The ribotoxin α-sarcin can cleave the sarcin/ricin loop on late 60S pre-ribosomes

Autor: Olombrada, Miriam, Peña, Cohue, Rodríguez-Galán, Olga, Klingauf-Nerurkar, Purnima, Portugal-Calisto, Daniela, Oborská-Oplová, Michaela, Altvater, Martin, Gavilanes, José G, Martínez-del-Pozo, Álvaro, de la Cruz, Jesús, García-Ortega, Lucía, Panse, Vikram Govind

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
E-Prints Complutense. Archivo Institucional de la UCM
E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
Nucleic Acids Research
Nucleic Acids Research, 48 (11)

The ribotoxin α-sarcin belongs to a family of ribonucleases that cleave the sarcin/ricin loop (SRL), a critical functional rRNA element within the large ribosomal subunit (60S), thereby abolishing translation. Whether α-sarcin targets the SRL only

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::97f26ebc2009ae6b5367bbce6d8b2d58
https://doi.org/10.5167/uzh-190530

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The GTPase Nog1 co-ordinates the assembly, maturation and quality control of distant ribosomal functional centers

Autor: Klingauf-Nerurkar, Purnima, Gillet, Ludovic C, Portugal-Calisto, Daniela, Oborská-Oplová, Michaela, Jäger, Martin, Schubert, Olga T, Pisano, Agnese, Peña, Cohue, Rao, Sanjana, Altvater, Martin, Chang, Yiming, Aebersold, Ruedi, Panse, Vikram G

Publikováno v: eLife
eLife, 9
eLife, Vol 9 (2020)

Eukaryotic ribosome precursors acquire translation competence in the cytoplasm through stepwise release of bound assembly factors, and proofreading of their functional centers. In case of the pre-60S, these steps include removal of placeholders Rlp24

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2cd9ff68c7ae365e422f5035528bb62
https://pubmed.ncbi.nlm.nih.gov/31909713

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