Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Klaus-Peter Gulden"'
Autor:
Karl Peters, Doris Feineis, Gerhard Bringmann, Katja Maksimenka, Jörg Mühlbacher, Miriam Münchbach, Ralf God, Kim Messer, Eva-Maria Peters, Klaus-Peter Gulden
Publikováno v:
Tetrahedron. 60:8143-8151
Separation and stereochemical attribution of the two enantiomers of the neurotoxin 1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline (TaClo) has been achieved by applying chromatography on a chiral phase HPLC column in hyphenation with circular dichr
Publikováno v:
Tetrahedron. 59:1245-1253
The first quantum chemical calculation of the circular dichroism (CD) spectra of michellamines has been achieved, based on a complete quantum chemical conformational analysis. Michellamines are dimeric naphthylisoquinoline alkaloids and thus naturall
Autor:
G. Bringmann, Robert J. Gulakowski, Kirk P. Manfredi, James B. McMahon, Yali F. Hallock, Klaus-Peter Gulden, Jin-Rui Dai, Michael R. Boyd, John H. Cardellina, Manuela Schäffer, Guido François, Martin Stahl
Publikováno v:
Journal of Natural Products. 60:677-683
New monomeric (korupensamine E, 6) and dimeric (michellamines D-F, 7-9) naphthylisoquinoline alkaloids have been isolated from extracts of the tropical liana Ancistrocladus korupensis. Structures were determined by spectroanalytical methods, and ster
Convergent Synthesis of Naphthylisoquinoline Alkaloids: Total Synthesis of (+)-O-Methylancistrocline
Autor:
Mark A. Rizzacasa, Manuela Schäffer, Phung Chau, Gerhard Bringmann, Ivona R. Czuba, Klaus-Peter Gulden
Publikováno v:
The Journal of Organic Chemistry. 61:7101-7105
A highly convergent synthesis of the methyl ether derivative 2a of the naphthylisoquinoline alkaloid ancistrocline (2) is described. The key step involves a stereoselective biaryl coupling between the chiral oxazoline 3 and the Grignard reagent 4 der
Publikováno v:
Journal of Molecular Modeling. 1:161-175
AdaptivSearch is the first adaptive strategy based algorithm for the rational and economical construction of n-dimensional hypersurfaces. AdaptivSearch works iteratively: At each step it parcels out the definition range into several triangles, evalua
Publikováno v:
Tetrahedron. 51:9353-9360
The first total synthesis of a naturally occurring dimeric carbazole alkaloid, bismurrayaquinone A ( 4 ), is described, by oxidation of dimeric O -demethylmurrayafoline A, a still hypothetic natural product recently synthesized. By chromatography on
Autor:
Klaus-Peter Gulden, Michael R. Boyd, Courtney B. Hughes, Yali F. Hallock, Gerhard Bringmann, John H. Cardellina, Manuela Schäffer
Publikováno v:
Natural Product Letters. 6:315-320
Using bioassay-guided fractionation, dioncophylline A [1] was isolated from the leaves and twigs of the tropical liana Ancistrocladus letestui Pelligr. Dioncophylline A was previously known from Triphyophyllum peltatum and A. abbreviatus. The in vitr
Autor:
John W. Blunt, Angela Y. Lee, Manuela Schaeffer, Gerhard Bringmann, Kirk P. Manfredi, John H. Cardellina, Klaus-Peter Gulden, Jon Clardy, Yali F. Hallock
Publikováno v:
The Journal of Organic Chemistry. 59:6349-6355
Autor:
Gerhard Bringmann, Hans Burzlaff, Thomas Hartung, Oliver Kröcher, Joachim Lange, Klaus-Peter Gulden
Publikováno v:
Tetrahedron. 50:2831-2840
The synthesis, enantiomer analysis, and configurational assignment of dinaphth[2,1-c: 1′,2′-e]oxepin-3-(5H)-one, a seven-membered lactone-bridged chiral binaphthalene, is reported. The elucidation of the absolute configuration has been performed,
Autor:
Bernd Kramer, John H. Cardellina, Kirk P. Manfredi, Michael R. Boyd, Jörg Fleischhauer, Gerhard Bringmann, Yali F. Hallock, Klaus-Peter Gulden
Publikováno v:
Tetrahedron. 50:7807-7814
The circular dichroic behavior of the michellamines, dimeric naphthylisoquinoline alkaloids, was investigated. Due to the molecular size and conformational flexibility, which makes direct calculations of the CD spectra very difficult, and because of