Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Klaus Unfried"'
Autor:
Torben Stermann, Thach Nguyen, Burkhard Stahlmecke, Ana Maria Todea, Selina Woeste, Inken Hacheney, Jean Krutmann, Klaus Unfried, Roel P. F. Schins, Andrea Rossi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Cystic fibrosis is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) that can lead to terminal respiratory failure. Ultrafine carbonaceous particles, which are ubiquitous in
Externí odkaz:
https://doaj.org/article/d7c64df7cb9a4ae78e391e5e35ce98aa
Autor:
Linda Elberskirch, Kunigunde Binder, Norbert Riefler, Adriana Sofranko, Julia Liebing, Christian Bonatto Minella, Lutz Mädler, Matthias Razum, Christoph van Thriel, Klaus Unfried, Roel P. F. Schins, Annette Kraegeloh
Publikováno v:
Particle and Fibre Toxicology, Vol 19, Iss 1, Pp 1-19 (2022)
Abstract Background Assessing the safety of engineered nanomaterials (ENMs) is an interdisciplinary and complex process producing huge amounts of information and data. To make such data and metadata reusable for researchers, manufacturers, and regula
Externí odkaz:
https://doaj.org/article/26de6d8b78c8470aaceb5e6eefe5a8a9
Autor:
Linda Elberskirch, Adriana Sofranko, Julia Liebing, Norbert Riefler, Kunigunde Binder, Christian Bonatto Minella, Matthias Razum, Lutz Mädler, Klaus Unfried, Roel P. F. Schins, Annette Kraegeloh, Christoph van Thriel
Publikováno v:
Nanomaterials, Vol 12, Iss 7, p 1053 (2022)
It has been widely recognized that nanosafety studies are limited in reproducibility, caused by missing or inadequate information and data gaps. Reliable and comprehensive studies should be performed supported by standards or guidelines, which need t
Externí odkaz:
https://doaj.org/article/8dd9b552a0d54a179664af8cfbaa422d
Autor:
Niloofar Ale-Agha, Christine Goy, Philipp Jakobs, Ioakim Spyridopoulos, Stefanie Gonnissen, Nadine Dyballa-Rukes, Karin Aufenvenne, Florian von Ameln, Mark Zurek, Tim Spannbrucker, Olaf Eckermann, Sascha Jakob, Simone Gorressen, Marcel Abrams, Maria Grandoch, Jens W Fischer, Karl Köhrer, René Deenen, Klaus Unfried, Joachim Altschmied, Judith Haendeler
Publikováno v:
PLoS Biology, Vol 16, Iss 6, p e2004408 (2018)
We show that the cyclin-dependent kinase inhibitor 1B (CDKN1B)/p27, previously known as a cell cycle inhibitor, is also localized within mitochondria. The migratory capacity of endothelial cells, which need intact mitochondria, is completely dependen
Externí odkaz:
https://doaj.org/article/b537d1dd586d462a80e9c8203d121f2e
Autor:
Daniel Stöckmann, Tim Spannbrucker, Niloofar Ale-Agha, Philipp Jakobs, Christine Goy, Nadine Dyballa-Rukes, Tamara Hornstein, Alexander Kümper, Annette Kraegeloh, Judith Haendeler, Klaus Unfried
Publikováno v:
Nanomaterials, Vol 8, Iss 4, p 267 (2018)
The epidermal growth factor receptor (EGFR) is an abundant membrane protein, which is essential for regulating many cellular processes including cell proliferation. In our earlier studies, we observed an activation of the EGFR and subsequent signalin
Externí odkaz:
https://doaj.org/article/2086d9a1f9384f04bb96313a9fbec805
Autor:
Andrea Autengruber, Ulrich Sydlik, Matthias Kroker, Tamara Hornstein, Niloofar Ale-Agha, Daniel Stöckmann, Andreas Bilstein, Catrin Albrecht, Adnana Paunel-Görgülü, Christoph V Suschek, Jean Krutmann, Klaus Unfried
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111485 (2014)
The inhalation of combustion-derived nanoparticles leads to adverse health effects in the airways. In this context the induction of membrane-coupled signalling is considered as causative for changes in tissue homeostasis and pro-inflammatory reaction
Externí odkaz:
https://doaj.org/article/63c96b06ae024f998aac3624886e993f
Autor:
Sara Kress, Anna Kilanowski, Claudia Wigmann, Qi Zhao, Tianyu Zhao, Michael J. Abramson, Monika Gappa, Marie Standl, Klaus Unfried, Tamara Schikowski
Publikováno v:
Science of The Total Environment. 841:156655
The fractional exhaled nitric oxide (FeNO) concentration in the exhaled breath is a biomarker for eosinophilic airway inflammation. We explored the interplay between chronic air pollution exposure and polygenic susceptibility to airway inflammation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a59fd7e1d9518faaf57493fb95a444de
https://doi.org/10.1016/j.scitotenv.2022.156655
https://doi.org/10.1016/j.scitotenv.2022.156655
Autor:
Christine Goy, Niloofar Ale-Agha, Tim Spannbrucker, Judith Haendeler, Joachim Altschmied, Klaus Unfried, Philipp Jakobs, Nadine Dyballa-Rukes, Kirsten Jander
Publikováno v:
Experimental Gerontology. 117:106-112
Inhalation of combustion-derived particles is associated with the development of age-related diseases like chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. In both diseases senescence of lung epithelial cells has been observed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0999051c49cb5f7b420810b54263d662
https://doi.org/10.1016/j.exger.2018.11.017
https://doi.org/10.1016/j.exger.2018.11.017
Autor:
Kija Shah-Hosseini, Andreas Bilstein, Van-Anh Dao, Ralph Mösges, Binh-Hai Tran, Klaus Unfried
Publikováno v:
BioMed Research International, Vol 2019 (2019)
BioMed Research International
BioMed Research International
Purpose. This study investigated an inhalation solution containing ectoine, a bacterial-derived extremolyte, for the treatment of acute bronchitis and acute respiratory infections in comparison with saline inhalation solution. Methods. This prospecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349598d8774a9512fa90e2f52f7079d3
https://doi.org/10.1155/2019/7945091
https://doi.org/10.1155/2019/7945091
Autor:
Joachim Altschmied, André Heinen, Petra Kleinbongard, Niloofar Ale-Agha, Sabine Metzger, Jan Greulich, Philipp Jakobs, Judith Haendeler, Gerd Heusch, Julia Rosen, Fedor Brack, Olaf Eckermann, Mark Zurek, Nilgün Gedik, Christine Goy, Markus Kamler, Matthias Thielmann, Axel Gödecke, Nadine Dyballa-Rukes, Florian von Ameln, Klaus Unfried, Maria Grandoch
Background: The catalytic subunit of telomerase, telomerase reverse transcriptase (TERT), has protective functions in the cardiovascular system. TERT is not only present in the nucleus but also in mitochondria. However, it is unclear whether nuclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056e10a0224ded22a6085371d4ecd9dc
https://www.ncbi.nlm.nih.gov/pubmed/34672678
https://www.ncbi.nlm.nih.gov/pubmed/34672678
