Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Klaus Seedorf"'
Autor:
Klaus Seedorf, Csaba Weber, Cedric Vinson, Sylvie Berger, Laurent-Michel Vuillard, Arpad Kiss, Stephanie Creusot, Olivier Broux, Anne Geant, Catherine Ilic, Karine Lemaitre, Johann Richard, Adel Hammoutene, Julien Mahieux, Virginie Martiny, Didier Durand, Fabien Melchiore, Miklos Nyerges, Valerie Paradis, Nicolas Provost, Valérie Duvivier, Philippe Delerive
Publikováno v:
JHEP Reports, Vol 5, Iss 4, Pp 100651- (2023)
Background & Aims: Oxidative stress is recognized as a major driver of non-alcoholic steatohepatitis (NASH) progression. The transcription factor NRF2 and its negative regulator KEAP1 are master regulators of redox, metabolic and protein homeostasis,
Externí odkaz:
https://doaj.org/article/7430d7109ccc497e953400e0d8e23dfb
Autor:
Klaus Seedorf, Pascal Ferré
Publikováno v:
Current Opinion in Pharmacology. 9:733-736
Publikováno v:
Biochemical Journal. 351:613-619
Phospholipase D (PLD)1 is quiescent in vitro and in vivo until stimulated by classical protein kinase C (PKC) isoforms, ADP-ribosylation factor or Rho family members. By contrast, PLD2 has high basal activity, and the mechanisms involved in agonist-i
Autor:
Klaus Seedorf, Reinhard Wetzker, Steffen Gross, Antje Adomeit, Claus Liebmann, Angela Graness
Publikováno v:
Molecular and Cellular Biology. 19:5289-5297
The extracellular signal-regulated kinases ERK1 and ERK2 belong to the mitogen-activated protein kinase (MAPK) family and may be regulated by both receptor tyrosine kinases (RTKs) and G-protein-coupled receptors (GPCRs). Their activation via RTKs is
Autor:
Tencho Tenev, Elke Nyakatura, Lene Nielsen, Jasminka Godovac-Zimmermann, Heike Keilhack, Frank-D. Böhmer, Klaus Seedorf
Publikováno v:
Journal of Biological Chemistry. 273:24839-24846
The protein-tyrosine phosphatase SHP-1 binds to and dephosphorylates the epidermal growth factor receptor (EGFR), and both SH2 domains of SHP-1 are important for this interaction (Tenev, T., Keilhack, H., Tomic, S., Stoyanov, B., Stein-Gerlach, M., L
Autor:
Thomas Mandrup-Poulsen, Michael S.-S. Su, Leland Shapiro, Allan E. Karlsen, Lone F. Juhl, Claus M. Larsen, Charles A. Dinarello, Henrik U. Andersen, Karin Wadt, Klaus Seedorf
Publikováno v:
Journal of Biological Chemistry. 273:15294-15300
Interleukin-1beta (IL-1beta) is cytotoxic to rat pancreatic beta-cells by inhibiting glucose oxidation, causing DNA damage and inducing apoptosis. Nitric oxide (NO) is a necessary but not sufficient mediator of these effects. IL-1beta induced kinase
Autor:
Klaus Seedorf
Publikováno v:
Metabolism. 44:24-32
Growth factors are involved in a variety of cellular responses such as growth, differentiation, migration, metabolism, and transformation. Binding of the growth factor to its corresponding cell surface receptor results in activation of the receptor's
Autor:
Ignacio Rubio, J. Justin Hsuan, Peter Gierschik, Michael Loubtchenkov, Theodor Hanck, Ritu Dhand, Bernd Nürnberg, Klaus Seedorf, Borislav Stoyanov, Michael D. Waterfield, Reinhard Wetzker, Stefka Stoyanova, Stefano Volinia, Daria Malek, Bart Vanhaesebroeck
Publikováno v:
Science. 269:690-693
Phosphoinositide-3 kinase activity is implicated in diverse cellular responses triggered by mammalian cell surface receptors and in the regulation of protein sorting in yeast. Receptors with intrinsic and associated tyrosine kinase activity recruit h
Autor:
Günter Kostka, R Daly, Richard L. Lammers, Axel Ullrich, Joseph Schlessinger, Klaus Seedorf, P Bashkin, A M van der Bliek, W H Burgess
Publikováno v:
Journal of Biological Chemistry. 269:16009-16014
Src homology 3 (SH3) domains are found in a variety of proteins that are involved in signal transduction or represent components of the cytoskeleton. These domains are thought to serve as modules that mediate specific protein-protein interactions tha
Publikováno v:
Biochemical and biophysical research communications. 407(2)
Activation of the classical IκB kinases (IKKα and IKKβ) was previously shown to contribute to obesity-induced inflammation and insulin resistance. Using knockout mice, we investigated whether the related isoform IKKe plays a similar metabolic role