RNA and condensates: Disease implications and therapeutic opportunities.

Autor: Han TW; Dewpoint Therapeutics, Boston, MA, USA., Portz B; Dewpoint Therapeutics, Boston, MA, USA., Young RA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Boija A; Dewpoint Therapeutics, Boston, MA, USA. Electronic address: aboija@dewpointx.com., Klein IA; Dewpoint Therapeutics, Boston, MA, USA. Electronic address: iklein@dewpointx.com.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2024 Sep 19; Vol. 31 (9), pp. 1593-1609.

CD-CODE: crowdsourcing condensate database and encyclopedia.

Autor: Rostam N; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.; Center for Systems Biology Dresden, Dresden, Germany., Ghosh S; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.; Center for Systems Biology Dresden, Dresden, Germany., Chow CFW; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.; Center for Systems Biology Dresden, Dresden, Germany.; Cluster of Excellence Physics of Life, TU Dresden, Dresden, Germany., Hadarovich A; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.; Center for Systems Biology Dresden, Dresden, Germany., Landerer C; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.; Center for Systems Biology Dresden, Dresden, Germany., Ghosh R; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.; Center for Systems Biology Dresden, Dresden, Germany., Moon H; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany., Hersemann L; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany., Mitrea DM; Dewpoint Therapeutics, Boston, MA, USA., Klein IA; Dewpoint Therapeutics, Boston, MA, USA., Hyman AA; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.; Center for Systems Biology Dresden, Dresden, Germany.; Cluster of Excellence Physics of Life, TU Dresden, Dresden, Germany., Toth-Petroczy A; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany. toth-petroczy@mpi-cbg.de.; Center for Systems Biology Dresden, Dresden, Germany. toth-petroczy@mpi-cbg.de.; Cluster of Excellence Physics of Life, TU Dresden, Dresden, Germany. toth-petroczy@mpi-cbg.de.

Publikováno v: Nature methods [Nat Methods] 2023 May; Vol. 20 (5), pp. 673-676. Date of Electronic Publication: 2023 Apr 06.

Modulating biomolecular condensates: a novel approach to drug discovery.

Autor: Mitrea DM; Dewpoint Therapeutics, Boston, MA, USA., Mittasch M; Dewpoint Therapeutics, Dresden, Germany., Gomes BF; Dewpoint Therapeutics, Dresden, Germany., Klein IA; Dewpoint Therapeutics, Boston, MA, USA. iklein@dewpointx.com., Murcko MA; Dewpoint Therapeutics, Boston, MA, USA. mmurcko@dewpointx.com.

Publikováno v: Nature reviews. Drug discovery [Nat Rev Drug Discov] 2022 Nov; Vol. 21 (11), pp. 841-862. Date of Electronic Publication: 2022 Aug 16.

Predicting master transcription factors from pan-cancer expression data.

Autor: Reddy J; Women's Cancer Research Program at the Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Fonseca MAS; Women's Cancer Research Program at the Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Corona RI; Women's Cancer Research Program at the Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Nameki R; Women's Cancer Research Program at the Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Segato Dezem F; Women's Cancer Research Program at the Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Klein IA; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Chang H; Women's Cancer Research Program at the Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Chaves-Moreira D; Penn Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, PA, USA., Afeyan LK; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Malta TM; Henry Ford Hospital, Detroit, MI, USA., Lin X; Women's Cancer Research Program at the Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Abbasi F; Women's Cancer Research Program at the Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Font-Tello A; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA., Sabedot T; Henry Ford Hospital, Detroit, MI, USA., Cejas P; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA., Rodríguez-Malavé N; Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Seo JH; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA., Lin DC; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Matulonis U; Division of Gynecologic Oncology, Dana Farber Cancer Institute, Boston, MA, USA., Karlan BY; Women's Cancer Research Program at the Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Cancer Population Genetics, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Gayther SA; Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Pasaniuc B; Bioinformatics Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Computational Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Gusev A; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.; McGraw/Patterson Center for Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA., Noushmehr H; Henry Ford Hospital, Detroit, MI, USA., Long H; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA., Freedman ML; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.; The Eli and Edythe L. Broad Institute, Cambridge, MA, USA., Drapkin R; Penn Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, PA, USA., Young RA; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, M.I.T., Cambridge, MA, USA., Abraham BJ; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Lawrenson K; Women's Cancer Research Program at the Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Publikováno v: Science advances [Sci Adv] 2021 Nov 26; Vol. 7 (48), pp. eabf6123. Date of Electronic Publication: 2021 Nov 24.

Impact of COVID-19 on Patients with Cancer Receiving Immune Checkpoint Inhibitors.

Autor: Bui AN; Harvard Medical School, Boston, MA, USA., Tyan K; Harvard Medical School, Boston, MA, USA., Giobbie-Hurder A; Division of Biostatistics, Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA., Klein IA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Whitehead Institute of Biomedical Research, Cambridge, MA, USA., Manos MP; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Zubiri L; Department of Medical Oncology, Massachusetts General Hospital, Boston, MA, USA., Reynolds K; Department of Medical Oncology, Massachusetts General Hospital, Boston, MA, USA., Grover S; Harvard Medical School, Boston, MA, USA.; Department of Medicine, Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA, USA., Weinhouse GL; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA., Ott PA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., LeBoeuf NR; Harvard Medical School, Boston, MA, USA.; Department of Dermatology, Center for Cutaneous Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA, USA., Rahma O; Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Publikováno v: Journal of immunotherapy and precision oncology [J Immunother Precis Oncol] 2021 May 14; Vol. 4 (2), pp. 35-44. Date of Electronic Publication: 2021 May 14 (Print Publication: 2021).