Functional impairment of systemic scleroderma patients with digital ulcerations: results from the DUO Registry

Autor: Guillevin, L, Hunsche, E, Denton, Cp, Krieg, T, Schwierin, B, Rosenberg, D, Matucci-Cerinic, M, Raffier, B, Hirschi, M, Trautinger, F, Schmidt, P, Stetter, M, Hundstorfer, M, Reinhart, V, Monshi, B, Pirkhammer, D, Richter, L, Hamberger, N, Metz, S, Feldmann, R, Semmelweis, K, Lackner, K, Tomi, N, Kolle, H, Hafner, F, Brodmann, M, Kuen-Spiegel, M, Minmair, G, Heil, Pm, Broil, H, Holzer, G, Illmer, X, Rintelen, B, Sautner, J, Takacs, M, Thun, M, Zemanova, I, Soukup, T, Smrzova, A, Bohmova, J, Prochazkova, L, Nemec, P, Fojtik, Z, Suchy, D, Becvar, R, Olsen, Ab, Sondergaard, Kh, Luosu jarvi, R, Vidqvist, Kl, Madaule, S, Beneton, N, Maillard, H, Charlanne, H, Granelbrocard, F, Hachulla, E, Hatron, Py, Jourdain, N, Lambert, M, Launay, D, Morell, S, Woijtasik, G, Skowron, F, Zenone, T, Dadban, A, Lok, C, Ferrandiz, D, Magybertrand, N, Moiton, Mp, Taieb, A, Balquiere, S, Belin, E, Droitcourt, C, Julien, S, Prey, S, Boulon, C, Constans, J, Doutre, Ms, Kostrzwewa, E, Richez, C, Greco, M, Misery, L, Sassolas, B, Collet, E, Berthier, S, Leguy-Seguin, V, Imbert, B, Carpentier, P, Blaise, S, Couraud, A, Doeffel-Hantz, V, Spars, A, Bezanahary, H, Boussely, N, Dumonteil, S, Fauchais, Al, Goudran, G, Loustaud-Ratti, V, Manea, P, Vidal, E, Coppere, B, Desmursclavel, H, Girard-Madoux, Mh, Hot, A, Ninet, J, Granel, B, Cohen, Jd, Keynote, A, Khau van Kien, A, Le Quellec, A, Riviere, S, Rullier, P, Bessis, D, Farcas, C, Bravetti, V, Moline, T, Wahl, D, Zuily, S, Granel-Brocard, F, Agard, C, Durant, C, Fuzibet, Jg, Queyrel, V, Berezne, A, Mouthon, L, Cabane, J, Tiev, K, Toledano, C, Lazareth, I, Michon-Pasturel, U, Priollet, P, Reguiai, Z, Cazaletslacoste, C, Jego, P, Letremy, A, Perlat, A, Duval-Modeste, Ab, Chatelus, E, Chiffot, H, Sibillia, J, Sordet, C, Adoue, D, Couret, B, Moulis, G, Pugnet, G, Sailler, L, Diot, E, Gaches, F, Farge, D, Keshtmand, H, Frances, C, von Elling, A, Bora, D, Ebel, J, Ahmadi-Simab, K, Klein, E, Hahn, K, Schulze, K, Rasche, C, Riemekasten, G, Lee, Hh, Deuschle, K, Mattat, K, Becker, M, Worm, M, Mensing, C, Klings, D, Mensing, H, Messall, J, Zuper, R, Eilbacher, P, Saar, P, Kaufmann, P, Hallermann, C, Schmidt, K, Wahn, H, Schildt, K, Schuart, T, Kaczmarczyk, A, Kellner, C, von Oelhafen, J, Baron von Bildering, P, Kunze, S, Kleiner, Hj, Alsheimer, B, Schuetz, N, Miirker-Hermann, E, Gottl, Kh, Weiss, E, Reischel, N, Kern, S, Goettl, Kh, Goetheuniversitiitsklinikum, Jw, Himsel, A, Henkemeier, U, Schwarting, A, Hazenbiller, A, Nichelmann, V, Rumbaur, C, Boesenberg, I, Schmeiser, T, Mueller-Ladner, U, Unholzer, A, Starz, H, Welzel, J, Plaumann, K, Stoeckl, F, Sperling, S, Podda, M, Wagner, N, Rapprich, H, Niedermeier, A, Messer, G, Sardy, M, Bekou, V, Dill-MUller, D, Wlodarz, M, Belloni, B, Huettig, B, Ziai, M, Hein, R, Kneitz, C, Federow, I, Schneider, K, Semmler, M, Hapke, S, Metzler, C, Stein, T, Enderlein, M, Kayser, M, Werthmann, M, Guenther, Cu, Neul, S, Hellmich, B, Loeffler, C, Pflugfelder, J, Karaenke, P, Mueglich, C, Tony, Hp, 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Publikováno v: Europe PubMed Central
Web of Science
ResearcherID

