Machine Learning-Assisted Classification of Paraffin-Embedded Brain Tumors with Raman Spectroscopy.

Autor: Klamminger GG; Department of General and Special Pathology, Saarland University (USAAR), 66424 Homburg, Germany.; Department of General and Special Pathology, Saarland University Medical Center (UKS), 66424 Homburg, Germany.; National Center of Pathology (NCP), Laboratoire National de Santé (LNS), 3555 Dudelange, Luxembourg., Mombaerts L; Luxembourg Center of Neuropathology (LCNP), 3555 Dudelange, Luxembourg., Kemp F; Luxembourg Center of Neuropathology (LCNP), 3555 Dudelange, Luxembourg., Jelke F; National Center of Neurosurgery, Centre Hospitalier de Luxembourg (CHL), 1210 Luxembourg, Luxembourg.; Doctoral School in Science and Engineering (DSSE), University of Luxembourg (UL), 4362 Esch-sur-Alzette, Luxembourg., Klein K; National Center of Neurosurgery, Centre Hospitalier de Luxembourg (CHL), 1210 Luxembourg, Luxembourg.; Faculty of Medicine, Saarland University (USAAR), 66424 Homburg, Germany., Slimani R; Doctoral School in Science and Engineering (DSSE), University of Luxembourg (UL), 4362 Esch-sur-Alzette, Luxembourg.; Department of Cancer Research (DoCR), Luxembourg Institute of Health (LIH), 1210 Luxembourg, Luxembourg., Mirizzi G; National Center of Neurosurgery, Centre Hospitalier de Luxembourg (CHL), 1210 Luxembourg, Luxembourg.; Faculty of Medicine, Saarland University (USAAR), 66424 Homburg, Germany., Husch A; National Center of Neurosurgery, Centre Hospitalier de Luxembourg (CHL), 1210 Luxembourg, Luxembourg.; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg (UL), 4362 Esch-sur-Alzette, Luxembourg., Hertel F; National Center of Neurosurgery, Centre Hospitalier de Luxembourg (CHL), 1210 Luxembourg, Luxembourg.; Faculty of Medicine, Saarland University (USAAR), 66424 Homburg, Germany., Mittelbronn M; Luxembourg Center of Neuropathology (LCNP), 3555 Dudelange, Luxembourg.; Department of Cancer Research (DoCR), Luxembourg Institute of Health (LIH), 1210 Luxembourg, Luxembourg.; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg (UL), 4362 Esch-sur-Alzette, Luxembourg.; Department of Life Sciences and Medicine (DLSM), University of Luxembourg, 4365 Esch-sur-Alzette, Luxembourg.; Faculty of Science, Technology and Medicine (FSTM), University of Luxembourg, 4365 Esch-sur-Alzette, Luxembourg., Kleine Borgmann FB; National Center of Pathology (NCP), Laboratoire National de Santé (LNS), 3555 Dudelange, Luxembourg.; National Center of Neurosurgery, Centre Hospitalier de Luxembourg (CHL), 1210 Luxembourg, Luxembourg.; Department of Cancer Research (DoCR), Luxembourg Institute of Health (LIH), 1210 Luxembourg, Luxembourg.; Hôpitaux Robert Schuman, 1130 Luxembourg, Luxembourg.

Publikováno v: Brain sciences [Brain Sci] 2024 Mar 23; Vol. 14 (4). Date of Electronic Publication: 2024 Mar 23.

Computational Assessment of Spectral Heterogeneity within Fresh Glioblastoma Tissue Using Raman Spectroscopy and Machine Learning Algorithms.

