Detrimental Role for Human High Temperature Requirement Serine Protease A1 (HTRA1) in the Pathogenesis of Intervertebral Disc (IVD) Degeneration

Autor: Tiaden, André N., Klawitter, Marina, Lux, Vanda, Mirsaidi, Ali, Bahrenberg, Gregor, Glanz, Stephan, Quero, Lilian, Liebscher, Thomas ^**, Wuertz, Karin, Ehrmann, Michael, Richards, Peter J.

Publikováno v: In Journal of Biological Chemistry 15 June 2012 287(25):21335-21345

Curcuma DMSO extracts and curcumin exhibit an anti-inflammatory and anti-catabolic effect on human intervertebral disc cells, possibly by influencing TLR2 expression and JNK activity

Autor: Klawitter Marina, Quero Lilian, Klasen Juergen, Gloess Alexia N, Klopprogge Babette, Hausmann Oliver, Boos Norbert, Wuertz Karin

Publikováno v: Journal of Inflammation, Vol 9, Iss 1, p 29 (2012)

Abstract Background As proinflammatory cytokines seem to play a role in discogenic back pain, substances exhibiting anti-inflammatory effects on intervertebral disc cells may be used as minimal-invasive therapeutics for intradiscal/epidural injection

Externí odkaz: https://doaj.org/article/cf214a7b21f944ddb0a8be831c40f763

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Human MMP28 expression is unresponsive to inflammatory stimuli and does not correlate to the grade of intervertebral disc degeneration.

Autor: Klawitter M; Spine Research Group, Competence Center for Applied Biotechnology and Molecular Medicine, University of Zurich, Zurich, Switzerland., Quero L, Bertolo A, Mehr M, Stoyanov J, Nerlich AG, Klasen J, Aebli N, Boos N, Wuertz K

Publikováno v: Journal of negative results in biomedicine [J Negat Results Biomed] 2011 Jul 29; Vol. 10, pp. 9. Date of Electronic Publication: 2011 Jul 29.