Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Kleemann Heinz-Werner"'
Autor:
Di Sario, Antonio, Bendia, Emanuele, Taffetani, Silvia, Marzioni, Marco, Candelaresi, Cinzia, Pigini, Paola, Schindler, Ursula, Kleemann, Heinz-Werner, Trozzi, Luciano, Macarri, Giampiero, Benedetti, Antonio
Publikováno v:
In Hepatology 2003 37(2):256-266
Autor:
Bernard Pirard, Carsten Struebing, Joachim Brendel, Kleemann Heinz-Werner, Thomas Boehme, Stefan Peukert, Horst Hemmerle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2823-2827
The search for novel, potent Kv1.5 blockers based on an anthranilic amide scaffold employing a pharmacophore-based virtual screening approach is described. The synthesis and structure-activity relationships (SAR) with respect to inhibition of the Kv1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ab5cedd3a9e5edcb8406ba2c4f6548
https://doi.org/10.1016/j.bmcl.2004.03.057
https://doi.org/10.1016/j.bmcl.2004.03.057
Autor:
Antonio Di Sario, Marco Marzioni, Antonio Benedetti, Paola Pigini, Cinzia Candelaresi, Silvia Taffetani, Ursula Schindler, Giampiero Macarri, Kleemann Heinz-Werner, Luciano Trozzi, Emanuele Bendia
Publikováno v:
Hepatology. 37:256-266
The aim of this study was to evaluate the effect of cariporide, a selective Na(+)/H(+) exchange inhibitor, on isolated and cultured hepatic stellate cells (HSCs) and in 2 in vivo models of rat liver fibrosis. Platelet-derived growth factor (PDGF)-ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6e7e569f2914febaf9dc75329081685
https://doi.org/10.1053/jhep.2003.50028
https://doi.org/10.1053/jhep.2003.50028
Autor:
Bernard Pirard, Horst Hemmerle, Peter Below, Andrea Brüggemann, Wolfgang Schmidt, Joachim Brendel, Stefan Peukert, Kleemann Heinz-Werner
Publikováno v:
Journal of Medicinal Chemistry. 46:486-498
The voltage-gated potassium channel Kv1.5 is regarded as a promising target for the development of new atrial selective drugs with fewer side effects. In the present study the discovery of ortho,ortho-disubstituted bisaryl compounds as blockers of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fac76eb36f5a5cefbf2c6cda966a56a
https://doi.org/10.1021/jm0210461
https://doi.org/10.1021/jm0210461
Autor:
Werner Dittrich, Carsten Strübing, Kleemann Heinz-Werner, Matthias Löhn, Hartmut Rütten, Susanne Miehe, Peter Dr. Crause, Thomas Licher, Thorsten Schmidt
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35393 (2012)
PLoS ONE
PLoS ONE
TRPC channels are a family of nonselective cation channels that regulate ion homeostasis and intracellular Ca(2+) signaling in numerous cell types. Important physiological functions such as vasoregulation, neuronal growth, and pheromone recognition h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c78120440a8e5314045326225826682
http://europepmc.org/articles/PMC3328449?pdf=render
http://europepmc.org/articles/PMC3328449?pdf=render
Autor:
Frank Girbig, Adalbert Wagner, Werner Kramer, Irina Leipe, Kleemann Heinz-Werner, Hansjoerg Urbach, Ulrike Gutjahr
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1027:25-30
The interaction of two renin inhibitors, S 86 2033 and S 86 3390, with the uptake system for β-lactam antibiotics and small peptides in the brush border membrane of enterocytes from rabbit small intestine was investigated using brush border membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7749ff0a89c3a568e5e60aceb656296
https://doi.org/10.1016/0005-2736(90)90043-n
https://doi.org/10.1016/0005-2736(90)90043-n
Publikováno v:
Bioorganicmedicinal chemistry. 5(4)
The synthesis and the SAR study of imidazo[4,5-b]pyridine biphenyl sulfonylureas and -carbamates as highly potent AT1-selective ANG II receptor antagonists are described. Several members of this new class of antagonists efficiently inhibited the ANG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d92e69971df59ddf3474e5aca0f41547
https://pubmed.ncbi.nlm.nih.gov/9158865
https://pubmed.ncbi.nlm.nih.gov/9158865
Autor:
Wolfgang Linz, Kleemann Heinz-Werner, Holger Heitsch, Rainer Henning, Wolf Ulrich Nickel, Hansjoerg Urbach, Adalbert Wagner, Dieter Ruppert
Publikováno v:
Journal of medicinal chemistry. 36(19)
Based on the concept of transition-state analogs, a series of nonpeptide renin inhibitors with the new (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-(2-pyridyl)hexane moiety at the C-terminal functionality were synthesized and evaluated for inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26313941b4d970e7c38a538192d17a8f
https://pubmed.ncbi.nlm.nih.gov/8410992
https://pubmed.ncbi.nlm.nih.gov/8410992
Akademický článek
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Autor:
Luciano Trozzi, F. Ridolfi, Ursula Schindler, Emanuele Bendia, Antonio Benedetti, Cinzia Candelaresi, Kleemann Heinz-Werner, Paola Sterpetti, Antonio Di Sario, Silvia Taffetani, Gianluca Svegliati-Baroni
Publikováno v:
Journal of Hepatology. 36:70
Results: We demonstrate 1) That both core tumour and non-tumourderived sequences inhibit the global antiviral effects of IFNa on VSV and EMCV replication in Ratl and HuH7 cells and sensitize Ref cells to transformation, in cooperation with ras oncoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adbc3dd35605a21288d371cea806bc9e
https://doi.org/10.1016/s0168-8278(02)80234-3
https://doi.org/10.1016/s0168-8278(02)80234-3