Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Klaus Strein"'
Autor:
Anja Seckinger, Sara Majocchi, Valéry Moine, Lise Nouveau, Hoang Ngoc, Bruno Daubeuf, Ulla Ravn, Nicolas Pleche, Sebastien Calloud, Lucile Broyer, Laura Cons, Adeline Lesnier, Laurence Chatel, Anne Papaioannou, Susana Salgado-Pires, Sebastian Krämer, Ines Gockel, Florian Lordick, Krzysztof Masternak, Yves Poitevin, Giovanni Magistrelli, Pauline Malinge, Limin Shang, Sonja Kallendrusch, Klaus Strein, Dirk Hose
Publikováno v:
Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-23 (2023)
Abstract Background T-cell retargeting to eliminate CEACAM5-expressing cancer cells via CEACAM5xCD3 bispecific antibodies (BsAbs) showed limited clinical activity so far, mostly due to insufficient T-cell activation, dose-limiting toxicities, and for
Externí odkaz:
https://doaj.org/article/30b29a2c343143119fd06970474edb47
Autor:
Anja Seckinger, Vanessa Buatois, Valéry Moine, Lise Nouveau, Bruno Daubeuf, Sara Majocchi, Ulla Ravn, Nicolas Bosson, Krzysztof Masternak, Yves Poitevin, Giovanni Magistrelli, Pauline Malinge, Limin Shang, Nicolas Fischer, Klaus Strein, Walter Ferlin, Dirk Hose
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77df5112aad22f46160730295ee47ea1
https://doi.org/10.1136/jitc-2022-sitc2022.0853
https://doi.org/10.1136/jitc-2022-sitc2022.0853
Autor:
Anja Seckinger, Lise Nouveau, Sara Majocchi, Valéry Moine, Vanessa Buatois, Bruno Daubeuf, Franck Gueneau, Ulla Ravn, Krzysztof Masternak, Yves Poitevin, Emeline Rousset, Giovanni Magistrelli, Pauline Malinge, Limin Shang, Nicolas Fischer, Klaus Strein, Walter Ferlin, Dirk Hose
Publikováno v:
Cancer Research. 83:5100-5100
Background: The CEAxCD3 bispecific antibody (bsAb) NILK-2301 couples CEA (CEACAM5) on cancer cells and CD3 on T-cells inducing T-cell activation (signal 1) and tumor cell killing (TDCC). T-cell activation can be boosted by CEA-targeted CD28-costimula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1760c99559987da8f99a8455134043ac
https://doi.org/10.1158/1538-7445.am2023-5100
https://doi.org/10.1158/1538-7445.am2023-5100
Autor:
Ramona Murr, Elisabetta Ada Cavalcanti-Adam, Juana Merino, Reto Gianotti, Aintzane Zabaleta, Marina Bacac, Anthony D. Ho, Martina Emde, Jose Antonio Delgado, Samuel Moser, Felipe Prosper, Lydia Jasmin Harnisch, Anna Luise Grab, Jens Hillengass, Melanie Latzko, Klaus Strein, Ralf Hosse, Tanja Fauti, Jesús F. San Miguel, Remo Lüoend, Brigitte Neuber, Bruno Paiva, Pablo Umana, Minh Diem Vu, Christian Klein, Camille Delon, Anja Seckinger, Susanne Lipp, Michael Hundemer, Laura Moreno, Dirk Hose
Publikováno v:
Cancer Cell
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
We identified B cell maturation antigen (BCMA) as a potential therapeutic target in 778 newly diagnosed and relapsed myeloma patients. We constructed an IgG-based BCMA-T cell bispecific antibody (EM801) and showed that it increased CD3+ T cell/myelom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3e8fb7b6e31ecaf1ebc31b68dfbe19
https://biblio.vub.ac.be/vubir/target-expression-generation-preclinical-activity-and-pharmacokinetics-of-the-bcmat-cell-bispecific-antibody-em801-for-multiple-myeloma-treatment(3de0c7eb-7a6c-49c6-ab48-956cf6c1a52a).html
https://biblio.vub.ac.be/vubir/target-expression-generation-preclinical-activity-and-pharmacokinetics-of-the-bcmat-cell-bispecific-antibody-em801-for-multiple-myeloma-treatment(3de0c7eb-7a6c-49c6-ab48-956cf6c1a52a).html
