Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Klaus Pflügler"'
Autor:
Sebastian Schmidt, Malte D. Luecken, Dietrich Trümbach, Sina Hembach, Kristina M. Niedermeier, Nicole Wenck, Klaus Pflügler, Constantin Stautner, Anika Böttcher, Heiko Lickert, Ciro Ramirez-Suastegui, Ruhel Ahmad, Michael J. Ziller, Julia C. Fitzgerald, Viktoria Ruf, Wilma D. J. van de Berg, Allert J. Jonker, Thomas Gasser, Beate Winner, Jürgen Winkler, Daniela M. Vogt Weisenhorn, Florian Giesert, Fabian J. Theis, Wolfgang Wurst
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-25 (2022)
Here, the authors reveal using single-cell RNA sequencing that Parkinson’s disease (PD) patient-derived neuronal cells show altered primary cilia morphology and signaling suggesting cilia dysfunction may underlie PD pathogenesis.
Externí odkaz:
https://doaj.org/article/b648848b74c14840be9be48f8be10660
Autor:
Sebastian Schmidt, Malte D. Luecken, Dietrich Trümbach, Sina Hembach, Kristina M. Niedermeier, Nicole Wenck, Klaus Pflügler, Constantin Stautner, Anika Böttcher, Heiko Lickert, Ciro Ramirez-Suastegui, Ruhel Ahmad, Michael J. Ziller, Julia C. Fitzgerald, Viktoria Ruf, Wilma D. J. van de Berg, Allert J. Jonker, Thomas Gasser, Beate Winner, Jürgen Winkler, Daniela M. Vogt Weisenhorn, Florian Giesert, Fabian J. Theis, Wolfgang Wurst
Publikováno v:
Nature Communications, 13(1):4819. Nature Publishing Group UK
Schmidt, S, Luecken, M D, Trümbach, D, Hembach, S, Niedermeier, K M, Wenck, N, Pflügler, K, Stautner, C, Böttcher, A, Lickert, H, Ramirez-Suastegui, C, Ahmad, R, Ziller, M J, Fitzgerald, J C, Ruf, V, van de Berg, W D J, Jonker, A J, Gasser, T, Winner, B, Winkler, J R, Vogt Weisenhorn, D M, Giesert, F, Theis, F J & Wurst, W 2022, ' Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease ', Nature Communications, vol. 13, no. 1, 4819 . https://doi.org/10.1038/s41467-022-32229-9
Nature Communications 13(1), 4819 (2022). doi:10.1038/s41467-022-32229-9
Schmidt, S, Luecken, M D, Trümbach, D, Hembach, S, Niedermeier, K M, Wenck, N, Pflügler, K, Stautner, C, Böttcher, A, Lickert, H, Ramirez-Suastegui, C, Ahmad, R, Ziller, M J, Fitzgerald, J C, Ruf, V, van de Berg, W D J, Jonker, A J, Gasser, T, Winner, B, Winkler, J R, Vogt Weisenhorn, D M, Giesert, F, Theis, F J & Wurst, W 2022, ' Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease ', Nature Communications, vol. 13, no. 1, 4819 . https://doi.org/10.1038/s41467-022-32229-9
Nature Communications 13(1), 4819 (2022). doi:10.1038/s41467-022-32229-9
Parkinson’s disease (PD) as a progressive neurodegenerative disorder arises from multiple genetic and environmental factors. However, underlying pathological mechanisms remain poorly understood. Using multiplexed single-cell transcriptomics, we ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbbe9488b2ba42a49814c207703256ed
https://pubmed.ncbi.nlm.nih.gov/35974013
https://pubmed.ncbi.nlm.nih.gov/35974013
Autor:
Sevan Habeshian, Lukas Lercher, Ying Zhang, John W. Cuozzo, Yanbin Liu, Xia Tian, Martin Augustin, Andreas Bergmann, Stephan Krapp, Michael Mrosek, Alfred Lammens, Paolo A. Centrella, Archna Archna, Maike Däther, Marie-Aude Guié, Debora L. Konz Makino, Klaus Pflügler, Reiner Kiefersauer, Julie Liu, Klaus Maskos, John P. Guilinger, Anthony D. Keefe, Heather A. Thomson, Matthew A. Clark, Markus Siegert
Publikováno v:
Bioorganic & Medicinal Chemistry. 42:116223
Libraries of DNA-Encoded small molecules created using combinatorial chemistry and synthetic oligonucleotides are being applied to drug discovery projects across the pharmaceutical industry. The majority of reported projects describe the discovery of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef4f8e3b428396e039274205268b549
https://doi.org/10.1016/j.bmc.2021.116223
https://doi.org/10.1016/j.bmc.2021.116223