Autor: Klein K; Faculty of Medicine, Saarland University (USAAR), 66424 Homburg, Germany.; National Center of Neurosurgery, Centre Hospitalier de Luxembourg (CHL), 1210 Luxembourg, Luxembourg., Klamminger GG; Department of General and Special Pathology, Saarland University (USAAR), 66424 Homburg, Germany.; Department of General and Special Pathology, Saarland University Medical Center (UKS), 66424 Homburg, Germany.; National Center of Pathology (NCP), Laboratoire National de Santé (LNS), 3555 Dudelange, Luxembourg., Mombaerts L; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg (UL), 4362 Esch-sur-Alzette, Luxembourg., Jelke F; National Center of Neurosurgery, Centre Hospitalier de Luxembourg (CHL), 1210 Luxembourg, Luxembourg.; Doctoral School in Science and Engineering (DSSE), University of Luxembourg (UL), 4362 Esch-sur-Alzette, Luxembourg., Arroteia IF; National Center of Neurosurgery, Centre Hospitalier de Luxembourg (CHL), 1210 Luxembourg, Luxembourg., Slimani R; Doctoral School in Science and Engineering (DSSE), University of Luxembourg (UL), 4362 Esch-sur-Alzette, Luxembourg.; Luxembourg Center of Neuropathology (LCNP), 3555 Dudelange, Luxembourg.; Department of Cancer Research (DoCR), Luxembourg Institute of Health (LIH), 1210 Luxembourg, Luxembourg., Mirizzi G; Faculty of Medicine, Saarland University (USAAR), 66424 Homburg, Germany.; National Center of Neurosurgery, Centre Hospitalier de Luxembourg (CHL), 1210 Luxembourg, Luxembourg., Husch A; National Center of Neurosurgery, Centre Hospitalier de Luxembourg (CHL), 1210 Luxembourg, Luxembourg.; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg (UL), 4362 Esch-sur-Alzette, Luxembourg., Frauenknecht KBM; National Center of Pathology (NCP), Laboratoire National de Santé (LNS), 3555 Dudelange, Luxembourg.; Luxembourg Center of Neuropathology (LCNP), 3555 Dudelange, Luxembourg.; Department of Cancer Research (DoCR), Luxembourg Institute of Health (LIH), 1210 Luxembourg, Luxembourg., Mittelbronn M; National Center of Pathology (NCP), Laboratoire National de Santé (LNS), 3555 Dudelange, Luxembourg.; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg (UL), 4362 Esch-sur-Alzette, Luxembourg.; Luxembourg Center of Neuropathology (LCNP), 3555 Dudelange, Luxembourg.; Department of Cancer Research (DoCR), Luxembourg Institute of Health (LIH), 1210 Luxembourg, Luxembourg.; Department of Life Sciences and Medicine (DLSM), University of Luxembourg, 4365 Esch-sur-Alzette, Luxembourg.; Faculty of Science, Technology and Medicine (FSTM), University of Luxembourg, 4365 Esch-sur-Alzette, Luxembourg., Hertel F; Faculty of Medicine, Saarland University (USAAR), 66424 Homburg, Germany.; National Center of Neurosurgery, Centre Hospitalier de Luxembourg (CHL), 1210 Luxembourg, Luxembourg., Kleine Borgmann FB; Faculty of Medicine, Saarland University (USAAR), 66424 Homburg, Germany.; National Center of Neurosurgery, Centre Hospitalier de Luxembourg (CHL), 1210 Luxembourg, Luxembourg.; Department of Cancer Research (DoCR), Luxembourg Institute of Health (LIH), 1210 Luxembourg, Luxembourg.; Hôpitaux Robert Schuman, 1130 Luxembourg, Luxembourg.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2024 Feb 23; Vol. 29 (5). Date of Electronic Publication: 2024 Feb 23.

Extracellular Vesicle Secretion by Leukemia Cells In Vivo Promotes CLL Progression by Hampering Antitumor T-cell Responses.

Autor: Gargiulo E; Tumor-Stroma Interactions Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg City, Luxembourg., Viry E; Tumor-Stroma Interactions Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg City, Luxembourg., Morande PE; Tumor-Stroma Interactions Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg City, Luxembourg.; Instituto de Medicina Experimental (IMEX)-CONICET-Academia Nacional de Medicina, Buenos Aires, Argentina., Largeot A; Tumor-Stroma Interactions Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg City, Luxembourg., Gonder S; Tumor-Stroma Interactions Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg City, Luxembourg.; Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg., Xian F; Proteomics of Cellular Signaling, Department of Infection and Immunity, Luxembourg Institute of Health, Strassen, Luxembourg., Ioannou N; School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom., Benzarti M; Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Cancer Metabolism Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg City, Luxembourg., Kleine Borgmann FB; Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Department of Neurosurgery, Centre Hospitalier de Luxembourg, Luxembourg City, Luxembourg.; Luxembourg Centre of Neuropathology, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg City, Luxembourg., Mittelbronn M; Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Luxembourg Centre of Neuropathology, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg City, Luxembourg.; Luxembourg Centre of Neuropathology, University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Department of Life Sciences and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.; National Center of Pathology, Laboratoire national de santé (LNS), Dudelange, Luxembourg.; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg., Dittmar G; Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Proteomics of Cellular Signaling, Department of Infection and Immunity, Luxembourg Institute of Health, Strassen, Luxembourg., Nazarov PV; Multiomics Data Science Group, Department of Cancer Research, Luxembourg Institute of Health, Strassen, Luxembourg., Meiser J; Cancer Metabolism Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg City, Luxembourg., Stamatopoulos B; Labora-tory of Clinical Cell Therapy, Jules Bordet Institute, Université Libre de Bruxelles, Brussels, Belgium., Ramsay AG; School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom., Moussay E; Tumor-Stroma Interactions Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg City, Luxembourg., Paggetti J; Tumor-Stroma Interactions Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg City, Luxembourg.

