Zobrazeno 1 - 10
of 557
pro vyhledávání: '"Klaus Rajewsky"'
Publikováno v:
Bio-Protocol, Vol 14, Iss 20 (2024)
The adoptive transfer of autologous, long-lived, gene-repaired T cells is a promising way to treat inherited T-cell immunodeficiencies. However, adoptive T-cell therapies require a large number of T cells to be manipulated and infused back into the p
Externí odkaz:
https://doaj.org/article/42409b6dbc64483db8204596e1ca5750
Autor:
Nikolai Schleussner, Pierre Cauchy, Vedran Franke, Maciej Giefing, Oriol Fornes, Naveen Vankadari, Salam A. Assi, Mariantonia Costanza, Marc A. Weniger, Altuna Akalin, Ioannis Anagnostopoulos, Thomas Bukur, Marco G. Casarotto, Frederik Damm, Oliver Daumke, Benjamin Edginton-White, J. Christof M. Gebhardt, Michael Grau, Stephan Grunwald, Martin-Leo Hansmann, Sylvia Hartmann, Lionel Huber, Eva Kärgel, Simone Lusatis, Daniel Noerenberg, Nadine Obier, Ulrich Pannicke, Anja Fischer, Anja Reisser, Andreas Rosenwald, Klaus Schwarz, Srinivasan Sundararaj, Andre Weilemann, Wiebke Winkler, Wendan Xu, Georg Lenz, Klaus Rajewsky, Wyeth W. Wasserman, Peter N. Cockerill, Claus Scheidereit, Reiner Siebert, Ralf Küppers, Rudolf Grosschedl, Martin Janz, Constanze Bonifer, Stephan Mathas
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Disease-causing mutations in genes encoding transcription factors (TFs) can affect TF interactions with their cognate DNA-binding motifs. Whether and how TF mutations impact upon the binding to TF composite elements (CE) and the interaction
Externí odkaz:
https://doaj.org/article/89617bbfc2d9437a8c22b2474e5ec08c
Autor:
Jingwei Zhang, Thomas Sommermann, Xun Li, Lutz Gieselmann, Kathrin de la Rosa, Maria Stecklum, Florian Klein, Christine Kocks, Klaus Rajewsky
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionEpstein-Barr virus (EBV) infection in humans is associated with a wide range of diseases including malignancies of different origins, most prominently B cells. Several EBV latent genes are thought to act together in B cell immortalization
Externí odkaz:
https://doaj.org/article/8852a3cd953b41d59483648d9256e588
Autor:
Tuan Anh Le, Van Trung Chu, Andreia C. Lino, Eva Schrezenmeier, Christopher Kressler, Dania Hamo, Klaus Rajewsky, Thomas Dörner, Van Duc Dang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 30, Iss , Pp 621-632 (2022)
Human B lymphocytes are attractive targets for immunotherapies in autoantibody-mediated diseases. Gene editing technologies could provide a powerful tool to determine gene regulatory networks regulating B cell differentiation into plasma cells, and i
Externí odkaz:
https://doaj.org/article/174f4a9188c14eeabc505f36d39a9a14
Publikováno v:
Bio-Protocol, Vol 13, Iss 8 (2023)
The CRISPR/Cas9 system is a powerful tool for gene repair that holds great potential for gene therapy to cure monogenic diseases. Despite intensive improvement, the safety of this system remains a major clinical concern. In contrast to Cas9 nuclease,
Externí odkaz:
https://doaj.org/article/f12665057d33439795d2811856568a68
Autor:
Ermeng Xiong, Oliver Popp, Claudia Salomon, Philipp Mertins, Christine Kocks, Klaus Rajewsky, Van Trung Chu
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
IntroductionThe differentiation of B cells into antibody-secreting plasma cells depends on cell division-coupled, epigenetic and other cellular processes that are incompletely understood.MethodsWe have developed a CRISPR/Cas9-based screen that models
Externí odkaz:
https://doaj.org/article/e666a713e63840f1879d9ae3e6e78d24
Autor:
Magdalena Hagen, Tirtha Chakraborty, William J. Olson, Martin Heitz, Natascha Hermann-Kleiter, Janine Kimpel, Brigitte Jenewein, Johanna Pertoll, Verena Labi, Klaus Rajewsky, Emmanuel Derudder
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
B lymphocyte development proceeds through a well-ordered sequence of steps, leading to the formation of a sizeable mature B population recognizing a diversity of antigens. These latter cells are ultimately responsible for the production of antibodies
Externí odkaz:
https://doaj.org/article/571cedaed8154a859d7316d01c67d07c
Autor:
Vera Kristin Schmid, Ahmad Khadour, Nabil Ahmed, Carolin Brandl, Lars Nitschke, Klaus Rajewsky, Hassan Jumaa, Elias Hobeika
Publikováno v:
Haematologica, Vol 107, Iss 8 (2022)
Chronic lymphocytic leukemia (CLL) is a frequent lymphoproliferative disorder of B cells. Although inhibitors targeting signal proteins involved in B-cell antigen receptor (BCR) signaling constitute an important part of the current therapeutic protoc
Externí odkaz:
https://doaj.org/article/e5c0a11a07cd48aebe8e319f62fac762
Autor:
Jason B. Wong, Susannah L. Hewitt, Lynn M. Heltemes-Harris, Malay Mandal, Kristen Johnson, Klaus Rajewsky, Sergei B. Koralov, Marcus R. Clark, Michael A. Farrar, Jane A. Skok
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
B-1a B cells are innate-like cells with biased reactivity to bacteria and self-antigens. Here the authors show that reduced interleukin-7 in developing fetal liver-derived pro-B cells induces premature immunoglobulin κ rearrangement, alleviating the
Externí odkaz:
https://doaj.org/article/187b8150da99438da49e30693e5b9441
Autor:
Kristin Schmidt, Ulrike Sack, Robin Graf, Wiebke Winkler, Oliver Popp, Philipp Mertins, Thomas Sommermann, Christine Kocks, Klaus Rajewsky
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
A highly recurrent somatic L265P mutation in the TIR domain of the signaling adapter MYD88 constitutively activates NF-κB. It occurs in nearly all human patients with Waldenström’s macroglobulinemia (WM), a B cell malignancy caused by IgM-express
Externí odkaz:
https://doaj.org/article/30fde32fd57e4732ba0071b3311da507