Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Klaus V Wagner"'
Autor:
Tania Carrillo-Roa, Christiana Labermaier, Peter Weber, David P Herzog, Caleb Lareau, Sara Santarelli, Klaus V Wagner, Monika Rex-Haffner, Daniela Harbich, Sebastian H Scharf, Charles B Nemeroff, Boadie W Dunlop, W Edward Craighead, Helen S Mayberg, Mathias V Schmidt, Manfred Uhr, Florian Holsboer, Inge Sillaber, Elisabeth B Binder, Marianne B Müller
Publikováno v:
PLoS Biology, Vol 15, Iss 12, p e2002690 (2017)
Response to antidepressant treatment in major depressive disorder (MDD) cannot be predicted currently, leading to uncertainty in medication selection, increasing costs, and prolonged suffering for many patients. Despite tremendous efforts in identify
Externí odkaz:
https://doaj.org/article/74a12f29eea14bc19e0b8a9d718c08d4
Autor:
Nils C Gassen, Jakob Hartmann, Jürgen Zschocke, Jens Stepan, Kathrin Hafner, Andreas Zellner, Thomas Kirmeier, Lorenz Kollmannsberger, Klaus V Wagner, Nina Dedic, Georgia Balsevich, Jan M Deussing, Stefan Kloiber, Susanne Lucae, Florian Holsboer, Matthias Eder, Manfred Uhr, Marcus Ising, Mathias V Schmidt, Theo Rein
Publikováno v:
PLoS Medicine, Vol 11, Iss 11, p e1001755 (2014)
FK506 binding protein 51 (FKBP51) is an Hsp90 co-chaperone and regulator of the glucocorticoid receptor, and consequently of stress physiology. Clinical studies suggest a genetic link between FKBP51 and antidepressant response in mood disorders; howe
Externí odkaz:
https://doaj.org/article/579581adbb6d42f9834bda6ac2728094
Autor:
Klaus V Wagner, Alexander S Häusl, Max L Pöhlmann, Jakob Hartmann, Christiana Labermaier, Marianne B Müller, Mathias V Schmidt
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85975 (2014)
Loss of motivation and learning impairments are commonly accepted core symptoms of psychiatric disorders such as depression and schizophrenia. Reward-motivated learning is dependent on the hippocampal formation but the molecular mechanisms that lead
Externí odkaz:
https://doaj.org/article/4e87c1512f5843898fde94c63b98e3fb
Autor:
Lianne Hoeijmakers, Daniela Harbich, Bianca Schmid, Paul J Lucassen, Klaus V Wagner, Mathias V Schmidt, Jakob Hartmann
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95796 (2014)
Psychiatric disorders such as depressive disorders and posttraumatic stress disorder are a major disease burden worldwide and have a higher incidence in women than in men. However, the underlying mechanism responsible for the sex-dependent difference
Externí odkaz:
https://doaj.org/article/f7de9135e3804461a963e76607a58e85
Autor:
Klaus V. Wagner, Rosa I. Hernandez, Philip M. McCabe, Armando J. Mendez, Angela Szeto, Ni Sun-Suslow
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 312:E183-E189
It has been demonstrated that the neuropeptide oxytocin (OT) attenuates oxidative stress and inflammation in macrophages. In the current study, we examined the role of inflammation on the expression of the oxytocin receptor (OXTR). We hypothesized th
Autor:
Marianne B. Müller, Jakob Hartmann, Mathias V. Schmidt, Florian Holsboer, Georgia Balsevich, Klaus V. Wagner, Andrés Uribe, Mercè Masana, Christiana Labermaier, Sara Santarelli, Carine Dournes, Alon Chen
Publikováno v:
Europe PubMed Central
Major depression is a multifactorial disease, involving both environmental and genetic risk factors. Recently, SLC6A15 - a neutral amino acid transporter mainly expressed in neurons - was proposed as a new candidate gene for major depression and stre
Autor:
Marianne B. Müller, Georg Jaschke, Christoph W. Turck, Alexander S. Häusl, Mathias V. Schmidt, D. Harbich, Gengjing Zhao, Theo Rein, Sara Santarelli, Marcel Schieven, Christiana Labermaier, Joseph G. Wettstein, Nils C. Gassen, Klaus V. Wagner, Xiao-Dong Wang, Bianca Schmid, Jakob Hartmann, Natalie Matosin, Christine Kohl, Lothar Lindemann, Christian Webhofer
Publikováno v:
Europe PubMed Central
Stress-induced psychiatric disorders, such as depression, have recently been linked to changes in glutamate transmission in the central nervous system. Glutamate signaling is mediated by a range of receptors, including metabotropic glutamate receptor
Autor:
D. Harbich, Marianne B. Müller, Boadie W. Dunlop, Monika Rex-Haffner, Mathias V. Schmidt, David P. Herzog, Klaus V. Wagner, Peter Weber, Tania Carrillo-Roa, Helen S. Mayberg, Manfred Uhr, Christiana Labermaier, Inge Sillaber, Caleb A. Lareau, Sara Santarelli, Charles B. Nemeroff, Sebastian H. Scharf, W. Edward Craighead, Florian Holsboer, Elisabeth B. Binder
Publikováno v:
PLoS Biology
PLOS BIOLOGY
PLoS Biology, Vol 15, Iss 12, p e2002690 (2017)
PLoS biology, 15(12):e2002690
PLOS BIOLOGY
PLoS Biology, Vol 15, Iss 12, p e2002690 (2017)
PLoS biology, 15(12):e2002690
Response to antidepressant treatment in major depressive disorder (MDD) cannot be predicted currently, leading to uncertainty in medication selection, increasing costs, and prolonged suffering for many patients. Despite tremendous efforts in identify
Autor:
Clara Engelhardt, Max L. Pöhlmann, Lianne Hoeijmakers, Marian Joëls, Sören Westerholz, Alexander S. Häusl, Alon Chen, Jan M. Deussing, Klaus V. Wagner, Mathias V. Schmidt, Henk Karst, Christiana Labermaier, Nina Dedic, M Kertokarijo, Jakob Hartmann
Publikováno v:
Molecular Psychiatry, 22, 466–475. Nature Publishing Group
Molecular Psychiatry, 22(3). Nature Publishing Group
Molecular Psychiatry, 22(3). Nature Publishing Group
Anxiety disorders constitute a major disease and social burden worldwide; however, many questions concerning the underlying molecular mechanisms still remain open. Besides the involvement of the major excitatory (glutamate) and inhibitory (gamma amin
Autor:
Marianne B. Müller, Felix Hausch, Elisabeth B. Binder, Florian Holsboer, Rainer Landgraf, Julia Brenndörfer, L. Czibere, Peter Weber, Mathias V. Schmidt, Carina Quast, Christiana Labermaier, Andre Altmann, Jakob Hartmann, Sebastian H. Scharf, Christian Devigny, Janine Arloth, Manfred Uhr, Klaus V. Wagner, Christine Kohl, Regina Widner-Andrä, Kenneth A. Jones
Publikováno v:
Endocrinology. 155:2500-2510
Chronic stress is a risk factor for psychiatric disorders but does not necessarily lead to uniform long-term effects on mental health, suggesting modulating factors such as genetic predispositions. Here we address the question whether natural genetic