Paternally inherited cis-regulatory structural variants are associated with autism.

Autor: Brandler WM; Beyster Center for Genomics of Psychiatric Diseases, University of California San Diego, La Jolla, CA 92093, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.; Department of Cellular and Molecular Medicine and Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.; Human Longevity, Inc., San Diego, CA 92121, USA., Antaki D; Beyster Center for Genomics of Psychiatric Diseases, University of California San Diego, La Jolla, CA 92093, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.; Department of Cellular and Molecular Medicine and Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.; Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, CA 92093, USA., Gujral M; Beyster Center for Genomics of Psychiatric Diseases, University of California San Diego, La Jolla, CA 92093, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.; Department of Cellular and Molecular Medicine and Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., Kleiber ML; Beyster Center for Genomics of Psychiatric Diseases, University of California San Diego, La Jolla, CA 92093, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.; Department of Cellular and Molecular Medicine and Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., Whitney J; The Centre for Applied Genomics, Genetics, and Genome Biology, The Hospital for Sick Children, Toronto, Canada., Maile MS; Beyster Center for Genomics of Psychiatric Diseases, University of California San Diego, La Jolla, CA 92093, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.; Department of Cellular and Molecular Medicine and Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., Hong O; Beyster Center for Genomics of Psychiatric Diseases, University of California San Diego, La Jolla, CA 92093, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.; Department of Cellular and Molecular Medicine and Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., Chapman TR; Beyster Center for Genomics of Psychiatric Diseases, University of California San Diego, La Jolla, CA 92093, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.; Department of Cellular and Molecular Medicine and Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., Tan S; Beyster Center for Genomics of Psychiatric Diseases, University of California San Diego, La Jolla, CA 92093, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.; Department of Cellular and Molecular Medicine and Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., Tandon P; Beyster Center for Genomics of Psychiatric Diseases, University of California San Diego, La Jolla, CA 92093, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.; Department of Cellular and Molecular Medicine and Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., Pang T; Beyster Center for Genomics of Psychiatric Diseases, University of California San Diego, La Jolla, CA 92093, USA.; Rady Children's Hospital, San Diego, CA 92123, USA., Tang SC; Beyster Center for Genomics of Psychiatric Diseases, University of California San Diego, La Jolla, CA 92093, USA.; Rady Children's Hospital, San Diego, CA 92123, USA., Vaux KK; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA., Yang Y; Oxford Nanopore Technologies, Inc., NY 10013, USA., Harrington E; Oxford Nanopore Technologies, Inc., NY 10013, USA., Juul S; Oxford Nanopore Technologies, Inc., NY 10013, USA., Turner DJ; Oxford Nanopore Technologies Ltd., Oxford, UK., Thiruvahindrapuram B; The Centre for Applied Genomics, Genetics, and Genome Biology, The Hospital for Sick Children, Toronto, Canada., Kaur G; The Centre for Applied Genomics, Genetics, and Genome Biology, The Hospital for Sick Children, Toronto, Canada., Wang Z; The Centre for Applied Genomics, Genetics, and Genome Biology, The Hospital for Sick Children, Toronto, Canada., Kingsmore SF; Rady Children's Institute for Genomic Medicine, Rady Children's Hospital, San Diego, CA 92123, USA., Gleeson JG; Howard Hughes Medical Institute, Rady Children's Institute of Genomic Medicine, Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA., Bisson D; Human Longevity, Inc., San Diego, CA 92121, USA., Kakaradov B; Human Longevity, Inc., San Diego, CA 92121, USA., Telenti A; Human Longevity, Inc., San Diego, CA 92121, USA., Venter JC; Human Longevity, Inc., San Diego, CA 92121, USA.; J. Craig Venter Institute, La Jolla, CA 92037, USA., Corominas R; Genetics Unit, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Barcelona, Spain., Toma C; Departament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Catalonia, Spain.; Neuroscience Research Australia, Sydney, Australia.; School of Medical Sciences, University of New South Wales, Sydney, Australia., Cormand B; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Barcelona, Spain.; Departament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Catalonia, Spain.; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Catalonia, Spain.; Institut de Recerca Sant Joan de Déu (IR-SJD), Esplugues, Catalonia, Spain., Rueda I; Department of Psychiatry, Hospital Sant Joan de Déu, Barcelona, Spain., Guijarro S; Child and Adolescent Mental Health Unit, Hospital Universitari Mútua de Terrassa, Barcelona, Spain., Messer KS; Division of Biostatistics and Bioinformatics, Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA 92093, USA., Nievergelt CM; Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA., Arranz MJ; Research Laboratory Unit, Fundacio Docencia I Recerca Mutua Terrassa, Barcelona, Spain., Courchesne E; Autism Center of Excellence, Department of Neuroscience, University of California San Diego, La Jolla, CA 92093, USA., Pierce K; Autism Center of Excellence, Department of Neuroscience, University of California San Diego, La Jolla, CA 92093, USA., Muotri AR; Department of Cellular and Molecular Medicine and Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., Iakoucheva LM; Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA., Hervas A; Child and Adolescent Mental Health Unit, Hospital Universitari Mútua de Terrassa, Barcelona, Spain., Scherer SW; The Centre for Applied Genomics, Genetics, and Genome Biology, The Hospital for Sick Children, Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Canada.; McLaughlin Centre, University of Toronto, Toronto, Canada., Corsello C; Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.; Rady Children's Hospital, San Diego, CA 92123, USA., Sebat J; Beyster Center for Genomics of Psychiatric Diseases, University of California San Diego, La Jolla, CA 92093, USA. jsebat@ucsd.edu.; Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.; Department of Cellular and Molecular Medicine and Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2018 Apr 20; Vol. 360 (6386), pp. 327-331.

