Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Klaus Mendla"'
Autor:
Klaus Mendla, Andreas Raschig, Helmut Ensinger, Thomas Weiser, Wolfram Gaida, Takeshi Osugi, Angelo Ceci, Marion Wienrich
Publikováno v:
Drug Development Research. 56:321-334
Since the discovery of muscarinic receptor subtypes, extensive research has been going on attempting to provide treatments for diseases related to malfunctions of cholinergic receptors. In Alzheimer's disease, the prevailing symptomatology is a progr
Publikováno v:
European Journal of Neuroscience. 13:1644-1648
We have recently shown that in utero treatment of guinea pigs with the DNA methylating substance methylazoxymethanol acetate (MAM) results in neocortical microencephalopathy, increased protein kinase C (PKC) activity and altered processing of the amy
Publikováno v:
European Journal of Neuroscience. 12:3191-3200
Whilst it is generally accepted that the activation of protein kinase C (PKC) increases amyloid precursor protein (APP) secretion in vitro, the role of PKC in the regulation of APP processing and beta-amyloid generation in vivo is still not well unde
Autor:
Christian Haass, Harald Steiner, Martin Citron, Dennis J. Selkoe, Helmut Romig, Anja Capell, Peter M. Kloetzel, Klaus Mendla, Brigitte Pesold
Publikováno v:
Journal of Biological Chemistry. 273:32322-32331
Numerous mutations causing early onset Alzheimer's disease have been identified in the presenilin (PS) genes, particularly the PS1 gene. Like the mutations identified within the beta-amyloid precursor protein gene, PS mutations cause the increased ge
Autor:
Dennis J. Selkoe, Anja Capell, Christian Haass, Alice Schindzielorz, Brigitte Pesold, Klaus Mendla, Martin Citron, Gerd Multhaup, Jürgen Grünberg, Peter St George-Hyslop, Jochen Walter
Publikováno v:
Proceedings of the National Academy of Sciences. 94:5349-5354
The majority of familial Alzheimer disease mutations are linked to the recently cloned presenilin (PS) genes, which encode two highly homologous proteins (PS-1 and PS-2). It was shown that the full-length PS-2 protein is phosphorylated constitutively
Publikováno v:
Life Sciences. 60:985-991
Amyloid deposits in Alzheimer's disease are composed of amyloid beta-peptides (A beta) that are derived from the larger amyloid precursor protein (APP). Proteolytic APP processing is activity-dependent, and it can be regulated by muscarinic acetylcho
Autor:
Joachim Mierau, Wolf‐Dieter Bechtel, Klaus Mendla, Wolfgang Tröger, Helmut Ensinger, Franz Birke, Georg Speck
Publikováno v:
Drug Development Research. 40:144-157
The functional selectivity of WAL 2014 FU with regard to stimulation of the neuronal muscarinic M1 receptor subtype in vitro and in vivo is shown in different receptor preparations, isolated organ models, whole animal testing, and finally humans. Fro
Autor:
Gilbert Vassart, Helmut Ensinger, Jacqueline Van Sande, Frédérick Libert, Anne Lefort, Klaus Mendla, Jacques Emile Dumont, Armin Czernilofsky
Publikováno v:
Biochemical and Biophysical Research Communications. 187:919-926
A human brain hippocampus cDNA library was screened by hybridization with a dog A1 adenosine receptor cDNA probe. Sequencing of the resulting clones identified a 978 residue open reading frame encoding a 326 amino acid polypeptide showing 95.7% simil
Publikováno v:
Neuroscience Letters. 225:213-215
Consistent pathological hallmarks of Alzheimer's disease (AD) are the formation of brain amyloid and neurofibrillary tangles (NFTs). Levels of the major protein component of NFTs, the microtubule associated protein Tau, were shown to be increased in
Autor:
Klaus Mendla, Helmut Ensinger, Angelo Sagrada, Henri Doods, F.J. Kuhn, A. Immel-Sehr, Ernst Mutschler, Günter Lambrecht, G. Walther, Rudolf Hammer, R.E. Müller
Publikováno v:
Life sciences. 52(5-6)
The ability of WAL 2014 to elicit muscarinic responses was investigated in various in vitro and in vivo models. In CHO cells transfected with human m1- or m3-receptor genes, WAL 2014 was clearly more effective in stimulating the M1-mediated PI respon