A fitness assay for comparing RNAi effects across multiple C. elegans genotypes

Autor: Kammenga Jan E, Klemstein Ulrike, Frejno Martin, Snoek Laurens B, Elvin Mark, Poulin Gino B

Publikováno v: BMC Genomics, Vol 12, Iss 1, p 510 (2011)

Abstract Background RNAi technology by feeding of E. coli containing dsRNA in C. elegans has significantly contributed to further our understanding of many different fields, including genetics, molecular biology, developmental biology and functional

Externí odkaz: https://doaj.org/article/6937ef5fb5d140a69d24883318d128bd

RadH: A Versatile Halogenase for Integration into Synthetic Pathways

Autor: Menon, Binuraj R. K., Brandenburger, Eileen, Sharif, Humera H., Klemstein, Ulrike, Shepherd, Sarah A., Greaney, Michael F., Micklefield, Jason

Publikováno v: Angewandte Chemie (International Ed. in English)

Flavin‐dependent halogenases are useful enzymes for providing halogenated molecules with improved biological activity, or intermediates for synthetic derivatization. We demonstrate how the fungal halogenase RadH can be used to regioselectively halo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d8ccc98736b92ce6e941f3309df601
https://doi.org/10.1002/ange.201706342

Structure and biocatalytic scope of thermophilic flavin-dependent halogenase and flavin reductase enzymes

Autor: Menon, Binuraj, Latham, Jonathan, Dunstan, Mark, Brandenburger, Eileen, Klemstein, Ulrike, Leys, David, Karthikeyan, Chinnan V., Greaney, Michael, Shepherd, Sarah, Micklefield, Jason

Publikováno v: Menon, B, Latham, J, Dunstan, M, Brandenburger, E, Klemstein, U, Leys, D, Karthikeyan, C V, Greaney, M, Shepherd, S & Micklefield, J 2016, ' Structure and biocatalytic scope of thermophilic flavin-dependent halogenase and flavin reductase enzymes ', Organic and Biomolecular Chemistry, vol. 14, pp. 9354-9361 . https://doi.org/10.1039/C6OB01861K

Flavin-dependent halogenase (Fl-Hal) enzymes have been shown to halogenate a range of synthetic as well as natural aromatic compounds. The exquisite regioselectively of Fl-Hal enzymes can provide halogenated building blocks which are inaccessible usi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3818::488ba73b5b85c91706b8480e91ea020d
https://doi.org/10.1039/C6OB01861K

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