Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Klaus van Leyen"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
IntroductionLipoxygenases (LOXs) have essential roles in stroke, atherosclerosis, diabetes, and hypertension. 12/15-LOX inhibition was shown to reduce infarct size and brain edema in the acute phase of experimental stroke. However, the significance o
Externí odkaz:
https://doaj.org/article/81bce9e14dd14720ac89431a64d72aaf
Autor:
Wenlu Li, Emiri T. Mandeville, Violeta Durán-Laforet, Norito Fukuda, Zhanyang Yu, Yi Zheng, Aaron Held, Ji-Hyun Park, Takafumi Nakano, Masayoshi Tanaka, Jingfei Shi, Elga Esposito, Wanting Niu, Changhong Xing, Kazuhide Hayakawa, Ignacio Lizasoain, Klaus van Leyen, Xunming Ji, Brian J. Wainger, Maria A. Moro, Eng H. Lo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Damaged brains try to repair themselves by producing neurons in areas where neurogenesis does not normally occur. Here, the authors show that brain endothelial cells provide microvesicle-encased signals that convert parenchymal astrocytes into neural
Externí odkaz:
https://doaj.org/article/f63343dfedd9439ab7c83ba7559d3566
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Dual antiplatelet treatment (DAPT) increases the risk of tPA-associated hemorrhagic transformation (HT) in ischemic stroke. To investigate the effects of DAPT in rodents, reliable indicators of platelet function utilizing a minimally invasive procedu
Externí odkaz:
https://doaj.org/article/9355b93e139e47c0b526bce4bf4ff21d
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 1, Pp 113-114 (2021)
Externí odkaz:
https://doaj.org/article/96ed649a4eeb4d2e93c92ba4d1638845
Autor:
Christian Foerch, Nathanael L Rosidi, Frieder Schlunk, Arne Lauer, Flor A Cianchetti, Emiri Mandeville, Ken Arai, Kazim Yigitkanli, Xiang Fan, Xiaoying Wang, Klaus van Leyen, Helmuth Steinmetz, Chris B Schaffer, Eng H Lo
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e54203 (2013)
Tissue plasminogen activator (tPA) is the only FDA-approved treatment for reperfusing ischemic strokes. But widespread use of tPA is still limited by fears of inadvertently administering tPA in patients with intracerebral hemorrhage (ICH). Surprising
Externí odkaz:
https://doaj.org/article/d2575b99cafe4e15bee45822472139f6
Autor:
Andreia Morais, Joseph J. Locascio, Lauren H. Sansing, Jessica Lamb, Karisma Nagarkatti, Takahiko Imai, Klaus van Leyen, Jaroslaw Aronowski, James I. Koenig, Francesca Bosetti, Patrick Lyden, Cenk Ayata, Patrick D. Lyden, David C. Hess, Pradip K. Kamat, Mohammad Badruzzaman Khan, Krishnan Dhandapani, Ali S. Arbab, Shahneela Siddiqui, Cameron Smith, Mohammad Nisar, Enrique C. Leira, Anil K. Chauhan, Nirav Dhanesha, Rakesh B. Patel, Mariia Kumskova, Daniel Thedens, Kai Wang, Tao Qin, Xuyan Jin, Taylan Denis Erdogan, Lili Yu, Joseph B. Mandeville, William Taylor Kimberly, Jonah Patrick Weigand Whittier, Eng Lo, Ken Arai, Klaus Van Leyen, Fahmeed Hyder, Jelena M. Mihailovic, Basavaraju G. Sanganahalli, Sebastian Diaz-Perez, Sofia E. Velazquez, Hannah E. Beatty, Conor Johnson, Alison L. Herman, Ligia S. B. Boisserand, Emma Immakavar, Raymond C. Koehler, Ted Dawson, Valina Dawson, Yanrong Shi, Brooklyn Avery, Steven Lannon, Adnan Bibic, Kazi Akhter, Senthilkumar S. Karuppagounder, Louise D. McCullough, Lidiya Obertas, Andrew Goh, Shuning Huang, Anjali Chauhan
Publikováno v:
Stroke.
The Stroke Preclinical Assessment Network (SPAN) is a multicenter preclinical trial platform using rodent models of transient focal cerebral ischemia to address translational failure in experimental stroke. In addition to centralized randomization an
Autor:
Wei Zhao, Zhongliang Li, Guangsen Cheng, Guomin Huang, Ligong Lu, Yongkang Liu, Yu Liu, Klaus van Leyen, Meixiao Zhan, Yongjie Xin, Yong Li
Publikováno v:
Journal of Neurochemistry. 157:586-598
Thrombolytic stroke therapy with tissue plasminogen activator (tPA) is limited by risks of hemorrhagic transformation (HT). We have reported that a new 12/15-lipoxygenase (12/15-LOX) inhibitor ML351 reduced tPA related HT in mice subjected to experim
Publikováno v:
Stroke. 53
Introduction: Since 1996, no new drugs to treat ischemic stroke have gained approval by the FDA, leading to a perception in the private sector that developing a stroke drug is too risky to be worthwhile. Recognizing this Catch-22 situation, the NIH h
Autor:
Yi Zheng, Franziska Lieschke, Christian Foerch, Klaus van Leyen, Jan Hendrik Schaefer, Xiaoying Wang
Publikováno v:
Stroke
Background and Purpose— Dual antiplatelet treatment poses a risk for increased hemorrhagic transformation (HT) following intravenous thrombolysis and mechanical thrombectomy. The aim of this study was to implement a model of experimental stroke wit
Autor:
Wenlu Li, Emiri T. Mandeville, Violeta Durán-Laforet, Norito Fukuda, Zhanyang Yu, Yi Zheng, Aaron Held, Ji-Hyun Park, Takafumi Nakano, Masayoshi Tanaka, Jingfei Shi, Elga Esposito, Wanting Niu, Changhong Xing, Kazuhide Hayakawa, Ignacio Lizasoain, Klaus van Leyen, Xunming Ji, Brian J. Wainger, Maria A. Moro, Eng H. Lo
Publikováno v:
Nature communications. 13(1)
The concept of the neurovascular unit emphasizes the importance of cell-cell signaling between neural, glial, and vascular compartments. In neurogenesis, for example, brain endothelial cells play a key role by supplying trophic support to neural prog