Publikováno v: Blood cancer discovery [Blood Cancer Discov] 2023 Jan 06; Vol. 4 (1), pp. 54-77.

From Research to Diagnostic Application of Raman Spectroscopy in Neurosciences: Past and Perspectives.

Autor: Klamminger GG; Saarland University Medical Center and Faculty of Medicine, Homburg, Germany.; National Center of Pathology (NCP), Laboratoire national de santé (LNS), Dudelange, Luxembourg.; Luxembourg Center of Neuropathology (LCNP), Dudelange, Luxembourg., Frauenknecht KBM; National Center of Pathology (NCP), Laboratoire national de santé (LNS), Dudelange, Luxembourg.; Luxembourg Center of Neuropathology (LCNP), Dudelange, Luxembourg., Mittelbronn M; National Center of Pathology (NCP), Laboratoire national de santé (LNS), Dudelange, Luxembourg.; Luxembourg Center of Neuropathology (LCNP), Dudelange, Luxembourg.; Luxembourg Centre of Systems Biomedicine (LCSB), University of Luxembourg (UL), Esch-sur-Alzette, Luxembourg.; Department of Cancer Research (DoCR), Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg.; Department of Life Sciences and Medicine (DLSM), University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Faculty of Science, Technology and Medicine (FSTM), University of Luxembourg, Esch-sur-Alzette, Luxembourg., Kleine Borgmann FB; National Center of Pathology (NCP), Laboratoire national de santé (LNS), Dudelange, Luxembourg.; Luxembourg Center of Neuropathology (LCNP), Dudelange, Luxembourg.; Saarland University Medical Center and Faculty of Medicine, Homburg, Germany.; Department of Cancer Research (DoCR), Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg.

Publikováno v: Free neuropathology [Free Neuropathol] 2022 Aug 05; Vol. 3. Date of Electronic Publication: 2022 Aug 05 (Print Publication: 2022).

Application of Raman spectroscopy for detection of histologically distinct areas in formalin-fixed paraffin-embedded glioblastoma.

Autor: Klamminger GG; Saarland University Medical Center and Faculty of Medicine, Homburg, Germany., Gérardy JJ; National Center of Pathology (NCP), Laboratoire national de santé (LNS), Dudelange, Luxembourg.; Luxembourg Center of Neuropathology (LCNP), Dudelange, Luxembourg., Jelke F; Saarland University Medical Center and Faculty of Medicine, Homburg, Germany.; National Center of Neurosurgery, Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg., Mirizzi G; Saarland University Medical Center and Faculty of Medicine, Homburg, Germany.; National Center of Neurosurgery, Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg., Slimani R; Department of Oncology (DONC), Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg.; Doctoral School in Science and Engineering (DSSE), University of Luxembourg (UL), Esch-sur-Alzette, Luxembourg., Klein K; Saarland University Medical Center and Faculty of Medicine, Homburg, Germany.; National Center of Neurosurgery, Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg., Husch A; Luxembourg Centre of Systems Biomedicine (LCSB), University of Luxembourg (UL), Esch-sur-Alzette, Luxembourg., Hertel F; Saarland University Medical Center and Faculty of Medicine, Homburg, Germany.; National Center of Neurosurgery, Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg.; Luxembourg Centre of Systems Biomedicine (LCSB), University of Luxembourg (UL), Esch-sur-Alzette, Luxembourg., Mittelbronn M; National Center of Pathology (NCP), Laboratoire national de santé (LNS), Dudelange, Luxembourg.; Luxembourg Center of Neuropathology (LCNP), Dudelange, Luxembourg.; Department of Oncology (DONC), Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg.; Luxembourg Centre of Systems Biomedicine (LCSB), University of Luxembourg (UL), Esch-sur-Alzette, Luxembourg., Kleine-Borgmann FB; Saarland University Medical Center and Faculty of Medicine, Homburg, Germany.; Luxembourg Center of Neuropathology (LCNP), Dudelange, Luxembourg.; Department of Oncology (DONC), Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg.

Publikováno v: Neuro-oncology advances [Neurooncol Adv] 2021 Jun 18; Vol. 3 (1), pp. vdab077. Date of Electronic Publication: 2021 Jun 18 (Print Publication: 2021).