Multimodal detection of dopamine by sniffer cells expressing genetically encoded fluorescent sensors.

Autor: Klein Herenbrink C; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Støier JF; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Reith WD; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Dagra A; College of Medicine, University of Florida, Gainesville, FL, 32611, USA., Gregorek MAC; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Cola RB; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Patriarchi T; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich, University and ETH Zurich, Zurich, Switzerland., Li Y; State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, 100871, Beijing, China.; PKU-IDG/McGovern Institute for Brain Research, 100871, Beijing, China.; Peking-Tsinghua Center for Life Sciences, 100871, Beijing, China., Tian L; Departments of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, Davis, CA, USA., Gether U; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Herborg F; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. frejahh@sund.ku.dk.

Publikováno v: Communications biology [Commun Biol] 2022 Jun 10; Vol. 5 (1), pp. 578. Date of Electronic Publication: 2022 Jun 10.

Novel Fluorescent Ligands Enable Single-Molecule Localization Microscopy of the Dopamine Transporter.

Autor: Guthrie DA; Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States., Klein Herenbrink C; Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark., Lycas MD; Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark., Ku T; Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States., Bonifazi A; Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States., DeVree BT; Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark., Mathiasen S; Department of Psychiatry, Columbia University Vagelos College of Physicians & Surgeon and Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York 10032, United States., Javitch JA; Department of Psychiatry, Columbia University Vagelos College of Physicians & Surgeon and Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York 10032, United States., Grimm JB; Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia 20147, United States., Lavis L; Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia 20147, United States., Gether U; Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark., Newman AH; Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States.

Publikováno v: ACS chemical neuroscience [ACS Chem Neurosci] 2020 Oct 21; Vol. 11 (20), pp. 3288-3300. Date of Electronic Publication: 2020 Oct 01.

Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole.

Autor: Klein Herenbrink C, Verma R; Computational Chemistry and Molecular Biophysics Unit, National Institute on Drug Abuse-Intramural Research Program , National Institutes of Health , 333 Cassell Drive , Baltimore , Maryland 21224 , United States., Lim HD, Kopinathan A, Keen A, Shonberg J, Draper-Joyce CJ, Scammells PJ, Christopoulos A, Javitch JA, Capuano B, Shi L; Computational Chemistry and Molecular Biophysics Unit, National Institute on Drug Abuse-Intramural Research Program , National Institutes of Health , 333 Cassell Drive , Baltimore , Maryland 21224 , United States., Lane JR; Division of Pharmacology, Physiology and Neuroscience, School of Life Sciences, Queen's Medical Centre , University of Nottingham , Nottingham NG7 2UH , U.K.; Centre of Membrane Protein and Receptors , Universities of Birmingham and Nottingham , Nottingham , United Kingdom.

Publikováno v: ACS chemical biology [ACS Chem Biol] 2019 Aug 16; Vol. 14 (8), pp. 1780-1792. Date of Electronic Publication: 2019 Aug 05.

The action of a negative allosteric modulator at the dopamine D 2 receptor is dependent upon sodium ions.

Autor: Draper-Joyce CJ; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, Parkville, VIC 3052, Australia., Verma RK; Computational Chemistry and Molecular Biophysics Unit, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland, 21224, United States., Michino M; Computational Chemistry and Molecular Biophysics Unit, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland, 21224, United States.; Tri-Institutional Therapeutics Discovery Institute, 413 E 69th St, New York, NY, 10021, United States., Shonberg J; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, Parkville, VIC 3052, Australia., Kopinathan A; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, Parkville, VIC 3052, Australia., Klein Herenbrink C; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, Parkville, VIC 3052, Australia., Scammells PJ; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, Parkville, VIC 3052, Australia., Capuano B; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, Parkville, VIC 3052, Australia., Abramyan AM; Computational Chemistry and Molecular Biophysics Unit, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland, 21224, United States., Thal DM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, Parkville, VIC 3052, Australia., Javitch JA; Departments of Psychiatry and Pharmacology, New York State Psychiatric Institute, New York, New York, 10032, United States.; College of Physicians and Surgeons, Columbia University, and Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York, 10032, United States., Christopoulos A; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, Parkville, VIC 3052, Australia., Shi L; Computational Chemistry and Molecular Biophysics Unit, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland, 21224, United States. lei.shi2@nih.gov., Lane JR; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, Parkville, VIC 3052, Australia. rob.lane@monash.edu.

Publikováno v: Scientific reports [Sci Rep] 2018 Jan 19; Vol. 8 (1), pp. 1208. Date of Electronic Publication: 2018 Jan 19.

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission.

Autor: Yarwood RE; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.; The Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia., Imlach WL; Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC 3800, Australia.; Department of Physiology, Monash University, Melbourne, VIC 3800, Australia., Lieu T; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.; The Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia., Veldhuis NA; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.; The Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia., Jensen DD; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.; The Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia., Klein Herenbrink C; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.; The Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia., Aurelio L; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.; The Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia., Cai Z; Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC 3800, Australia.; Department of Physiology, Monash University, Melbourne, VIC 3800, Australia., Christie MJ; Discipline of Pharmacology, University of Sydney, Sydney, NSW 2006, Australia., Poole DP; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.; The Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.; Department of Anatomy and Cell Biology, University of Melbourne, Parkville, VIC 3010, Australia., Porter CJH; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.; The Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia., McLean P; Takeda Pharmaceuticals Inc., Cambridge, MA 02139., Hicks GA; Takeda Pharmaceuticals Inc., Cambridge, MA 02139., Geppetti P; Department of Health Sciences, Clinical Pharmacology Unit, University of Florence, 50139 Florence, Italy., Halls ML; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.; The Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia., Canals M; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia; meri.canals@monash.edu nb2733@cumc.columbia.edu.; The Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia., Bunnett NW; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia; meri.canals@monash.edu nb2733@cumc.columbia.edu.; The Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.; Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, VIC 3010, Australia.; Department of Surgery, Columbia University, New York, NY 10032.; Department of Pharmacology, Columbia University, New York, NY 10032.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Nov 14; Vol. 114 (46), pp. 12309-12314. Date of Electronic Publication: 2017 Oct 30.