Third trimester-equivalent ethanol exposure is characterized by an acute cellular stress response and an ontogenetic disruption of genes critical for synaptic establishment and function in mice.

Autor: Kleiber ML; Molecular Genetics Unit, Department of Biology, The University of Western Ontario, London, Ont., Canada., Laufer BI, Stringer RL, Singh SM

Publikováno v: Developmental neuroscience [Dev Neurosci] 2014; Vol. 36 (6), pp. 499-519. Date of Electronic Publication: 2014 Sep 30.

Long-lasting alterations to DNA methylation and ncRNAs could underlie the effects of fetal alcohol exposure in mice.

Autor: Laufer BI; Molecular Genetics Unit, Department of Biology, Western University, London, Ontario, N6A 5B7, Canada., Mantha K, Kleiber ML, Diehl EJ, Addison SM, Singh SM

Publikováno v: Disease models & mechanisms [Dis Model Mech] 2013 Jul; Vol. 6 (4), pp. 977-92. Date of Electronic Publication: 2013 Apr 10.

Long-term alterations to the brain transcriptome in a maternal voluntary consumption model of fetal alcohol spectrum disorders.

Autor: Kleiber ML; Molecular Genetics Unit, Department of Biology, University of Western Ontario, London, Ontario, Canada N6A 5B7., Laufer BI, Wright E, Diehl EJ, Singh SM

Publikováno v: Brain research [Brain Res] 2012 Jun 06; Vol. 1458, pp. 18-33. Date of Electronic Publication: 2012 Apr 17.

Delineation of the role of nicotinic acetylcholine receptor genes in alcohol preference in mice.

Autor: Symons MN; Molecular Genetics Unit, Department of Biology, University of Western Ontario, London, ON N6A 5B7, Canada., Weng J, Diehl E, Heo E, Kleiber ML, Singh SM

Publikováno v: Behavior genetics [Behav Genet] 2010 Sep; Vol. 40 (5), pp. 660-71. Date of Electronic Publication: 2010 May 23.