Inhibition of thioredoxin-dependent H2O2 removal sensitizes malignant B-cells to pharmacological ascorbate

Autor: Graczyk-Jarzynka, Agnieszka, Goral, Agnieszka, Muchowicz, Angelika, Zagozdzon, Radoslaw, Winiarska, Magdalena, Bajor, Malgorzata, Trzeciecka, Anna, Fidyt, Klaudyna, Krupka, Joanna Alicja, Cyran, Julia, Szczygiel, Kacper, Efremov, Dimitar G., Gobessi, Stefania, Jagielski, Adam, Siudakowska, Karolina, Bobrowicz, Malgorzata, Klopotowska, Marta, Barankiewicz, Joanna, Malenda, Agata, Lech-Maranda, Ewa, Miazek-Zapala, Nina, Skarzynski, Piotr Henryk, Domagala, Antoni, Golab, Jakub, Firczuk, Malgorzata

Publikováno v: In Redox Biology February 2019 21

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PD-L1 CAR effector cells induce self-amplifying cytotoxic effects against target cells.

Autor: Bajor M; Department of Clinical Immunology, Medical University of Warsaw, Warszawa, Mazowieckie, Poland.; Laboratory of Immunology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland., Graczyk-Jarzynka A; Laboratory of Immunology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland.; Department of Immunology, Medical University of Warsaw, Warszawa, Poland., Marhelava K; Department of Clinical Immunology, Medical University of Warsaw, Warszawa, Mazowieckie, Poland.; Postgraduate School of Molecular Medicine, Medical University of Warsaw, Warsaw, Poland.; Laboratory for Cellular and Genetic Therapies, Medical University of Warsaw, Warsaw, Poland., Burdzinska A; Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Warszawa, Poland., Muchowicz A; Department of Immunology, Medical University of Warsaw, Warszawa, Poland., Goral A; Department of Immunology, Medical University of Warsaw, Warszawa, Poland., Zhylko A; Department of Immunology, Medical University of Warsaw, Warszawa, Poland.; Doctoral School, Medical University of Warsaw, Warsaw, Poland., Soroczynska K; Department of Immunology, Medical University of Warsaw, Warszawa, Poland., Retecki K; Department of Immunology, Medical University of Warsaw, Warszawa, Poland., Krawczyk M; Laboratory of Immunology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland.; Department of Immunology, Medical University of Warsaw, Warszawa, Poland.; Laboratory for Cellular and Genetic Therapies, Medical University of Warsaw, Warsaw, Poland.; Doctoral School of Translational Medicine, Centre of Postgraduate Medical Education, Warsaw, Poland., Klopotowska M; Department of Clinical Immunology, Medical University of Warsaw, Warszawa, Mazowieckie, Poland.; Laboratory of Immunology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland., Pilch Z; Department of Immunology, Medical University of Warsaw, Warszawa, Poland., Paczek L; Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Warszawa, Poland.; Department of Bioinformatics, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland., Malmberg KJ; Department of Cancer Immunology, Radiumhospitalet, Oslo, Norway., Wälchli S; Department of Cellular Therapy, Oslo University Hospital, Oslo, Norway., Winiarska M; Department of Immunology, Medical University of Warsaw, Warszawa, Poland mwiniarska@wum.edu.pl radoslaw.zagozdzon@wum.edu.pl., Zagozdzon R; Department of Clinical Immunology, Medical University of Warsaw, Warszawa, Mazowieckie, Poland mwiniarska@wum.edu.pl radoslaw.zagozdzon@wum.edu.pl.; Laboratory for Cellular and Genetic Therapies, Medical University of Warsaw, Warsaw, Poland.; Department of Bioinformatics, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.; Department of Regenerative Medicine, The Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2022 Jan; Vol. 10 (1).