Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Klaus Pönicke"'
Autor:
Ulrich Gergs, Dorothea Ihlefeld, Tobias Clauss, Michael Weiss, Gunther O. Hofmann, Joachim Neumann, Klaus Pönicke
Publikováno v:
Clinical Pharmacology in Drug Development. 7:692-698
Patients undergoing hip or knee replacement therapy are routinely pretreated with antibiotics before they enter the operation theater. This treatment intends to reduce the incidence of peri- or postsurgical infections. Here, we calculated the uptake
Autor:
Steffen Hauptmann, Klaus Pönicke, Ulrich Gergs, Volker Otto, Henning Ebelt, Nicolas Keller, Joachim Neumann, Anne Böckler, Wilhelm Schmitz
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 386:357-367
In human atrium, serotonin (5-HT) exerts pleiotropic effects, which are thought to be mediated via 5-HT4 receptors. Here, we used transgenic mice (TG) that overexpress the human 5-HT4(a) receptor under control of the heart-specific α-myosin heavy ch
Publikováno v:
Journal of Pineal Research. 52:389-396
In this paper, we analyze the biological relevance of melatonin in diabetogenesis. As has recently been demonstrated, melatonin decreases insulin secretion via specific melatonin receptor isoforms (MT1 and MT2) in the pancreatic β-cells. In addition
Autor:
Elmar Peschke, Hans-Jürgen Brömme, Andreas Gunter Bach, Thomas Frese, Eckhard Mühlbauer, André Welp, Klaus Pönicke
Publikováno v:
Life Sciences. 85:526-533
Aims It is not well understood why the amplitude of melatonin rhythms is reduced in diabetic animals and humans. This paper addresses the differences in the pineal melatonin synthesis of type 2 diabetic Goto–Kakizaki (GK) rats compared to non-diabe
Publikováno v:
Journal of Pineal Research. 45:439-448
It is well-documented that melatonin influences insulin secretion. The effects are mediated by specific, high-affinity, pertussis-toxin-sensitive, G protein-coupled membrane receptors (MT1 as well MT2), which are present in both the pancreatic tissue
Autor:
Joachim Neumann, Klaus Pönicke
Publikováno v:
Notfall & Hausarztmedizin. 33:94-99