Digital ulcers (DUs) are frequent manifestations of systemic scleroderma (SSc). This study assessed functional limitations due to DUs among patients enrolled in the Digital Ulcer Outcome (DUO) Registry, an international, multicentre, observational re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::36b38d094db92bf9ef75895b4f85d02e
http://europepmc.org/abstract/med/23910613

Neutrophil Extracellular Traps Drive Endothelial-to-Mesenchymal Transition.

Autor: Pieterse E; From the Nephrology Research Laboratory, Department of Nephrology (E.P., N.R., M.G., J.M.H., M.A.L., J.H.M.B., L.B.H., J.v.d.V.), Department of Rheumatology (H.K.K.), and Department of Obstetrics & Gynecology (O.W.H.v.d.H.), Radboud University Medical Center, Nijmegen, The Netherlands; Academic Renal Unit, School of Clinical Science, University of Bristol, United Kingdom (S.C.S.); and Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich Alexander University of Erlangen-Nuremberg, Germany (M.H.)., Rother N; From the Nephrology Research Laboratory, Department of Nephrology (E.P., N.R., M.G., J.M.H., M.A.L., J.H.M.B., L.B.H., J.v.d.V.), Department of Rheumatology (H.K.K.), and Department of Obstetrics & Gynecology (O.W.H.v.d.H.), Radboud University Medical Center, Nijmegen, The Netherlands; Academic Renal Unit, School of Clinical Science, University of Bristol, United Kingdom (S.C.S.); and Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich Alexander University of Erlangen-Nuremberg, Germany (M.H.)., Garsen M; From the Nephrology Research Laboratory, Department of Nephrology (E.P., N.R., M.G., J.M.H., M.A.L., J.H.M.B., L.B.H., J.v.d.V.), Department of Rheumatology (H.K.K.), and Department of Obstetrics & Gynecology (O.W.H.v.d.H.), Radboud University Medical Center, Nijmegen, The Netherlands; Academic Renal Unit, School of Clinical Science, University of Bristol, United Kingdom (S.C.S.); and Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich Alexander University of Erlangen-Nuremberg, Germany (M.H.)., Hofstra JM; From the Nephrology Research Laboratory, Department of Nephrology (E.P., N.R., M.G., J.M.H., M.A.L., J.H.M.B., L.B.H., J.v.d.V.), Department of Rheumatology (H.K.K.), and Department of Obstetrics & Gynecology (O.W.H.v.d.H.), Radboud University Medical Center, Nijmegen, The Netherlands; Academic Renal Unit, School of Clinical Science, University of Bristol, United Kingdom (S.C.S.); and Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich Alexander University of Erlangen-Nuremberg, Germany (M.H.)., Satchell SC; From the Nephrology Research Laboratory, Department of Nephrology (E.P., N.R., M.G., J.M.H., M.A.L., J.H.M.B., L.B.H., J.v.d.V.), Department of Rheumatology (H.K.K.), and Department of Obstetrics & Gynecology (O.W.H.v.d.H.), Radboud University Medical Center, Nijmegen, The Netherlands; Academic Renal Unit, School of Clinical Science, University of Bristol, United Kingdom (S.C.S.); and Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich Alexander University of Erlangen-Nuremberg, Germany (M.H.)., Hoffmann M; From the Nephrology Research Laboratory, Department of Nephrology (E.P., N.R., M.G., J.M.H., M.A.L., J.H.M.B., L.B.H., J.v.d.V.), Department of Rheumatology (H.K.K.), and Department of Obstetrics & Gynecology (O.W.H.v.d.H.), Radboud University Medical Center, Nijmegen, The Netherlands; Academic Renal Unit, School of Clinical Science, University of Bristol, United Kingdom (S.C.S.); and Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich Alexander University of Erlangen-Nuremberg, Germany (M.H.)