Zobrazeno 1 - 10
of 990
pro vyhledávání: '"Klaus V, Toyka"'
Publikováno v:
Neurological Research and Practice, Vol 5, Iss 1, Pp 1-11 (2023)
Abstract Background In sepsis-associated critical illness neuromyopathy (CIPNM) serial electrical stimulation of motor nerves induces a short-lived temporary recovery of compound muscle action potentials (CMAPs) termed facilitation phenomenon (FP). T
Externí odkaz:
https://doaj.org/article/8b88555ef71c49c5b2b521c22ac272c0
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 14, Iss 1, Pp 1-5 (2022)
Abstract Background A treatment-induced drop in HbA1c has been suggested to be a risk factor for TIND. Methods From 60 included patients with severe diabetes mellitus (HbA1c over 8.5) only 21 patients adhered to the study protocol over 1 year with a
Externí odkaz:
https://doaj.org/article/ab59769704974b2486b5ea37b3bd8d94
Autor:
Anna Henzi, Assunta Senatore, Asvin K K Lakkaraju, Claudia Scheckel, Jonas Mühle, Regina Reimann, Silvia Sorce, Gebhard Schertler, Klaus V Toyka, Adriano Aguzzi
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0242137 (2020)
The adhesion G-protein coupled receptor Adgrg6 (formerly Gpr126) is instrumental in the development, maintenance and repair of peripheral nervous system myelin. The prion protein (PrP) is a potent activator of Adgrg6 and could be used as a potential
Externí odkaz:
https://doaj.org/article/95263374d6fd48b09546525b07214cbc
Publikováno v:
Clinical Neurophysiology. 142:244-253
Critical Illness Neuromyopathy (CIPNM) is a complication in sepsis patients with still enigmatic disease mechanisms. We investigated a novel electrical stimulation method to better define neuromuscular dysfunction in patients with CIPNM.We studied 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9714e36be346d3926192ee575b74311
https://doi.org/10.1016/j.clinph.2022.07.509
https://doi.org/10.1016/j.clinph.2022.07.509
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10835 (2021)
The pathogenesis of diabetic neuropathy is complex, and various pathogenic pathways have been proposed. A better understanding of the pathophysiology is warranted for developing novel therapeutic strategies. Here, we summarize recent evidence from ex
Externí odkaz:
https://doaj.org/article/bd868c6f2b29430e96da1bb8e9d4df06
Autor:
Daniel Gerber, Monica Ghidinelli, Elisa Tinelli, Christian Somandin, Joanne Gerber, Jorge A Pereira, Andrea Ommer, Gianluca Figlia, Michaela Miehe, Lukas G Nägeli, Vanessa Suter, Valentina Tadini, Páris NM Sidiropoulos, Carsten Wessig, Klaus V Toyka, Ueli Suter
Publikováno v:
eLife, Vol 8 (2019)
Myelination requires extensive plasma membrane rearrangements, implying that molecules controlling membrane dynamics play prominent roles. The large GTPase dynamin 2 (DNM2) is a well-known regulator of membrane remodeling, membrane fission, and vesic
Externí odkaz:
https://doaj.org/article/af9ab6773f8547549f402cbb9cb83ae6
Autor:
Petra Baum, Severin Koj, Nora Klöting, Matthias Blüher, Joseph Classen, Sabine Paeschke, Martin Gericke, Klaus V. Toyka, Marcin Nowicki, Joanna Kosacka
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 1571 (2021)
Treatment-induced neuropathy in diabetes (TIND) is defined by the occurrence of an acute neuropathy within 8 weeks of an abrupt decrease in glycated hemoglobin-A1c (HbA1c). The underlying pathogenic mechanisms are still incompletely understood with o
Externí odkaz:
https://doaj.org/article/56edc0d1849b4eeba3988947641b9add
Autor:
Benedikt Grünewald, Maren D Lange, Christian Werner, Aet O'Leary, Andreas Weishaupt, Sandy Popp, David A Pearce, Heinz Wiendl, Andreas Reif, Hans C Pape, Klaus V Toyka, Claudia Sommer, Christian Geis
Publikováno v:
eLife, Vol 6 (2017)
Juvenile neuronal ceroid lipofuscinosis (JNCL or Batten disease) caused by mutations in the CLN3 gene is the most prevalent inherited neurodegenerative disease in childhood resulting in widespread central nervous system dysfunction and premature deat
Externí odkaz:
https://doaj.org/article/73ff6f4c6ad249a0ae51af6071b9bb4c
Autor:
Christiane Schneider-Gold, Marco Krenzer, Erdmute Klinker, Behrouz Mansouri-Thalegani, Wolfgang Müllges, Klaus V. Toyka, Ralf Gold
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 9 (2016)
Objectives: The goal of this study was to analyze safety and assess the efficacy of standard plasma exchange (PE) compared with immunoadsorption (IA) alone, or an alternating combination of both in deteriorating myasthenia gravis (MG). Methods: A tot
Externí odkaz:
https://doaj.org/article/d259dae82bdf4fe2978e5820d8a26cf2
Autor:
Brigitte Buchwald, Gang Zhang, Angela K. Vogt-Eisele, Weiyi Zhang, Raheleh Ahangari, John W. Griffin, Hanns Hatt, Klaus V. Toyka, Kazim A. Sheikh
Publikováno v:
Neurobiology of Disease, Vol 28, Iss 1, Pp 113-121 (2007)
Acute motor axonal neuropathy (AMAN) variant of Guillain–Barré syndrome is often associated with IgG anti-GM1 and -GD1a antibodies. The pathophysiological basis of antibody-mediated selective motor nerve dysfunction remains unclear. We investigate
Externí odkaz:
https://doaj.org/article/685b40d018374bc28ade023299c2a43e