DNA methylation patterns reflect individual's lifestyle independent of obesity

Autor: Klemp, Ireen

Objective: Obesity is driven by modifiable lifestyle factors whose effects may be mediated by epigenetics. Therefore, we investigated lifestyle effects on blood DNA methylation in participants of the LIFE-Adult study, a well-characterised population-

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DNA methylation patterns reflect individual's lifestyle independent of obesity.

Autor: Klemp I; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Hoffmann A; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Zentrum München, University of Leipzig and University Hospital Leipzig, Leipzig, Germany., Müller L; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Hagemann T; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Zentrum München, University of Leipzig and University Hospital Leipzig, Leipzig, Germany., Horn K; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany., Rohde-Zimmermann K; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Zentrum München, University of Leipzig and University Hospital Leipzig, Leipzig, Germany., Tönjes A; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Thiery J; Medical Faculty, University of Kiel, Kiel, Germany., Löffler M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany., Burkhardt R; Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany., Böttcher Y; Department of Clinical Molecular Biology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Medical Division, Akershus University Hospital, Lørenskog, Norway., Stumvoll M; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Zentrum München, University of Leipzig and University Hospital Leipzig, Leipzig, Germany.; Deutsches Zentrum für Diabetesforschung, Neuherberg, Germany., Blüher M; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Zentrum München, University of Leipzig and University Hospital Leipzig, Leipzig, Germany., Krohn K; Medical Faculty, University of Leipzig, Leipzig, Germany., Scholz M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany., Baber R; Medical Faculty, University of Leipzig, Leipzig, Germany.; LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany., Franks PW; Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden., Kovacs P; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Keller M; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Zentrum München, University of Leipzig and University Hospital Leipzig, Leipzig, Germany.

Publikováno v: Clinical and translational medicine [Clin Transl Med] 2022 Jun; Vol. 12 (6), pp. e851.