Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression

Autor: Nico van Rooijen, Milan Theurl, Guenter Weiss, Kathrin Hochegger, Klaus Schuemann, V. Nathan Subramaniam, Peter Obrist, Igor Theurl

Publikováno v: Journal of Molecular Medicine, 86(7), 825-835. Springer Verlag
Theurl, M, Theurl, I, Hochegger, K, Obrist, P, Subramaniam, N, van Rooijen, N, Schuemann, K & Weiss, G 2008, ' Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression ', Journal of Molecular Medicine, vol. 86, no. 7, pp. 825-835 . https://doi.org/10.1007/s00109-008-0346-y

Hepcidin, a small cationic liver derived peptide, is a master regulator of body iron homeostasis. Cytokines and iron availability have so far been identified as regulators of hepcidin expression. Herein, we investigated the functional role of Kupffer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf837f5a6f687fe81b726f17a0c6e69
https://doi.org/10.1007/s00109-008-0346-y

Depletion of Dietary Iron Alters the Gut Microbiome and Prevents Crohn's Disease-Like Ileitis

Autor: Jens Walter, Klaus Schuemann, Jung-Su Chang, Tanja Werner, Dirk Haller, Thomas Clavel, Inés Martínez, Sigrid Kisling, Stefan J. Wagner

Publikováno v: Zeitschrift für Gastroenterologie. 49

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60decbe09f2147ed7f91d1343f622072
https://doi.org/10.1055/s-0031-1304762

Depletion of luminal iron alters the gut microbiota and prevents Crohn's disease-like ileitis

Autor: Stefan J. Wagner, Thomas Clavel, Tanja Werner, Sigrid Kisling, Klaus Schuemann, Dirk Haller, Jens Walter, Jung-Su Chang, Inés Martínez

Publikováno v: Gut. 60(3)

Background Iron replacement therapy is a common treatment in patients with anaemia and Crohn9s disease, but oral iron supplements are less tolerated. The pathogenesis of Crohn9s disease is attributed to intestinal bacteria and environmental factors t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec551f3297b54d6a862735ee662bbc8
https://pubmed.ncbi.nlm.nih.gov/21561878

Oral‐iron‐associated depletion of the fecal antioxidant capacity state is improved by concurrent dietary antioxidants

Autor: Monica N Orozco, James K. Friel, Noel W. Solomons, Klaus Schuemann

Publikováno v: The FASEB Journal. 22

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a9b8691c763a75023da71ac710a20b5
https://doi.org/10.1096/fasebj.22.1_supplement.445.1

M1757 Impact of Luminal and Systemic Iron on the Development of Chronic Ileitis Targeting the Gut Microbial Composition and Stress Response in Intestinal Epithelial Cells

Autor: Sigrid Kisling, Dirk Haller, Tanja Werner, Inés Martínez, Stefan J. Wagner, Jung-Su Chang, Jens Walter, Klaus Schuemann

Publikováno v: Gastroenterology. 138:S-413

activity, but also MMP-9 activity in DSS-treated mice. Chymase activity was significantly lower in the NK3201-treated group than in the placebo-treated group. MMP-9 level was also significantly lower in the NK3201-treated group than in the placebo-tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c17e3d792d66b0b548d8c5c23c9876b2
https://doi.org/10.1016/s0016-5085(10)61900-2