Majority of hMLH1 mutations responsible for hereditary nonpolyposis colorectal cancer cluster at the exonic region 15-16

Autor: Wijnen, J., Meera Khan, P., Vasen, H., Menko, F., Klift, H. D., Broek, M. D., Leeuwen-Cornelisse, I., Nagengast, F., Meijers-Heijboer, E. J., Dick Lindhout, Griffioen, G., Cats, A., Kleibeuker, J., Varesco, L., Bertario, L., Bisgaard, M. -L, Mohr, J., Kolodner, R., Fodde, R.

Publikováno v: American journal of human genetics, 58(2), 300-307. Cell Press
Scopus-Elsevier
American Journal of Human Genetics, 58(2), 300-307. CELL PRESS

Hereditary nonpolyposis colorectal cancer (HNPCC) is a common autosomal dominant cancer susceptibility condition. Inherited mutations in at least four DNA mismatch repair genes, hMSH2, hMLH1, hPMS1, and hPMS2, are known to cause HNPCC. In this study

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https://pure.amc.nl/en/publications/majority-of-hmlh1-mutations-responsible-for-hereditary-nonpolyposis-colorectal-cancer-cluster-at-the-exonic-region-1516(bd8d5666-73d7-4dc6-b945-d2a20246e272).html