Author Correction: Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons.

Autor: Riemenschneider H; German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany., Guo Q; Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany.; State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, 100871, China., Bader J; Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Am Klopferspitz 18, 82152, Martinsried, Germany., Frottin F; Department of Cellular Biochemistry, Max Planck Institute for Biochemistry, Am Klopferspitz 18, 82152, Martinsried, Germany.; Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, CEA, CNRS, 91198, Gif-sur-Yvette, France., Farny D; German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany., Kleinberger G; German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany., Haass C; German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany.; Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität, Munich, Germany.; Munich Cluster of Systems Neurology (SyNergy), Feodor-Lynen-Str. 17, 81377, Munich, Germany., Mann M; Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Am Klopferspitz 18, 82152, Martinsried, Germany., Hartl FU; Department of Cellular Biochemistry, Max Planck Institute for Biochemistry, Am Klopferspitz 18, 82152, Martinsried, Germany.; Munich Cluster of Systems Neurology (SyNergy), Feodor-Lynen-Str. 17, 81377, Munich, Germany., Baumeister W; Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany., Hipp MS; Department of Cellular Biochemistry, Max Planck Institute for Biochemistry, Am Klopferspitz 18, 82152, Martinsried, Germany.; Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.; School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany., Meissner F; Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Am Klopferspitz 18, 82152, Martinsried, Germany.; Institute of Innate Immunity, Department of Systems Immunology and Proteomics, Medical Faculty, University of Bonn, Bonn, Germany., Fernández-Busnadiego R; Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany. ruben.fernandezbusnadiego@med.uni-goettingen.de.; Institute of Neuropathology, University Medical Center Göttingen, 37099, Göttingen, Germany. ruben.fernandezbusnadiego@med.uni-goettingen.de.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, 37075, Göttingen, Germany. ruben.fernandezbusnadiego@med.uni-goettingen.de., Edbauer D; German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany. dieter.edbauer@dzne.de.; Munich Cluster of Systems Neurology (SyNergy), Feodor-Lynen-Str. 17, 81377, Munich, Germany. dieter.edbauer@dzne.de.; Graduate School of Systemic Neurosciences (GSN), Ludwig-Maximilians-University Munich, 81377, Munich, Germany. dieter.edbauer@dzne.de.

Publikováno v: EMBO reports [EMBO Rep] 2024 Jul; Vol. 25 (7), pp. 3161.

Early and longitudinal microglial activation but not fibrillar amyloid accumulation predict cognitive outcome and synaptic density in PS2APP mice

Autor: Brendel, M., Focke, C., Deussing, M., Zott, B., Blune, T., Shi, Y., Beyer, L., Kleinberger, G., Lindner, S., Gildehaus, F., Bartenstein, P., Baumann, K., Haass, C., Herms, J., Adelsberger, H., Rominger, Axel Oliver

Publikováno v: Brendel, M.; Focke, C.; Deussing, M.; Zott, B.; Blune, T.; Shi, Y.; Beyer, L.; Kleinberger, G.; Lindner, S.; Gildehaus, F.; Bartenstein, P.; Baumann, K.; Haass, C.; Herms, J.; Adelsberger, H.; Rominger, Axel Oliver (2018). Early and longitudinal microglial activation but not fibrillar amyloid accumulation predict cognitive outcome and synaptic density in PS2APP mice. European journal of nuclear medicine and molecular imaging, 45(S1), S206-S207. Springer-Verlag

Introduction: Microglial activation is one hallmark in the pathophysiology of neurodegenerative diseases. However, results are still inconclusive whether neuroinflammation has beneficial or detrimental effects on cognitive outcome. 18kDa translocator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00d8a1fc4b6b0e068aa28fffaf406deb
https://boris.unibe.ch/126197/1/Brendel_Early_and_longitudinal_microglial_activation.pdf

Signatures of glial activity can be detected in the CSF proteome.

