Zobrazeno 1 - 10
of 312
pro vyhledávání: '"Klinghofer"'
Autor:
Yan Shi, Xuesong Liu, Edward K. Han, Ran Guan, Alexander R. Shoemaker, Anatol Oleksijew, Keith W. Woods, John P. Fisher, Vered Klinghofer, Loren Lasko, Thomas McGonigal, Qun Li, Saul H. Rosenberg, Vincent L. Giranda, Yan Luo
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 7, Iss 11, Pp 992-1000 (2005)
Akt is a serine/threonine kinase that transduces survival signals from survival/growth factors. Deregulation and signal imbalance in cancer cells make them prone to apoptosis. Upregulation or activation of Akt to aid the survival of cancer cells is a
Externí odkaz:
https://doaj.org/article/9ba95b7759d4450b84e42eb7e6f9afad
Autor:
Kleinert, Hollis D., Rosenberg, Saul H., Baker, William R., Stein, Herman H., Klinghofer, Vered, Barlow, Jennifer, Spina, Kenneth, Polakowski, James, Kovar, Peter, Cohen, Jerome, Denissen, Jon
Publikováno v:
Science, 1992 Sep . 257(5078), 1940-1943.
Externí odkaz:
https://www.jstor.org/stable/2879800
Autor:
Penning, Thomas D., Zhu, Gui-Dong, Gandhi, Viraj B., Gong, Jianchun, Thomas, Sheela, Lubisch, Wilfried, Grandel, Roland, Wernet, Wolfgang, Park, Chang H., Fry, Elizabeth H., Liu, Xuesong, Shi, Yan, Klinghofer, Vered, Johnson, Eric F., Donawho, Cherrie K., Frost, David J., Bontcheva-Diaz, Velitchka, Bouska, Jennifer J., Olson, Amanda M., Marsh, Kennan C., Luo, Yan, Rosenberg, Saul H., Giranda, Vincent L.
Publikováno v:
In Bioorganic & Medicinal Chemistry 2008 16(14):6965-6975
Autor:
Zhu, Gui-Dong, Gong, Jianchun, Gandhi, Viraj B., Woods, Keith, Luo, Yan, Liu, Xuesong, Guan, Ran, Klinghofer, Vered, Johnson, Eric F., Stoll, Vincent S., Mamo, Mulugeta, Li, Qun, Rosenberg, Saul H., Giranda, Vincent L.
Publikováno v:
In Bioorganic & Medicinal Chemistry 2007 15(6):2441-2452
Autor:
Woods, Keith W., Fischer, John P., Claiborne, Akiyo, Li, Tongmei, Thomas, Sheela A., Zhu, Gui-Dong, Diebold, Robert B., Liu, Xuesong, Shi, Yan, Klinghofer, Vered, Han, Edward K., Guan, Ran, Magnone, Shayna R., Johnson, Eric F., Bouska, Jennifer J., Olson, Amanda M., Jong, Ron de, Oltersdorf, Tilman, Luo, Yan, Rosenberg, Saul H., Giranda, Vincent L., Li, Qun
Publikováno v:
In Bioorganic & Medicinal Chemistry 2006 14(20):6832-6846
Autor:
Shi, Yan, Liu, Xuesong, Han, Edward K., Guan, Ran, Shoemaker, Alexander R., Oleksijew, Anatol, Woods, Keith W., Fisher, John P., Klinghofer, Vered, Lasko, Loren, McGonigal, Thomas, Li, Qun, Rosenberg, Saul H., Giranda, Vincent L., Luo, Yan
Publikováno v:
In Neoplasia November 2005 7(11):992-1000
Autor:
Nienaber, Vicki L *, Davidson, Donald, Edalji, Rohinton, Giranda, Vincent L, Klinghofer, Vered, Henkin, Jack, Magdalinos, Peter, Mantei, Robert, Merrick, Sean, Severin, Jean M, Smith, Richard A, Stewart, Kent, Walter, Karl, Wang, Jieyi, Wendt, Michael, Weitzberg, Moshe, Zhao, Xumiao, Rockway, Todd *
Publikováno v:
In Structure 2000 8(5):553-563
Autor:
Kent D. Stewart, Stevan W. Djuric, Anil Vasudevan, Jennifer J. Bouska, Zhiren Xia, Vincent L. Giranda, Thomas D. Penning, Eric F. Johnson, Loren M. Lasko, Alexander R. Shoemaker, Qingwei Zhang, Michael J. Mitten, Yan Luo, Vered Klinghofer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7615-7622
A high throughput screening (HTS) hit, 1 (Plk1 Ki = 2.2 μM) was optimized and evaluated for the enzymatic inhibition of Plk-1 kinase. Molecular modeling suggested the importance of adding a hydrophobic aromatic amine side chain in order to improve t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb65d4435bdfe8b18f3f9b0255678660
https://doi.org/10.1016/j.bmcl.2012.10.009
https://doi.org/10.1016/j.bmcl.2012.10.009
Autor:
Gui-Dong Zhu, Xuesong Liu, Yan Shi, Thomas D. Penning, Viraj B. Gandhi, Chang Park, Vered Klinghofer, Vincent L. Giranda, Yan Luo, Eric F. Johnson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1023-1026
Through conformational restriction of a benzamide by formation of a seven-membered hydrogen-bond with an oxindole carbonyl group, a series of PARP inhibitors was designed for appropriate orientation for binding to the PARP surface. This series of com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::929701d4d80100ea0c052b63fadaa574
https://doi.org/10.1016/j.bmcl.2009.12.042
https://doi.org/10.1016/j.bmcl.2009.12.042
Autor:
Roswitha Klinghofer, Peter Schwind, Lydia Markut, Esther Rainer, Elfriede Pircher, Günther F. Körmöczi, Diether Schönitzer, Christoph Gassner, Christof Jungbauer, Harald Schennach, Dietmar Wessin
Publikováno v:
Transfusion Medicine and Hemotherapy. 36:219-225
Background: Validations of routinely used serological typing methods require intense performance evaluations typically including large numbers of samples before routine application. However, such evaluations could be improved considering information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27cded98f528d3051f5f8adb16a65181
https://doi.org/10.1159/000215935
https://doi.org/10.1159/000215935