Mitochondrial deficits and abnormal mitochondrial retrograde axonal transport play a role in the pathogenesis of mutant Hsp27-induced Charcot Marie Tooth Disease

Autor: Bernadett, Kalmar, Amy, Innes, Klaus, Wanisch, Alicia Koyen, Kolaszynska, Amelie, Pandraud, Gavin, Kelly, Andrey Y, Abramov, Mary M, Reilly, Giampietro, Schiavo, Linda, Greensmith

Publikováno v: Human Molecular Genetics

Mutations in the small heat shock protein Hsp27, encoded by the HSPB1 gene, have been shown to cause Charcot Marie Tooth Disease type 2 (CMT-2) or distal hereditary motor neuropathy (dHMN). Protein aggregation and axonal transport deficits have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5f0205d6180e555d7db343f90a3fbb3a
https://pubmed.ncbi.nlm.nih.gov/28595321

AMP-activated protein kinase (AMPK)-dependent and -independent pathways regulate hypoxic inhibition of transepithelial Na+ transport across human airway epithelial cells

Autor: Rafael J. Yáñez-Muñoz, RT Smolenski, Klaus Wanisch, Maksym I. Harhun, HK Patel, C D. Tan, Deborah L. Baines, Sherif G. Ahmed

Publikováno v: British Journal of Pharmacology. 167:368-382

BACKGROUND AND PURPOSE Pulmonary transepithelial Na+ transport is reduced by hypoxia, but in the airway the regulatory mechanisms remain unclear. We investigated the role of AMPK and ROS in the hypoxic regulation of apical amiloride-sensitive Na+ cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1aa4d8c47e6c460c6001a314e2d48ff6
https://doi.org/10.1111/j.1476-5381.2012.01993.x

Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus

Autor: Nabil Hajji, Banafsheh Razzaghi, Vincent T. Cunliffe, Stjepana Kovac, Michelle L. Krishnan, Johan G. Eriksson, Maxime Rotival, Klaus Wanisch, Michele Simonato, Albert J. Becker, Manuel Mattheisen, Paolo Roncon, Enrico Petretto, Doug Speed, Aleksandra Dabrowska, Marc Chadeau-Hyam, Jacques Behmoaras, Terence J. O'Brien, Federico W. Grillo, Paola L. Meza Santoscoy, Matthew C. Walker, Sarah R. Langley, Manuela Mazzuferi, Rafal Kaminski, Patrik Foerch, Marvin Johnson, Tiziana Rossetti, Susanne Schoch, Per Hoffmann, Anna Slaviero, Leonardo Bottolo, Prashant K. Srivastava, Vincenzo De Paola, Tisham De, Sven Cichon, Katharina Pernhorst, Slavé Petrovski, Pitt Niehusmann, Marec von Lehe, Kirill Shkura, Alison J. Coffey, Bénédicte Danis

Publikováno v: NATURE COMMUNICATIONS
Johnson, M R, Behmoaras, J, Bottolo, L, Krishnan, M L, Pernhorst, K, Santoscoy, P L M, Rossetti, T, Speed, D, Srivastava, P K, Chadeau-Hyam, M, Hajji, N, Dabrowska, A, Rotival, M, Razzaghi, B, Kovac, S, Wanisch, K, Grillo, F W, Slaviero, A, Langley, S R, Shkura, K, Roncon, P, De, T, Mattheisen, M, Niehusmann, P, O'Brien, T J, Petrovski, S, von Lehe, M, Hoffmann, P, Eriksson, J, Coffey, A J, Cichon, S, Walker, M, Simonato, M, Danis, B, Mazzuferi, M, Foerch, P, Schoch, S, De Paola, V, Kaminski, R M, Cunliffe, V T, Becker, A J & Petretto, E 2015, ' Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus ', Nature Communications, vol. 6, pp. 6031 . https://doi.org/10.1038/ncomms7031

Gene-regulatory network analysis is a powerful approach to elucidate the molecular processes and\ud pathways underlying complex disease. Here we employ systems genetics approaches to characterize the\ud genetic regulation of pathophysiological pathwa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8aebdabacbf3d1d0a3d5f475acb7dc3
https://doi.org/10.1038/ncomms7031

Tackling obstacles for gene therapy targeting neurons: disrupting perineural nets with hyaluronidase improves transduction

Autor: Stjepana Kovac, Klaus Wanisch, Stephanie Schorge

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e53269 (2013)
PLoS ONE

Gene therapy has been proposed for many diseases in the nervous system. In most cases for successful treatment, therapeutic vectors must be able to transduce mature neurons. However, both in vivo, and in vitro, where preliminary characterisation of v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86cff940ab6583ba463f4e28c3a88991
http://europepmc.org/articles/PMC3536767?pdf=render

Trace fear conditioning depends on NMDA receptor activation and protein synthesis within the dorsal hippocampus of mice

Autor: Klaus Wanisch, Jianrong Tang, Anna Mederer, Carsten T. Wotjak

Publikováno v: Behavioural brain research. 157(1)

Various lesion studies demonstrated that trace but not delay fear conditioning requires an intact hippocampal formation. Our present study examined the role of NMDA receptor activation and protein synthesis within the dorsal hippocampus for acquisiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac88d52597710553f51251d7efe6ef2
https://pubmed.ncbi.nlm.nih.gov/15617772