The retinoid X receptor has a critical role in synthetic rexinoid-induced increase in cellular all-trans-retinoic acid.

Autor: Belyaeva OV; Department of Biochemistry and Molecular Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States of America., Klyuyeva AV; Department of Biochemistry and Molecular Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States of America., Vyas A; Department of Biochemistry and Molecular Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States of America., Berger WK; Departments of Medicine and Biological Chemistry, Johns Hopkins University School of Medicine, Institute for Fundamental Biomedical Research, Johns Hopkins All Children's Hospital, St. Petersburg, FL, United States of America., Halasz L; Departments of Medicine and Biological Chemistry, Johns Hopkins University School of Medicine, Institute for Fundamental Biomedical Research, Johns Hopkins All Children's Hospital, St. Petersburg, FL, United States of America., Yu J; Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, United States of America., Atigadda VR; Department of Dermatology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States of America., Slay A; Department of Biochemistry and Molecular Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States of America., Goggans KR; Department of Biochemistry and Molecular Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States of America., Renfrow MB; Department of Biochemistry and Molecular Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States of America., Kane MA; Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, United States of America., Nagy L; Departments of Medicine and Biological Chemistry, Johns Hopkins University School of Medicine, Institute for Fundamental Biomedical Research, Johns Hopkins All Children's Hospital, St. Petersburg, FL, United States of America., Kedishvili NY; Department of Biochemistry and Molecular Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States of America.

Publikováno v: PloS one [PLoS One] 2024 Apr 01; Vol. 19 (4), pp. e0301447. Date of Electronic Publication: 2024 Apr 01 (Print Publication: 2024).

A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells.

Autor: Li J; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, 36604, USA.; Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, 36604, USA., Garavaglia S; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Largo Donegani 2, 28100, Novara, Italy., Ye Z; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA.; School of Medicine, Tsinghua University, Beijing, China., Moretti A; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Largo Donegani 2, 28100, Novara, Italy.; Structural Plant Biology Laboratory, Department of Botany and Plant Biology, University of Geneva, 1211, Geneva, Switzerland., Belyaeva OV; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Schools of Medicine and Dentistry, 720 20th Street South, Kaul 440B, Birmingham, AL, 35294, USA., Beiser A; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, 36604, USA.; Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, 36604, USA., Ibrahim M; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, 36604, USA.; Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, 36604, USA., Wilk A; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, 36604, USA.; Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, 36604, USA., McClellan S; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, 36604, USA., Klyuyeva AV; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Schools of Medicine and Dentistry, 720 20th Street South, Kaul 440B, Birmingham, AL, 35294, USA., Goggans KR; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Schools of Medicine and Dentistry, 720 20th Street South, Kaul 440B, Birmingham, AL, 35294, USA., Kedishvili NY; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Schools of Medicine and Dentistry, 720 20th Street South, Kaul 440B, Birmingham, AL, 35294, USA., Salter EA; Department of Chemistry, University of South Alabama, 6040 USA South Drive, Mobile, AL, 36688, USA., Wierzbicki A; Department of Chemistry, University of South Alabama, 6040 USA South Drive, Mobile, AL, 36688, USA., Migaud ME; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, 36604, USA.; Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, 36604, USA., Mullett SJ; Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Yates NA; Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Camacho CJ; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Rizzi M; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Largo Donegani 2, 28100, Novara, Italy. menico.rizzi@uniupo.it., Sobol RW; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, 36604, USA. rwsobol@southalabama.edu.; Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, 36604, USA. rwsobol@southalabama.edu.

Publikováno v: Communications biology [Commun Biol] 2021 Dec 21; Vol. 4 (1), pp. 1420. Date of Electronic Publication: 2021 Dec 21.

Application of human organotypic skin raft cultures for analysis of retinoid metabolism, retinoic acid signaling, and screening of bioactive rexinoids.

Autor: Klyuyeva AV; Department of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama at Birmingham, Birmingham, AL, United States., Goggans KR; Department of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama at Birmingham, Birmingham, AL, United States., Kedishvili NY; Department of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama at Birmingham, Birmingham, AL, United States., Belyaeva OV; Department of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama at Birmingham, Birmingham, AL, United States. Electronic address: obeliaeva@uab.edu.

Publikováno v: Methods in enzymology [Methods Enzymol] 2020; Vol. 637, pp. 493-512. Date of Electronic Publication: 2020 Mar 28.