The von Willebrand factor Tyr2561 allele is a gain-of-function variant and a risk factor for early myocardial infarction

Autor: Schneppenheim, Reinhard ^*, Hellermann, Natalie, Brehm, Maria A., Klemm, Ulrike, Obser, Tobias, Huck, Volker, Schneider, Stefan W., Denis, Cécile V., Tischer, Alexander, Auton, Matthew, März, Winfried, Xu, Emma-Ruoqi, Wilmanns, Matthias, Zotz, Rainer B.

Publikováno v: In Blood 24 January 2019 133(4):356-365

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The Von Willebrand Factor Tyr2561 Allele Is a Gain-of-Function Variant and a Potential Risk Factor for Early Myocardial Infarction

Autor: Schneppenheim, Reinhard, Hellermann, Natalie ^*, Brehm, Maria Alexandra ^*, Klemm, Ulrike ^*, Obser, Tobias ^*, Huck, Volker ^*, Schneider, Stefan W ^*, Denis, Cecile V., Tischer, Alexander ^*, Auton, Matthew ^*, Maerz, Winfried ^*, Xu, Emma-Ruoqi ^*, Wilmanns, Matthias ^*, Zotz, Rainer B. ^*

Publikováno v: In Blood 29 November 2018 132 Supplement 1:2459-2459

Strongyloides ratti Infection Induces Expansion of Foxp3⁺ Regulatory T Cells That Interfere with Immune Response and Parasite Clearance in BALB/c Mice.

Autor: Blankenhaus, Birte¹, Klemm, Ulrike¹, Eschbach, Marie-Luise¹, Sparwasser, Tim², Huehn, Jochen³, Kühl, Anja A.⁴, Loddenkemper, Christoph⁴, Jacobs, Thomas¹, Breloer, Minka¹ breloer@bnitm.de

Publikováno v: Journal of Immunology. 4/1/2011, Vol. 186 Issue 7, p4295-4305. 11p.

Gain-of-Function Variant p.Pro2555Arg of von Willebrand Factor Increases Aggregate Size through Altering Stem Dynamics.

Autor: Huck V; Department of Dermatology and Venereology, Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Experimental Dermatology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Chen PC; Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Xu ER; European Molecular Biology Laboratory, Hamburg Unit, Hamburg, Germany., Tischer A; Division of Hematology, Mayo Clinic, Rochester, Minnesota, United States., Klemm U; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Aponte-Santamaría C; Max Planck Tandem Group in Computational Biophysics, University of los Andes, Bogotá, Colombia.; Interdisciplinary Center for Scientific Computing, Heidelberg University, Heidelberg, Germany., Mess C; Department of Dermatology and Venereology, Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Obser T; Department of Dermatology and Venereology, Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kutzki F; Molecular Biomechanics Group, Heidelberg Institute for Theoretical Studies, Heidelberg, Germany.; Institute of Physical Chemistry, Karlsruhe Institute of Technology, Karlsruhe, Germany., König G; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Denis CV; Laboratory of Hemostasis, Inflammation and Thrombosis, Institut National de la Santé et de la Recherche Médicale UMR_1176, Université Paris-Saclay, Le Kremlin-Bicêtre, France., Gräter F; Interdisciplinary Center for Scientific Computing, Heidelberg University, Heidelberg, Germany.; Molecular Biomechanics Group, Heidelberg Institute for Theoretical Studies, Heidelberg, Germany., Wilmanns M; European Molecular Biology Laboratory, Hamburg Unit, Hamburg, Germany.; University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Auton M; Division of Hematology, Mayo Clinic, Rochester, Minnesota, United States., Schneider SW; Department of Dermatology and Venereology, Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Schneppenheim R; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hennig J; Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Brehm MA; Department of Dermatology and Venereology, Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Publikováno v: Thrombosis and haemostasis [Thromb Haemost] 2022 Feb; Vol. 122 (2), pp. 226-239. Date of Electronic Publication: 2021 Apr 14.