Autor: Eninger T; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, 72076 Tübingen, Germany.; German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany., Müller SA; German Center for Neurodegenerative Diseases, 81377 Munich, Germany.; Neuroproteomics, School of Medicine, Klinikum Rechts der Isar, Technische Universität München, 80333 Munich, Germany., Bacioglu M; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, 72076 Tübingen, Germany.; German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany.; Graduate Training Centre of Neuroscience, University of Tübingen, 72076 Tübingen, Germany., Schweighauser M; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, 72076 Tübingen, Germany.; German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany., Lambert M; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, 72076 Tübingen, Germany.; German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany., Maia LF; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, 72076 Tübingen, Germany.; Neurology Department, Centro Hospitalar Universitário do Porto, 4099-001 Porto, Portugal.; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, 4200-393 Portugal., Neher JJ; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, 72076 Tübingen, Germany.; German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany., Hornfeck SM; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, 72076 Tübingen, Germany.; German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany.; Graduate Training Centre of Neuroscience, University of Tübingen, 72076 Tübingen, Germany., Obermüller U; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, 72076 Tübingen, Germany.; German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany., Kleinberger G; Metabolic Biochemistry, Biomedical Center, Faculty of Medicine, Ludwig-Maximilians-Universität München, 80539 Munich, Germany.; Munich Cluster for Systems Neurology, 81377 Munich, Germany., Haass C; German Center for Neurodegenerative Diseases, 81377 Munich, Germany.; Metabolic Biochemistry, Biomedical Center, Faculty of Medicine, Ludwig-Maximilians-Universität München, 80539 Munich, Germany.; Munich Cluster for Systems Neurology, 81377 Munich, Germany., Kahle PJ; German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany.; Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tübingen, 72076 Tübingen, Germany., Staufenbiel M; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, 72076 Tübingen, Germany.; German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany., Ping L; Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322., Duong DM; Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322., Levey AI; Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322., Seyfried NT; Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322., Lichtenthaler SF; German Center for Neurodegenerative Diseases, 81377 Munich, Germany.; Neuroproteomics, School of Medicine, Klinikum Rechts der Isar, Technische Universität München, 80333 Munich, Germany.; Munich Cluster for Systems Neurology, 81377 Munich, Germany., Jucker M; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, 72076 Tübingen, Germany.; German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany., Kaeser SA; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, 72076 Tübingen, Germany.; German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Jun 14; Vol. 119 (24), pp. e2119804119. Date of Electronic Publication: 2022 Jun 06.

Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk.

Autor: Ali M; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America.; Neurogenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, United States of America., Sung YJ; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America.; Neurogenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, United States of America., Wang F; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America.; Neurogenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, United States of America., Fernández MV; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America.; Neurogenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, United States of America., Morris JC; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America.; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, United States of America., Fagan AM; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America.; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, United States of America., Blennow K; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden., Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, United Kingdom.; UK Dementia Research Institute at UCL, London, United Kingdom., Heslegrave A; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, United Kingdom.; UK Dementia Research Institute at UCL, London, United Kingdom., Johansson PM; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, United Kingdom.; UK Dementia Research Institute at UCL, London, United Kingdom.; Department of Anesthesiology and Intensive Care Medicine, Sahlgrenska University Hospital, Mölndal, Sweden.; Institute of Clinical Sciences, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden., Svensson J; Department of Internal Medicine, Institute of Medicine, The Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden., Nellgård B; Department of Internal Medicine, Institute of Medicine, The Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden., Lleó A; Neurology Department, Hospital de Sant Pau, Barcelona, Spain., Alcolea D; Neurology Department, Hospital de Sant Pau, Barcelona, Spain., Clarimon J; Neurology Department, Hospital de Sant Pau, Barcelona, Spain., Rami L; IDIBAPS, Alzheimer´s Disease and Other Cognitive Disorders Unit, Neurology Service, ICN Hospital Clinic, Barcelona, Spain., Molinuevo JL; IDIBAPS, Alzheimer´s Disease and Other Cognitive Disorders Unit, Neurology Service, ICN Hospital Clinic, Barcelona, Spain.; Alzheimer´s Disease and Other Cognitive Disorders Unit, Neurology Service, ICN Hospital Clinic i Universitari, Barcelona, Spain.; BarcelonaBeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain., Suárez-Calvet M; BarcelonaBeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.; Biomedical Center (BMC), Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Morenas-Rodríguez E; Biomedical Center (BMC), Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Kleinberger G; Biomedical Center (BMC), Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Haass C; Biomedical Center (BMC), Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Ewers M; Institute for Stroke and Dementia Research, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany., Levin J; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany., Farlow MR; Indiana Alzheimer Disease Research Center, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America., Perrin RJ; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America.; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, United States of America.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, United States of America.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America.; Neurogenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, United States of America.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, United States of America.

Publikováno v: PloS one [PLoS One] 2022 May 26; Vol. 17 (5), pp. e0267298. Date of Electronic Publication: 2022 May 26 (Print Publication: 2022).

Chronic PPARγ Stimulation Shifts Amyloidosis to Higher Fibrillarity but Improves Cognition.

