Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Klaus Witthohn"'
Autor:
Volkmar Jacobi, Florian Schenck, Ralf Gutzmer, Klaus Witthohn, Tabea Wilhelm, Peter Mohr, Uwe Trefzer, Hans Lentzen, Katharina C. Kähler
Publikováno v:
Immunotherapy Open Access.
Aviscumine (ME-503), a recombinant lectin, enhances inflammatory cytokine (esp. IL-1β) release, activation of Langerhans cells, and T-cell responses. An extended evaluation of phase II data of the patient cohorts with/without skin reactions within t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3943d295f4451e6f63dcf432ff912ba6
https://doi.org/10.4172/2471-9552.1000135
https://doi.org/10.4172/2471-9552.1000135
Publikováno v:
Journal of Aerosol Medicine. 16:417-432
Pulmonary delivery is an attractive alternative route to deliver protein drugs that are currently delivered by injection. Inhalation therapy via nebulizers is a well accepted way for pulmonary application of proteins considering the formulation diffi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f5f4d1403086080bfcfaabddd6cca04
https://doi.org/10.1089/089426803772455677
https://doi.org/10.1089/089426803772455677
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 56:11-21
Nebulization of aqueous drug solutions is a suitable delivery system for pulmonary application of proteins because it can easily produce droplets small enough to reach the alveolar region. However, proteins are sensitive to nebulization. Therefore, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301e7fe99796de1adb2600628812fa5f
https://doi.org/10.1016/s0939-6411(03)00044-4
https://doi.org/10.1016/s0939-6411(03)00044-4
Autor:
Florian Schenck, Uwe Trefzer, Volkmar Jacobi, Klaus Witthohn, Tabea Wilhelm, Ralf Gutzmer, Katharina C. Kähler, Hans Lentzen, Peter Mohr
Publikováno v:
Journal for Immunotherapy of Cancer
Background Aviscumine, a recombinant plant protein, is an immune modulator that induces ribotoxic stress at the 28S ribosomal RNA subunit. In this way cytokine release and T-cell responses are enhanced. This phase II trial was conducted to test the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a747160458fa54451ebef92467f1c27
https://doi.org/10.1186/s40425-014-0027-z
https://doi.org/10.1186/s40425-014-0027-z
Publikováno v:
Carbohydrate Research. 327:497-504
An arabinogalactan-protein (AGP) from pressed juice of Echinacea purpurea herb was isolated from a high molecular weight fraction by precipitation with the β-glucosyl Yariv reagent, followed by gel-permeation chromatography. It revealed characterist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e2b02d8031e0447deb6e548fe99df4
https://doi.org/10.1016/s0008-6215(00)00074-4
https://doi.org/10.1016/s0008-6215(00)00074-4
Autor:
Johannes Müthing, Iris Meisen, Jörg Haier, Norbert Senninger, Martin Langer, Ulrich Neumann, Bernhard Kniep, Jasna Peter-Katalinić, Klaus Witthohn, Jadranka Milosevic
Publikováno v:
The FASEB Journal. 19:103-105
The anticancer drug rViscumin, currently under clinical development, has been shown in previous studies to be a sialic acid specific ribosome inactivating protein (RIP). Comparative binding assays with the CD75s-specific monoclonal antibodies HB6 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498b9ee0c1e0b0d7fd1b288d27f01913
https://doi.org/10.1096/fj.04-2494fje
https://doi.org/10.1096/fj.04-2494fje
Autor:
Volkmar Jacobi, Ralf Gutzmer, Tabea Wilhelm, Hans Lentzen, Peter Mohr, Florian Schenck, Uwe Trefzer, Klaus Witthohn, Katharina C. Kähler
Publikováno v:
Cancer Research. 76:CT123-CT123
Background: Aviscumine, a recombinant protein, inactivates the 28S rRNA (“ribotoxic stress”) after endocytosis and enhances inflammatory cytokine (esp. IL-1ß) release, activation of Langerhans cells and T-cell responses. Phase II data of the tot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56f9eeffa9ec62118b9304610e0f229c
https://doi.org/10.1158/1538-7445.am2016-ct123
https://doi.org/10.1158/1538-7445.am2016-ct123
Autor:
Wolf Grimminger, Klaus Witthohn
Publikováno v:
Pharmacology. 47:98-109
Toxicological studies indicate that two hydroxyanthraquinones (HAs), aloe-emodin and emodin, present as minor components in senna, might represent a genotoxic or cancerogenetic risk for man. Since aloe-emodin and emodin occur in senna in the free for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860e743071df397a77eda91f933762f9
https://doi.org/10.1159/000139848
https://doi.org/10.1159/000139848
Autor:
Heiner Fiebig, Hans Lentzen, Klaus Witthohn, Heinz Zwierzina, Steinar Aamdal, Lothar Bergmann, Patrick Schöffski
Publikováno v:
European journal of cancer (Oxford, England : 1990). 47(10)
Extracts from the European mistletoe plant Viscumalbum have been studied for decades for their direct and indirect anticancer activity. Therefore, scientists were interested in identifying the active compound (mistletoe lectin) in these extracts and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8cded0b92fb0250e0a50405607b59b6
https://pubmed.ncbi.nlm.nih.gov/21482461
https://pubmed.ncbi.nlm.nih.gov/21482461
Autor:
Katharina, Blonski, Udo, Schumacher, Iris, Burkholder, Lutz, Edler, Haleh, Nikbakht, Ina, Boeters, Anja, Peters, Christian, Kugler, Hans-Peter, Horny, Martin, Langer, Karin, Wilhelm-Ogunbiyi, Klaus, Witthohn, Eckart, Laack
Publikováno v:
Anticancer research. 25(5)
Lectins, carbohydrate proteins, bind to glycoconjugates of all mammalian cells, including cancer cells. Aberrant glycosylation, detected by lectin histochemistry, can predict outcome in some tumour entities. One such lectin is aviscumine (recombinant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3515c77329d8a3cdbe5148b1f91f57bd
https://pubmed.ncbi.nlm.nih.gov/16101142
https://pubmed.ncbi.nlm.nih.gov/16101142