Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Klement Foo"'
Publikováno v:
Journal of the American Chemical Society. 143:13962-13970
An alcohol-directed, nickel-catalyzed three-component umpolung carboamination of unactivated alkenes with aryl/alkenylboronic esters and electrophilic aminating reagents is reported. This transformation is enabled by specifically tailored O-(2,6-dime
A versatile method to access differentially substituted 1,3- and 1,4-diamines via a nickel-catalyzed three-component 1,2-carboamination of alkenyl amines with aryl/alkenylboronic ester nucleophiles and N–O electrophiles is reported. The reaction pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb5bfeafd386f40f01fcefa54853a9e
https://doi.org/10.26434/chemrxiv-2021-x6h4c
https://doi.org/10.26434/chemrxiv-2021-x6h4c
Autor:
Susmitha Vuddagiri, Doris Hui Ying Tee, Sandra Sim, Alvin W. Hung, Gang Wang, Thomas H. Keller, Li Hong Tan, Zhiyuan Ke, Anders Poulsen, Nithya Baburajendran, Boping Liu, Vishal Pendharkar, Pearly Shuyi Ng, Jeffrey Hill, Jothi Anantharajan, Joma Joy, May Ann Lee, Zekui Perlyn Kwek, Kanda Sangthongpitag, Sifang Wang, Vithya Manoharan, Klement Foo, Chuhui Huang, Nur Huda Binte Ahmad
Publikováno v:
Bioorganicmedicinal chemistry. 49
AXL is a member of the TAM (TYRO3, AXL, MER) subfamily of receptor tyrosine kinases. It is upregulated in a variety of cancers and its overexpression is associated with poor disease prognosis and acquired drug resistance. Utilizing a fragment-based l
Autor:
Yee Hwa Wong, CongBao Kang, Xiaoying Koh-Stenta, Alex Matter, Wenhe Zhong, Hui Qi Ng, Klement Foo, Megan E. McBee, Ann Koay, Anders Poulsen, Julien Lescar, Jeffrey Hill, Abbas El Sahili, Qianhui Nah, Yan Li, Yok Hian Chionh, Anna Ngo, Meng Ling Choong, Peter C. Dedon
Publikováno v:
ACS Infectious Diseases. 5:326-335
Bacterial tRNA modification synthesis pathways are critical to cell survival under stress and thus represent ideal mechanism-based targets for antibiotic development. One such target is the tRNA-(N1G37) methyltransferase (TrmD), which is conserved an
Autor:
Joma Joy, David Quach, Priya Retna, Klement Foo, Boping Liu, John Liang Kuan Wee, Anders Poulsen, Guanghui Tang, Shao Q. Yao, Perlyn Zekui Kwek, Nithya Baburajendran, Wan-Qi Yang, Jothi Anantharajan, Thomas H. Keller, Rong Li, Chong-Jing Zhang, Doris Hui Ying Tee
Targeted covalent inhibitors have re-emerged as validated drugs to overcome acquired resistance in cancer treatment. Herein, by using a carbonyl boronic acid warhead, we report the structure-based design of BCR-ABL inhibitors via reversible covalent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171ce237421bc22447f3c94c78646d05
https://doi.org/10.26434/chemrxiv.13710097
https://doi.org/10.26434/chemrxiv.13710097
Autor:
Jeffrey Hill, Joma Joy, Grace Lin, Nurul Dinie, Justina Fulwood, Sin Yin Chew, Xiaoying Koh-Stenta, Sugunavathi Sepramaniam, Xin Hui Chew, Rong Li, Melgious Jin Yan Ang, May Ann Lee, Alex Matter, Weixuan Yu, Zhiyuan Ke, Anna Ngo, Hwa Hwa Chung, Susmitha Vuddagiri, Kanda Sangthongpitag, Klement Foo, Vithya Manoharan, C. S. Brian Chia, Sravanthy Manesh, Esther H. Q. Ong, Nithya Baburajendran, Chuhui Huang, Zekui Perlyn Kwek, John Liang Kuan Wee, Yun Shan Chew, Priya Retna, Thomas H. Keller, Anders Poulsen, Si Si Liew, Choon Bing Low, Vishal Pendharkar
Publikováno v:
ACS Med Chem Lett
[Image: see text] SMYD3 is a histone methyltransferase that regulates gene transcription, and its overexpression is associated with multiple human cancers. A novel class of tetrahydroacridine compounds which inhibit SMYD3 through a covalent mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a957218bb54c41c184fbdaf7cb115a0
https://europepmc.org/articles/PMC6580565/
https://europepmc.org/articles/PMC6580565/
Autor:
Aaron C. Burns, Cecil L Eprile, Michael R. Collins, Klement Foo, Shuhei Kawamura, Jason Ge, Ryan Gianatassio, Phil S. Baran
Publikováno v:
Angewandte Chemie. 126:10009-10013
A simple method to convert readily available carboxylic acids into sulfinate salts by employing an interrupted Barton decarboxylation reaction is reported. A medicinally oriented panel of ten new sulfinate reagents was created using this method, incl
Publikováno v:
Journal of the American Chemical Society
A simple method for direct C-H imidation is reported using a new perester-based self-immolating reagent and a base-metal catalyst. The succinimide products obtained can be easily deprotected in situ (if desired) to reveal the corresponding anilines d
Autor:
Chloe R. Jenner, Andrew J. P. White, James N. Scutt, Robert D. C. Pullin, Alan Armstrong, Klement Foo
Publikováno v:
Tetrahedron: Asymmetry. 25:74-86
trans-N- Unsubstituted aziridines were synthesised (up to 77% ee) via a chiral tertiary amine-promoted nucleophilic aziridination of α,β-unsaturated ketones utilising in situ generated N – N ylides (aminimines). A wide range of chiral tertiary am
Autor:
Sugunavathi Sepramaniam, Thomas H. Keller, Alex Matter, Xiaoying Koh-Stenta, May Ann Lee, Nurul Dinie, Anders Poulsen, Justina Fulwood, Weixuan Yu, Anna Ngo, Grace Lin, Sin Yin Chew, Xin Hui Chew, Joma Joy, Melgious Jin Yan Ang, Priya Retna, Kanda Sangthongpitag, Nithya Baburajendran, John Liang Kuan Wee, Klement Foo, Jeffrey Hill, Vithya Manoharan, Zekui Perlyn Kwek, Esther H. Q. Ong, Zhiyuan Ke, Rong Li, Chuhui Huang, Hwa Hwa Chung, C. S. Brian Chia, Yun Shan Chew, Susmitha Vuddagiri, Sravanthy Manesh, Vishal Pendharkar, Si Si Liew, Choon Bing Low
Publikováno v:
ACS Medicinal Chemistry Letters. 10:1240-1240