., Loeven MA; From the Nephrology Research Laboratory, Department of Nephrology (E.P., N.R., M.G., J.M.H., M.A.L., J.H.M.B., L.B.H., J.v.d.V.), Department of Rheumatology (H.K.K.), and Department of Obstetrics & Gynecology (O.W.H.v.d.H.), Radboud University Medical Center, Nijmegen, The Netherlands; Academic Renal Unit, School of Clinical Science, University of Bristol, United Kingdom (S.C.S.); and Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich Alexander University of Erlangen-Nuremberg, Germany (M.H.)., Knaapen HK; From the Nephrology Research Laboratory, Department of Nephrology (E.P., N.R., M.G., J.M.H., M.A.L., J.H.M.B., L.B.H., J.v.d.V.), Department of Rheumatology (H.K.K.), and Department of Obstetrics & Gynecology (O.W.H.v.d.H.), Radboud University Medical Center, Nijmegen, The Netherlands; Academic Renal Unit, School of Clinical Science, University of Bristol, United Kingdom (S.C.S.); and Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich Alexander University of Erlangen-Nuremberg, Germany (M.H.)., van der Heijden OWH; From the Nephrology Research Laboratory, Department of Nephrology (E.P., N.R., M.G., J.M.H., M.A.L., J.H.M.B., L.B.H., J.v.d.V.), Department of Rheumatology (H.K.K.), and Department of Obstetrics & Gynecology (O.W.H.v.d.H.), Radboud University Medical Center, Nijmegen, The Netherlands; Academic Renal Unit, School of Clinical Science, University of Bristol, United Kingdom (S.C.S.); and Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich Alexander University of Erlangen-Nuremberg, Germany (M.H.)., Berden JHM; From the Nephrology Research Laboratory, Department of Nephrology (E.P., N.R., M.G., J.M.H., M.A.L., J.H.M.B., L.B.H., J.v.d.V.), Department of Rheumatology (H.K.K.), and Department of Obstetrics & Gynecology (O.W.H.v.d.H.), Radboud University Medical Center, Nijmegen, The Netherlands; Academic Renal Unit, School of Clinical Science, University of Bristol, United Kingdom (S.C.S.); and Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich Alexander University of Erlangen-Nuremberg, Germany (M.H.)., Hilbrands LB; From the Nephrology Research Laboratory, Department of Nephrology (E.P., N.R., M.G., J.M.H., M.A.L., J.H.M.B., L.B.H., J.v.d.V.), Department of Rheumatology (H.K.K.), and Department of Obstetrics & Gynecology (O.W.H.v.d.H.), Radboud University Medical Center, Nijmegen, The Netherlands; Academic Renal Unit, School of Clinical Science, University of Bristol, United Kingdom (S.C.S.); and Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich Alexander University of Erlangen-Nuremberg, Germany (M.H.)., van der Vlag J; From the Nephrology Research Laboratory, Department of Nephrology (E.P., N.R., M.G., J.M.H., M.A.L., J.H.M.B., L.B.H., J.v.d.V.), Department of Rheumatology (H.K.K.), and Department of Obstetrics & Gynecology (O.W.H.v.d.H.), Radboud University Medical Center, Nijmegen, The Netherlands; Academic Renal Unit, School of Clinical Science, University of Bristol, United Kingdom (S.C.S.); and Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich Alexander University of Erlangen-Nuremberg, Germany (M.H.). johan.vandervlag@radboudumc.nl.

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Use of Mycophenolate Mofetil in Patients with Severe Localized Scleroderma Resistant or Intolerant to Methotrexate.

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