, I, Posey, J, Vally Omar, S, Peto, T, Walker, A, Suresh, A, Uplekar, S, Laurent, S, Colman, R

Of the 10 million people estimated to have fallen ill with tuberculosis (TB) in 2019, nearly half million developed TB resistant to rifampicin (RIF), and over one million developed TB susceptible to RIF but resistant to isoniazid (INH). Drug resistan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::304e1dba0684ec62764c21ba9734bd8a
https://ora.ox.ac.uk/objects/uuid:1d4dc717-5071-45b1-aaa9-0b5c401dbbf1

GenomegaMap: within-species genome-widedN/dSestimation from over 10,000 genomes

Autor: Wilson, DJ, Crook, DW, Peto, TEA, Walker, AS, Hoosdally, SJ, Gibertoni Cruz, AL, Carter, J, Grazian, C, Earle, SG, Kouchaki, S, Lachapelle, A, Yang, Y, Clifton, DA, Fowler, PW, Iqbal, Z, Hunt, M, Knaggs, J, Smith, EG, Rathod, P, Jarrett, L, Matias, D, Cirillo, DM, Borroni, E, Battaglia, S, Ghodousi, A, Spitaleri, A, Cabibbe, A, Tahseen, S, Nilgiriwala, K, Shah, S, Rodrigues, C, Kambli, P, Surve, U, Khot, R, Niemann, S, Kohl, TA, Merker, M, Hoffmann, H, Todt, K, Plesnik, S, Ismail, N, Omar, SV, Joseph, L, Thwaites, G, Thuong, TNT, Ngoc, NH, Srinivasan, V, Walker, TM, Moore, D, Coronel, J, Solano, W, Gao, GF, He, G, Zhao, Y, Liu, C, Ma, A, Zhu, B, Laurenson, I, Claxton, P, Koch, A, Wilkinson, R, Lalvani, A, Posey, J, Gardy, J, Werngren, J, Paton, N, Jou, R, Wu, M-H, Lin, W-H, Ferrazoli, L, De Oliveira, RS, Arandjelovic, I, Chaiprasert, A, Comas, I, Roig, CJ, Drobniewski, FA, Farhat, MR, Gao, Q, Hee, ROT, Sintchenko, V, Supply, P, Van Soolingen, D

Publikováno v: Molecular Biology and Evolution
Molecular Biology and Evolution, 2020, 37 (8), pp.2450-2460. ⟨10.1093/molbev/msaa069⟩
Molecular Biology and Evolution, Oxford University Press (OUP), 2020, 37 (8), pp.2450-2460. ⟨10.1093/molbev/msaa069⟩
Digital.CSIC. Repositorio Institucional del CSIC
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11 págs, 4 figuras y fórmulas matemáticas. Material suplementario en: http://dx.doi.org/10.1093/molbev/msaa069
The dN/dS ratio provides evidence of adaptation or functional constraint in protein-coding genes by quantifying the relative excess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f28734013613db456521c1a9a29560
https://doi.org/10.1101/523316

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