Autor:
Erika Möllendorff, Gisbert Sponer, Klaus Strein, Wolfgang Bartsch, Bernd Müller-Beckmann, Günter Neugebauer, Harald Czerwek, Gerd Bode, Erhard Schnurr
Publikováno v:
Cardiovascular Drug Reviews. 5:135-153
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0104fae0168262128bc4b5d63b0e191f
https://doi.org/10.1111/j.1527-3466.1987.tb00506.x
https://doi.org/10.1111/j.1527-3466.1987.tb00506.x
Autor:
Anja Seckinger, Felipe Prosper, Brigitte Neuber, Klaus Strein, Jose Antonio Delgado, Bruno Paiva, Jesús F. San Miguel, Juana Merino, Anna Luise Grab, Minh Diem Vu, Susanne Lipp, Dirk Hose, Michael Hundemer, Laura Moreno
Publikováno v:
Blood. 126:117-117
Background. T-cell bispecific antibodies (TCBs) simultaneously binding CD3 on T-cells and individual tumor antigens, activate T-cells and destroy tumor antigen carrying cells. B-cell maturation antigen (BCMA), a surface antigen reported to be express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c0bf85069ed49ef2aaee5791dd118bd
https://doi.org/10.1182/blood.v126.23.117.117
https://doi.org/10.1182/blood.v126.23.117.117
Autor:
Pablo Umana, Ralf Hosse, Remo Lüoend, Melanie Latzko, Klaus Strein, Anne Freimoser-Grundschober, Reto Gianotti, Jörg Zielonka, Ramona Murr, Ekkehard Mössner, Christian Klein, Tea Rodriguez Diaz, Chloé Friang, Marina Bacac, Lydia Jasmin Duerner, Oliver Ast, Tanja Fauti, Camille Delon, Samuel Moser, Minh Diem Vu, Peter Bruenker, Erwin van Puijenbroek, Tina Weinzierl
Publikováno v:
Blood. 126:2998-2998
Background & Aim: T-cell bispecific antibodies (TCBs) binding to a target on tumor cells and CD3 on T cells induce potent T-cell mediated killing of cells carrying the target. In contrast to targets like e.g. CD38 or CD138, B-cell maturation antigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83d0c28c975fbab84dd30f070e874188
https://doi.org/10.1182/blood.v126.23.2998.2998
https://doi.org/10.1182/blood.v126.23.2998.2998
Publikováno v:
Journal of the American College of Cardiology. 19(2):433-440
The thrombolytic and systemic effects of BM 06.022 were evaluated and compared with those of alteplase, anistreplase, streptokinase and urokinase in a canine model of coronary artery thrombosis. BM 06.022 consists of the kringle-2 and protease domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5249506a0fe99ab3e5058f711597c4
Publikováno v:
Archiv der Pharmazie. 325:727-732
Von dem gefaswirksamen Salpetersaureester trans-2-Amino-2-methyl-N-(4-nitroxycyclohexyl)-propionsaureamid (BM 12.1179) (1) sind, ausgehend von der sterisch gehinderten α-Aminoisobuttersaure (2), die 13C- und 14C-markierten Verbindungen synthetisiert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a984480835f5ebf3c8c1c30632a983be
https://doi.org/10.1002/ardp.19923251109
https://doi.org/10.1002/ardp.19923251109
Autor:
Stephan Fischer, Klaus Strein, Ulrich Kohnert, Ulrich Opitz, Anne Stern, Gisbert Sponer, Rainer Rudolph, Ulrich Martin
Publikováno v:
Thrombosis and haemostasis. 65(5)
SummaryThe recombinant plasminogen activator BM 06.022 consists of the kringle 2 and the protease domains of human t-PA and is unglycosylated because of the expression in Escherichia coli The thrombolytic and pharmacokinetic properties as well as the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3966aa3a17cd29bf3f57ed9d3343a9
https://pubmed.ncbi.nlm.nih.gov/1908140
https://pubmed.ncbi.nlm.nih.gov/1908140