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pro vyhledávání: '"Klaus Ulrich Dr Weithmann"'
Autor:
Hans Matter, Herman Schreuder, Haase Burkhard, Manfred Schudok, Günter Dr. Billen, Denis Barbier, Werner Thorwart, Klaus Ulrich Dr Weithmann, Bernhard Neises, Volker Brachvogel, Petra Lönze, Wilfried Schwab
Publikováno v:
Journal of Medicinal Chemistry. 42:1908-1920
A set of 90 novel 2-(arylsulfonyl)-1,2,3, 4-tetrahydroisoquinoline-3-carboxylates and -hydroxamates as inhibitors of the matrix metalloproteinase human neutrophil collagenase (MMP-8) was designed, synthesized, and investigated by 3D-QSAR techniques (