Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Klaus-Dieter Willim"'
Autor:
Klaus-Dieter Willim, Henri Doods, Wolfgang Eberlein, Wolfgang Wienen, Michael Entzeroth, Wolfhard Engel, Klaus Rudolf, Heike A. Wieland
Publikováno v:
Regulatory Peptides. 65:71-77
Based on the assumption that the pharmacophoric groups interacting with the Y1 receptor are located in the C-terminal part of neuropeptide Y, low molecular weight compounds with high affinity and selectivity for the Y1 receptor were designed and synt
Autor:
Klaus-Dieter Willim, Henri Doods, Heike A. Wieland, Wolfgang Wienen, Wolfhard Engel, Klaus Rudolf, Hans Braunger, Michael Entzeroth, Wolfgang Eberlein
Publikováno v:
European Journal of Pharmacology. 278:239-242
The binding of tritium-labelled BIBP3226, N2-(diphenylacetyl)-N-[(4-hydroxy-phenyl)methyl]-D-arginine amide, to human neuroblastoma SK-N-MC cells was investigated. [3H]BIBP3226 reversibly binds to neuropeptide Y receptors of the Y1 subtype expressed
Autor:
Hans-Ulrich Reissig, Klaus-Dieter Willim, Günther Jung, Eike Hoffmann, K. Paulini, Annette G. Beck-Sickinger, Heike A. Wieland
Publikováno v:
Biochemical Society Transactions. 22:145-149
Publikováno v:
Regulatory peptides.
At least six types of neuropeptide Y (NPY) receptors (Y1-Y6) have been pharmacologically distinguished of which only the Y1, Y2, Y4 and Y5 subtypes have been thoroughly characterized. In order to further classify receptor subtypes in the brain, we pe
Publikováno v:
Journal of peptide science : an official publication of the European Peptide Society. 1(5)
Four sets of centrally truncated analogues of neuropeptide Y have been synthesized. In each series the N-terminal part was constant, while the C-terminal segment was systematically varied in length. The C- and N-terminal parts were linked by 6-aminoh
Autor:
Klaus Rudolf, Helmut Wittneben, Annette G. Beck-Sickinger, Klaus-Dieter Willim, Heike A. Weland, Günther Jung
Publikováno v:
European journal of biochemistry. 225(3)
The synthesis of more than fifty 36-residue oligopeptide analogs of neuropeptide Y (NPY) and their affinity to human Y1 and Y2 receptors is described. Each amino acid of the natural sequence was replaced by L-alanine, the four alanine residues at pos