Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Klaus Natter"'
Autor:
Simon Arhar, Gabriela Gogg-Fassolter, Mojca Ogrizović, Klavdija Pačnik, Katharina Schwaiger, Mia Žganjar, Uroš Petrovič, Klaus Natter
Publikováno v:
Microbial Cell Factories, Vol 20, Iss 1, Pp 1-15 (2021)
Abstract Background Fatty acid-based substances play an important role in many products, from food supplements to pharmaceutical products and biofuels. The production of fatty acids, mainly in their esterified form as triacylglycerol (TAG), has been
Externí odkaz:
https://doaj.org/article/2ce18c96bd5549f68a2464c6cc3f9762
Autor:
Klavdija Pačnik, Mojca Ogrizović, Matthias Diepold, Tobias Eisenberg, Mia Žganjar, Gašper Žun, Beti Kužnik, Cene Gostinčar, Tomaž Curk, Uroš Petrovič, Klaus Natter
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-15 (2021)
Abstract Background The accumulation of intracellular fat depots is a polygenic trait. Therefore, the extent of lipid storage in the individuals of a species covers a broad range and is determined by many genetic factors. Quantitative trait loci anal
Externí odkaz:
https://doaj.org/article/1adda79b731e48e38af6e13dc17ffcd6
Autor:
Hanne Bjerre Christensen, David E. Ruckerbauer, Gunda Koellensperger, Nathan E. Lewis, Lars B. Petersen, Tim J. Causon, Klaus Natter, Christina Troyer, Sarah N. Galleguillos, Stephan Hann, Diana Széliová, Lars K. Nielsen, Nicole Borth, Dong-Yup Lee, Jürgen Zanghellini, Michael Hanscho, Harald Schoeny
Publikováno v:
Metabolic engineering. 61
Background Cell line-specific, genome-scale metabolic models enable rigorous and systematic in silico investigation of cellular metabolism. Such models have recently become available for Chinese hamster ovary (CHO) cells. However, a key ingredient, n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d6373673652ca593f924d5d026c2fe
https://pubmed.ncbi.nlm.nih.gov/32619503
https://pubmed.ncbi.nlm.nih.gov/32619503
Autor:
Klaus Natter, Simon Arhar
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1864:158513
The biosynthetic pathways for most lipophilic metabolites share several common principles. These substances are built almost exclusively from acetyl-CoA as the donor for the carbon scaffold and NADPH is required for the reductive steps during biosynt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e41f8ef2a5070ed95292a02c6d4e93e
https://doi.org/10.1016/j.bbalip.2019.08.009
https://doi.org/10.1016/j.bbalip.2019.08.009
Autor:
Govindprasad, Bhutada, Martin, Kavšček, Florian, Hofer, Gabriela, Gogg-Fassolter, Martina, Schweiger, Barbara, Darnhofer, Dušan, Kordiš, Ruth, Birner-Gruenberger, Klaus, Natter
Publikováno v:
Biochimica et biophysica acta. Molecular and cell biology of lipids. 1863(10)
Oleaginous microorganisms are characterized by their ability to store high amounts of triacylglycerol (TAG) in intracellular lipid droplets (LDs). In this work, we characterized a protein of the oleaginous yeast Yarrowia lipolytica that is associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::689772d9261f624eb3cd8510eb29e32b
https://pubmed.ncbi.nlm.nih.gov/30053597
https://pubmed.ncbi.nlm.nih.gov/30053597
Autor:
Govindprasad Bhutada, Martin Kavšček, Rodrigo Ledesma-Amaro, Stéphane Thomas, Gerald N. Rechberger, Jean-Marc Nicaud, Klaus Natter
Publikováno v:
FEMS Yeast Research. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9eb54a91fba762f34a62b2da55465a52
https://doi.org/10.1093/femsle/fox020
https://doi.org/10.1093/femsle/fox020
Sugar versus fat: elimination of glycogen storage improves lipid accumulation in Yarrowia lipolytica
Autor:
Govindprasad, Bhutada, Martin, Kavšcek, Rodrigo, Ledesma-Amaro, Stéphane, Thomas, Gerald N, Rechberger, Jean-Marc, Nicaud, Klaus, Natter
Publikováno v:
FEMS Yeast Research
Triacylglycerol (TAG) and glycogen are the two major metabolites for carbon storage in most eukaryotic organisms. We investigated the glycogen metabolism of the oleaginous Yarrowia lipolytica and found that this yeast accumulates up to 16% glycogen i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::169fe22a372da7d6eddbfc4817742be3
https://pubmed.ncbi.nlm.nih.gov/28475761
https://pubmed.ncbi.nlm.nih.gov/28475761
Autor:
Klaus Natter, Sepp D. Kohlwein
Publikováno v:
Biochimica et Biophysica Acta
One of the paradigms in cancer pathogenesis is the requirement of a cell to undergo transformation from respiration to aerobic glycolysis – the Warburg effect – to become malignant. The demands of a rapidly proliferating cell for carbon metabolit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3961a577e44f073a70bbac9912d657f5
Autor:
Sepp D. Kohlwein, Markus R. Wenk, Guanghou Shui, Thomas Dick, Wee Kiang Yeo, Klaus Natter, Srinivasa P. S. Rao, Kai Leng Low
Publikováno v:
Journal of Biological Chemistry. 285:21662-21670
Mycobacteria store triacylglycerols (TGs) in the form of intracellular lipid droplets (LDs) during hypoxia-induced nonreplicating persistence. These bacteria are phenotypically drug-resistant and therefore are believed to be the cause for prolonged t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a37f6c82c571e783967b0ae73e18c5f
https://doi.org/10.1074/jbc.m110.135731
https://doi.org/10.1074/jbc.m110.135731
Autor:
Christoph F. Kurat, Sepp D. Kohlwein, Dagmar Kolb, Guenther Zellnig, Heimo Wolinski, Klaus Natter, Julia Petschnigg
Publikováno v:
Journal of Biological Chemistry. 284:30981-30993
Storage triacylglycerols (TAG) and membrane phospholipids share common precursors, i.e. phosphatidic acid and diacylglycerol, in the endoplasmic reticulum. In addition to providing a biophysically rather inert storage pool for fatty acids, TAG synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ec1758e26ab7f58565206774a511be
https://doi.org/10.1074/jbc.m109.024752
https://doi.org/10.1074/jbc.m109.024752