Výsledky vyhledávání

Akademický článek

In Retrospect: Root-Cause Analysis of Structure-Activity Relationships in IRAK4 Inhibitor Zimlovisertib (PF-06650833).

Autor: Wright SW; Medicine Design, Pfizer Inc., 445 Eastern Point Rd, Groton, Connecticut 06340, United States., Farley KA; Medicine Design, Pfizer Inc., 445 Eastern Point Rd, Groton, Connecticut 06340, United States., Han S; Medicine Design, Pfizer Inc., 445 Eastern Point Rd, Groton, Connecticut 06340, United States., Knafels JD; Medicine Design, Pfizer Inc., 445 Eastern Point Rd, Groton, Connecticut 06340, United States., Lee KL; Inflammation and Immunology Research Unit, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2024 Mar 21; Vol. 15 (4), pp. 540-545. Date of Electronic Publication: 2024 Mar 21 (Print Publication: 2024).

Zobrazit plný text záznamu

Akademický článek

Structural studies identify angiotensin II receptor blocker-like compounds as branched-chain ketoacid dehydrogenase kinase inhibitors.

Autor: Liu S; Medicine Design, Pfizer Inc, Groton, Connecticut, USA. Electronic address: Shenping.liu@pfizer.com., Kormos BL; Medicine Design, Pfizer Inc, Cambridge, Massachusetts, USA., Knafels JD; Medicine Design, Pfizer Inc, Groton, Connecticut, USA., Sahasrabudhe PV; Medicine Design, Pfizer Inc, Groton, Connecticut, USA., Rosado A; Medicine Design, Pfizer Inc, Groton, Connecticut, USA., Sommese RF; Medicine Design, Pfizer Inc, Groton, Connecticut, USA., Reyes AR; Internal Medicine Research Unit, Pfizer Inc, Cambridge, Massachusetts, USA., Ward J; Internal Medicine Research Unit, Pfizer Inc, Cambridge, Massachusetts, USA., Roth Flach RJ; Internal Medicine Research Unit, Pfizer Inc, Cambridge, Massachusetts, USA., Wang X; Medicine Design, Pfizer Inc, Groton, Connecticut, USA., Buzon LM; Medicine Design, Pfizer Inc, Groton, Connecticut, USA., Reese MR; Medicine Design, Pfizer Inc, Groton, Connecticut, USA., Bhattacharya SK; Medicine Design, Pfizer Inc, Cambridge, Massachusetts, USA., Omoto K; Medicine Design, Pfizer Inc, Cambridge, Massachusetts, USA., Filipski KJ; Medicine Design, Pfizer Inc, Cambridge, Massachusetts, USA. Electronic address: Kevin.Filipski@pfizer.com.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2023 Mar; Vol. 299 (3), pp. 102959. Date of Electronic Publication: 2023 Jan 28.

Zobrazit plný text záznamu

Akademický článek

Macrocyclic Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonists.

Autor: Schnute ME; Medicine Design, Pfizer Inc., Cambridge, Massachusetts 02139, United States., Trujillo JI; Medicine Design, Pfizer Inc., Groton, Connecticut 06340, United States., Lee KL; Medicine Design, Pfizer Inc., Cambridge, Massachusetts 02139, United States., Unwalla R; Medicine Design, Pfizer Inc., Cambridge, Massachusetts 02139, United States., Vajdos FF; Medicine Design, Pfizer Inc., Groton, Connecticut 06340, United States., Kauppi B; Karo Pharma AB, 111 48 Stockholm, Sweden., Nuhant P; Medicine Design, Pfizer Inc., Groton, Connecticut 06340, United States., Flick AC; Medicine Design, Pfizer Inc., Groton, Connecticut 06340, United States., Crouse KK; Inflammation and Immunology Research, Pfizer Inc., Cambridge, Massachusetts 02139, United States., Zhao Y; Inflammation and Immunology Research, Pfizer Inc., Cambridge, Massachusetts 02139, United States., Samuel A; Drug Product Design, Pfizer Inc., San Diego, California 92121, United States., Lombardo V; Medicine Design, Pfizer Inc., Groton, Connecticut 06340, United States., Taylor AP; Medicine Design, Pfizer Inc., Groton, Connecticut 06340, United States., Brault AL; Medicine Design, Pfizer Inc., Groton, Connecticut 06340, United States., Knafels JD; Medicine Design, Pfizer Inc., Groton, Connecticut 06340, United States., Vazquez ML; Medicine Design, Pfizer Inc., Cambridge, Massachusetts 02139, United States., Berstein G; Inflammation and Immunology Research, Pfizer Inc., Cambridge, Massachusetts 02139, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Jan 18; Vol. 14 (2), pp. 191-198. Date of Electronic Publication: 2023 Jan 18 (Print Publication: 2023).

Zobrazit plný text záznamu

Akademický článek

Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1.