Autor: Blume T; DZNE - German Center for Neurodegenerative Diseases, Munich, Germany., Deussing M; Department of Nuclear Medicine, University Hospital of Munich, Ludwig Maximilian University of Munich, Munich, Germany., Biechele G; Department of Radiology, University Hospital of Munich, Ludwig Maximilian University of Munich, Munich, Germany., Peters F; DZNE - German Center for Neurodegenerative Diseases, Munich, Germany., Zott B; Institute of Neuroscience, Technical University of Munich, Munich, Germany.; Department of Diagnostic and Interventional Neuroradiology, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany., Schmidt C; Department of Nuclear Medicine, University Hospital of Munich, Ludwig Maximilian University of Munich, Munich, Germany., Franzmeier N; Institute for Stroke and Dementia Research, University Hospital of Munich, Ludwig Maximilian University of Munich, Munich, Germany., Wind K; DZNE - German Center for Neurodegenerative Diseases, Munich, Germany.; Department of Nuclear Medicine, University Hospital of Munich, Ludwig Maximilian University of Munich, Munich, Germany., Eckenweber F; Department of Nuclear Medicine, University Hospital of Munich, Ludwig Maximilian University of Munich, Munich, Germany., Sacher C; Department of Nuclear Medicine, University Hospital of Munich, Ludwig Maximilian University of Munich, Munich, Germany., Shi Y; DZNE - German Center for Neurodegenerative Diseases, Munich, Germany., Ochs K; DZNE - German Center for Neurodegenerative Diseases, Munich, Germany., Kleinberger G; Metabolic Biochemistry, Faculty of Medicine, Biomedical Center (BMC), Ludwig Maximilian University of Munich, Munich, Germany.; ISAR Bioscience GmbH, Planegg, Germany., Xiang X; Metabolic Biochemistry, Faculty of Medicine, Biomedical Center (BMC), Ludwig Maximilian University of Munich, Munich, Germany., Focke C; Department of Nuclear Medicine, University Hospital of Munich, Ludwig Maximilian University of Munich, Munich, Germany., Lindner S; Department of Nuclear Medicine, University Hospital of Munich, Ludwig Maximilian University of Munich, Munich, Germany., Gildehaus FJ; Department of Nuclear Medicine, University Hospital of Munich, Ludwig Maximilian University of Munich, Munich, Germany., Beyer L; Department of Nuclear Medicine, University Hospital of Munich, Ludwig Maximilian University of Munich, Munich, Germany., von Ungern-Sternberg B; Department of Nuclear Medicine, University Hospital of Munich, Ludwig Maximilian University of Munich, Munich, Germany., Bartenstein P; Department of Nuclear Medicine, University Hospital of Munich, Ludwig Maximilian University of Munich, Munich, Germany., Baumann K; Roche Pharma Research and Early Development, Neuroscience Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Adelsberger H; Department of Radiology, University Hospital of Munich, Ludwig Maximilian University of Munich, Munich, Germany., Rominger A; SyNergy, Ludwig Maximilian University of Munich, Munich, Germany.; Department of Nuclear Medicine, Inselspital Bern, Bern, Switzerland., Cumming P; Department of Nuclear Medicine, University Hospital of Munich, Ludwig Maximilian University of Munich, Munich, Germany.; School of Psychology and Counselling, Queensland University of Technology, Brisbane, QLD, Australia., Willem M; Metabolic Biochemistry, Faculty of Medicine, Biomedical Center (BMC), Ludwig Maximilian University of Munich, Munich, Germany., Dorostkar MM; DZNE - German Center for Neurodegenerative Diseases, Munich, Germany.; Center for Neuropathology and Prion Research, Ludwig Maximilian University of Munich, Munich, Germany., Herms J; DZNE - German Center for Neurodegenerative Diseases, Munich, Germany.; SyNergy, Ludwig Maximilian University of Munich, Munich, Germany.; Center for Neuropathology and Prion Research, Ludwig Maximilian University of Munich, Munich, Germany., Brendel M; DZNE - German Center for Neurodegenerative Diseases, Munich, Germany.; Department of Nuclear Medicine, University Hospital of Munich, Ludwig Maximilian University of Munich, Munich, Germany.; SyNergy, Ludwig Maximilian University of Munich, Munich, Germany.

Publikováno v: Frontiers in aging neuroscience [Front Aging Neurosci] 2022 Mar 30; Vol. 14, pp. 854031. Date of Electronic Publication: 2022 Mar 30 (Print Publication: 2022).