Zobrazeno 1 - 10
of 500
pro vyhledávání: '"Klein, Jacob A."'
Autor:
Jin, Di, Klein, Jacob
The outstanding lubrication of articular cartilage in the major synovial joints such as hips and knees, essential for the joint well-being, has been attributed to boundary layers of lipids at the outer cartilage surfaces, which have very low friction
Externí odkaz:
http://arxiv.org/abs/2404.06074
Healthy articular cartilage has excellent lubricating properties, with friction coefficients reaching extremely low values at physiological pressures. Such high-performing lubricating layer in joints is attributed to the surface hydration arising fro
Externí odkaz:
http://arxiv.org/abs/2404.05234
Fusion of lipid bilayers in membranes is important in processes from vesicle-cell interactions (as in drug delivery) to exosome-cell signaling, while transient transmembrane electric fields are known to occur spontaneously. Two contacting phosphatidy
Externí odkaz:
http://arxiv.org/abs/2404.05035
Liposomic lubricants suppress shear-stress induced inflammatory gene regulation in the joint in vivo
Autor:
Zhu, Linyi, Lin, Weifeng, Kluzek, Monika, Miotla-Zarebska, Jadwiga, Batchelor, Vicky, Gardiner, Matthew, Chan, Chris, Culmer, Peter, Chanalaris, Anastasios, Goldberg, Ronit, Klein, Jacob, Vincent, Tonia L.
Osteoarthritis (OA) is a widespread, debilitating joint disease associated with articular cartilage degradation. It is driven via mechano-inflammatory catabolic pathways, presumed up-regulated due to increased shear stress on the cartilage-embedded c
Externí odkaz:
http://arxiv.org/abs/2312.05811
Autor:
Lin, Weifeng, Klein, Jacob
Healthy articular cartilage, covering the ends of bones in major joints such as hips and knees, presents the most efficiently-lubricated surface known in nature, with friction coefficients as low as 0.001 up to physiologically high pressures. Such lo
Externí odkaz:
http://arxiv.org/abs/2311.02681
The low sliding friction of articular cartilage in the major joints , which is crucial for its homeostasis and for joint health, has been attributed to lipid bilayers forming lubricious boundary layers at its surface. The robustness of such layers, a
Externí odkaz:
http://arxiv.org/abs/2309.00935
Transient electric fields across cell bilayer membranes can lead to electroporation, as well as to cell fusion, and have been extensively studied. We find that transmembrane electric fields similar to those in cells can lead to a massive, reversible
Externí odkaz:
http://arxiv.org/abs/2305.19178
The very low sliding friction of articular cartilage in the major synovial joints such as hips and knees is crucial for their well-being, and has been attributed to lubrication by phospholipid boundary layers. While single-component lipid layers have
Externí odkaz:
http://arxiv.org/abs/2305.12382
Autor:
Jin, Di, Klein, Jacob
It was recently discovered that friction between surfaces bearing phosphatidylcholine (PC) lipid bilayers can be increased by two orders of magnitude or more via an externally-applied electric field, and that this increase is fully reversible when th
Externí odkaz:
http://arxiv.org/abs/2303.08555
It is well known that lipid membranes respond to a threshold transmembrane electric field through a reversible mechanism called electroporation, where hydrophilic water pores form across the membrane, an effect widely used in biological systems. The
Externí odkaz:
http://arxiv.org/abs/2303.08551