Autor: Casimiro-Garcia A; Medicine Design, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States., Allais C; Medicine Design, Pfizer Inc., 445 Eastern Point Rd, Groton, Connecticut 06340, United States., Brennan A; Inflammation and Immunology Research Unit, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States., Choi C; Medicine Design, Pfizer Inc., 445 Eastern Point Rd, Groton, Connecticut 06340, United States., Dower G; Inflammation and Immunology Research Unit, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States., Farley KA; Medicine Design, Pfizer Inc., 445 Eastern Point Rd, Groton, Connecticut 06340, United States., Fleming M; Inflammation and Immunology Research Unit, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States., Flick A; Medicine Design, Pfizer Inc., 445 Eastern Point Rd, Groton, Connecticut 06340, United States., Frisbie RK; Medicine Design, Pfizer Inc., 445 Eastern Point Rd, Groton, Connecticut 06340, United States., Hall J; Medicine Design, Pfizer Inc., 445 Eastern Point Rd, Groton, Connecticut 06340, United States., Hepworth D; Medicine Design, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States., Jones H; Medicine Design, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States., Knafels JD; Medicine Design, Pfizer Inc., 445 Eastern Point Rd, Groton, Connecticut 06340, United States., Kortum S; Medicine Design, Pfizer Inc., 445 Eastern Point Rd, Groton, Connecticut 06340, United States., Lovering FE; Medicine Design, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States., Mathias JP; Medicine Design, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States., Mohan S; Inflammation and Immunology Research Unit, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States., Morgan PM; Inflammation and Immunology Research Unit, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States., Parng C; Medicine Design, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States., Parris K; Medicine Design, Pfizer Inc., 445 Eastern Point Rd, Groton, Connecticut 06340, United States., Pullen N; Inflammation and Immunology Research Unit, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States., Schlerman F; Inflammation and Immunology Research Unit, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States., Stansfield J; Early Clinical Development Non-Clinical Statistics, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States., Strohbach JW; Medicine Design, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States., Vajdos FF; Medicine Design, Pfizer Inc., 445 Eastern Point Rd, Groton, Connecticut 06340, United States., Vincent F; Medicine Design, Pfizer Inc., 445 Eastern Point Rd, Groton, Connecticut 06340, United States., Wang H; Medicine Design, Pfizer Inc., 445 Eastern Point Rd, Groton, Connecticut 06340, United States., Wang X; Medicine Design, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States., Webster R; Medicine Design, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States., Wright SW; Medicine Design, Pfizer Inc., 445 Eastern Point Rd, Groton, Connecticut 06340, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 Jan 13; Vol. 65 (1), pp. 757-784. Date of Electronic Publication: 2021 Dec 30.

Zobrazit plný text záznamu

Akademický článek

Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases.

Autor: Gerstenberger BS; Pfizer Inc., Cambridge, Massachusetts 02139, United States., Ambler C; Pfizer Inc., Groton, Connecticut 06340, United States., Arnold EP; Pfizer Inc., Groton, Connecticut 06340, United States., Banker ME; Pfizer Inc., Groton, Connecticut 06340, United States., Brown MF; Pfizer Inc., Groton, Connecticut 06340, United States., Clark JD; Pfizer Inc., Cambridge, Massachusetts 02139, United States., Dermenci A; Pfizer Inc., Groton, Connecticut 06340, United States., Dowty ME; Pfizer Inc., Cambridge, Massachusetts 02139, United States., Fensome A; Pfizer Inc., Cambridge, Massachusetts 02139, United States., Fish S; Pfizer Inc., Cambridge, Massachusetts 02139, United States., Hayward MM; Pfizer Inc., Groton, Connecticut 06340, United States., Hegen M; Pfizer Inc., Cambridge, Massachusetts 02139, United States., Hollingshead BD; Pfizer Inc., Cambridge, Massachusetts 02139, United States., Knafels JD; Pfizer Inc., Groton, Connecticut 06340, United States., Lin DW; Pfizer Inc., Groton, Connecticut 06340, United States., Lin TH; Pfizer Inc., Cambridge, Massachusetts 02139, United States., Owen DR; Pfizer Inc., Cambridge, Massachusetts 02139, United States., Saiah E; Pfizer Inc., Cambridge, Massachusetts 02139, United States., Sharma R; Pfizer Inc., Groton, Connecticut 06340, United States., Vajdos FF; Pfizer Inc., Groton, Connecticut 06340, United States., Xing L; Pfizer Inc., Cambridge, Massachusetts 02139, United States., Yang X; Pfizer Inc., Groton, Connecticut 06340, United States., Yang X; Pfizer Inc., Groton, Connecticut 06340, United States., Wright SW; Pfizer Inc., Groton, Connecticut 06340, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 Nov 25; Vol. 63 (22), pp. 13561-13577. Date of Electronic Publication: 2020 Aug 25.

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání