Výsledky vyhledávání - "Klein Scott I"

Optimization of the beta-aminoester class of factor Xa inhibitors. Part 1: P(4) and side-chain modifications for improved in vitro potency

Autor: Daniel L Cheney, Pauls Henry W, Christopher T Dunwiddie, Gardner Charles J, Kevin R. Guertin, Spada Alfred P, Allison L Zulli, Robert J. Leadley, Klein Scott I, Karen Brown, Valeria Chu, Dennis J Colussi, Mark Czekaj

Publikováno v: Bioorganicmedicinal chemistry letters. 12(12)

A systematic modification of the C(3) side-chain of the beta-aminoester class of factor Xa inhibitors and a survey of P(4) variations is described. These changes have resulted in the identification of sub-nanomolar inhibitors with improved selectivit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3bd4141e19391535969ad9d657c31ec
https://pubmed.ncbi.nlm.nih.gov/12039586

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Superiority of enoxaparin over heparin in combination with a GPIIb/IIIa receptor antagonist during coronary thrombolysis in dogs

Autor: Suzanne R Morgan, Sam S. Rebello, Charles J Kasiewski, Valeria Chu, Mark H Perrone, Ross G. Bentley, Jeffrey S Bostwick, Robert J. Leadley, Klein Scott I

Publikováno v: Thrombosis research. 102(3)

It is known that a low-molecular-weight heparin (LMWH) is more effective than unfractionated heparin in unstable angina/non-Q-wave myocardial infarction (UA/NQMI) and the platelet GPIIb/IIIa receptors play an important role in acute myocardial infarc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de280b05cd404f0bef47166512638190
https://pubmed.ncbi.nlm.nih.gov/11369420

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Crystal structures of human factor Xa complexed with potent inhibitors

Autor: Yong Mi Choi-Sledeski, Stéphanie Pouzieux, and Alfred P. Spada, Sébastien Maignan, Vincent Mikol, William R. Ewing, Pauls Henry W, Michael R. Becker, Klein Scott I, Jean-Pierre Guilloteau

Publikováno v: Journal of medicinal chemistry. 43(17)

Involved in the coagulation cascade, factor Xa (FXa) is a serine protease which has received great interest as a potential target for the development of new antithrombotics. Although there is a great wealth of structural data on thrombin complexes, f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384b2cbf131d09fbd932ead65d52fa9f
https://pubmed.ncbi.nlm.nih.gov/10966741

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