RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response

Autor: Penn-Nicholson, A, Mbandi, SK, Thompson, E, Mendelsohn, SC, Suliman, S, Chegou, NN, Malherbe, ST, Darboe, F, Erasmus, M, Hanekom, WA, Bilek, N, Fisher, M, Kaufmann, SHE, Winter, J, Murphy, M, Wood, R, Morrow, C, Van Rhijn, I, Moody, B, Murray, M, Andrade, BB, Sterling, TR, Sutherland, J, Naidoo, K, Padayatchi, N, Walzl, G, Hatherill, M, Zak, D, Scriba, TJ, Kafaar, F, Workman, L, Mulenga, H, Hughes, EJ, Xasa, O, Veldsman, A, Cloete, Y, Abrahams, D, Moyo, S, Gelderbloem, S, Tameris, M, Geldenhuys, H, Ehrlich, R, Verver, S, Geiter, L, Black, GF, van der Spuy, G, Stanley, K, Kriel, M, Du Plessis, N, Nene, N, Roberts, T, Kleynhans, L, Gutschmidt, A, Smith, B, Loxton, AG, Tromp, G, Tabb, D, Ottenhoff, THM, Klein, MR, Haks, MC, Franken, KLMC, Geluk, A, van Meijgaarden, KE, Joosten, SA, Boom, WH, Thiel, B, Mayanja-Kizza, H, Joloba, M, Zalwango, S, Nsereko, M, Okwera, B, Kisingo, H, Parida, SK, Golinski, R, Maertzdorf, J, Weiner, J, Jacobson, M, Dockrell, H, Smith, S, Gorak-Stolinska, P, Hur, YG, Lalor, M, Lee, JS, Crampin, AC, French, N, Ngwira, B, Ben-Smith, A, Watkins, K, Ambrose, L, Simukonda, F, Mvula, H, Chilongo, F, Saul, J, Branson, K, Mahomed, H, Downing, K

Publikováno v: Scientific reports
Scientific reports, vol 10, iss 1
Scientific Reports
Scientific reports, 10(1):8629. Nature Publishing Group
Scientific Reports, Vol 10, Iss 1, Pp 1-21 (2020)
Scientific Reports, 10(1). NATURE PUBLISHING GROUP
Scientific Reports, 10(1). NLM (Medline)
Scientific Reports, 10(1):8629. Nature Publishing Group

Improved tuberculosis diagnostics and tools for monitoring treatment response are urgently needed. We developed a robust and simple, PCR-based host-blood transcriptomic signature, RISK6, for multiple applications: identifying individuals at risk of i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72b4b335a138b78e75f4f968504b069
https://researchonline.lshtm.ac.uk/id/eprint/4656993/1/s41598-020-65043-8.pdf

The National Immunisation Programme in the Netherlands. Developments in 2006

Autor: Abbink F, Avoort HGAM van der, Berbers WAM, Binnendijk RS van, Boot HJ, Duynhoven YTHP van, Geraedts JLE, Gerritsen AAM, Greeff SC de, Hofhuis A, Hahne SJM, Kemmeren JM, Kimman TG, Klein MR, Koedijk FDH, Koopmans MPG, Kremer K, Maas NAT van der, Mangen MJJ, Meijer A, Mooi FR, Mylius SD, Notermans DW, Op de Coul ELM, Sande MAB van der, Schouls LM, Soolingen D van, Steenbergen JE van, Vermeer-de Bondt PE, Wallinga J, Wit GA de, Melker HE de, EPI

In 2006 several changes were made in the Dutch National Immunisation Programme (NIP): Hepatitis B vaccination at birth was added for children born to mothers positive for hepatitis B surface antigen; a new vaccine for diphtheria, tetanus, pertussis (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::6716bac704a571165c77df77156eebf9
http://hdl.handle.net/10029/13382

Expression of the IL-6 gene induces differentiation of a human monoclonal EBV-transformed B cell line

Autor: Gj, Jochems, Richard Bende, Klein MR, Wp, Zeijlemaker, Ra, Lier

Publikováno v: Europe PubMed Central

To study the role of interleukin (IL)-6 as a growth and differentiation factor for Epstein-Barr virus (EBV)-transformed B lymphocytes, we transfected the cDNA coding for human IL-6 in a monoclonal IgG1-secreting EBV B cell line. Two independent clone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ed20efa41dbba573ce91d4a16e8a8cdb
https://pubmed.ncbi.nlm.nih.gov/8395233

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