Zobrazeno 1 - 10
of 224
pro vyhledávání: '"Klaus M Hahn"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 10, p e1010092 (2022)
Phagocytosis, the biological process in which cells ingest large particles such as bacteria, is a key component of the innate immune response. Fcγ receptor (FcγR)-mediated phagocytosis is initiated when these receptors are activated after binding i
Externí odkaz:
https://doaj.org/article/f7ee124af7934947bb6a3ae023d5663b
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 8, p e1006321 (2018)
Cellular morphology and associated morphodynamics are widely used for qualitative and quantitative assessments of cell state. Here we implement a framework to profile cellular morphodynamics based on an adaptive decomposition of local cell boundary m
Externí odkaz:
https://doaj.org/article/fce6057398d6444cbfe6ae4e571c48d5
A RhoC biosensor reveals differences in the activation kinetics of RhoA and RhoC in migrating cells.
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79877 (2013)
RhoA and RhoC GTPases share 92% amino acid sequence identity, yet play different roles in regulating cell motility and morphology. To understand these differences, we developed and validated a biosensor of RhoC activation (RhoC FLARE). This was used
Externí odkaz:
https://doaj.org/article/ef846e28c6c34d14bec2900571306ee0
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22025 (2011)
Focal adhesions (FAs) are macromolecular complexes that provide a linkage between the cell and its external environment. In a motile cell, focal adhesions change size and position to govern cell migration, through the dynamic processes of assembly an
Externí odkaz:
https://doaj.org/article/d24f959cbeae4fb5920eaf6839877745
Autor:
Frederico M. Pimenta, Jaewon Huh, Bryan Guzman, Diepreye Amanah, Daniel J. Marston, Nicholas K. Pinkin, Gaudenz Danuser, Klaus M. Hahn
Publikováno v:
Biophysical Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0b6a99a3efc6023ad26879f94aeaeb6
https://doi.org/10.1016/j.bpj.2023.04.020
https://doi.org/10.1016/j.bpj.2023.04.020
Autor:
Sarah Gandarillas, Valérie Choesmel-Cadamuro, Nathalie Van Acker, Camille Franchet, Y Barreira, Christele Segura, Loïc Van Den Berghe, Carine Froment, Klaus M. Hahn, Jiaying Liu, Odile Burlet-Schiltz, Andrei V. Karginov, Xiaobo Wang, Georges Czaplicki, Karine Belguise, Florence Dalenc, Lucie Chadelle
Publikováno v:
Cancer Lett
The cytoskeleton and cell-matrix adhesions constitute a dynamic network that controls cellular behavior during development and cancer. The Focal Adhesion Kinase (FAK) is a central actor of these cell dynamics, promoting cell-matrix adhesion turnover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e5c878cf45ba5f3d54a1536a6aecd4d
https://doi.org/10.1016/j.canlet.2021.11.026
https://doi.org/10.1016/j.canlet.2021.11.026
Autor:
Wesley R. Legant, Ana T. Nogueira, Yu Shi, Klaus M. Hahn, Ellen C. O’Shaughnessy, Regan P Moore, Katelyn M Heath
Publikováno v:
Lab Chip
We present a microfluidic device compatible with high resolution light sheet and super-resolution microscopy. The device is a 150 μm thick chamber with a transparent fluorinated ethylene propylene (FEP) cover that has a similar refractive index (1.3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d1486d39efad1aec8ac8aab3c211ee
https://doi.org/10.1039/d1lc00600b
https://doi.org/10.1039/d1lc00600b
Autor:
J. Cody Herron, Shiqiong Hu, Takashi Watanabe, Ana T. Nogueira, Bei Liu, Megan E. Kern, Jesse Aaron, Aaron Taylor, Michael Pablo, Teng-Leong Chew, Timothy C. Elston, Klaus M. Hahn
Podosomes are actin-enriched adhesion structures important for multiple cellular processes, including migration, bone remodeling, and phagocytosis. Here, we characterized the structure and organization of phagocytic podosomes using interferometric ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7b5911d15c9948040812227f2c39637
https://doi.org/10.1101/2022.05.04.490675
https://doi.org/10.1101/2022.05.04.490675
Autor:
Jinqi Ren, Gaudenz Danuser, Klaus M. Hahn, Mihai L. Azoitei, Jaewon Huh, Marco Vilela, Daniel J. Marston, George Glekas, John Sondek
Publikováno v:
Nature chemical biology
Here we generate fluorescence resonance energy transfer biosensors for guanine exchange factors (GEFs) by inserting a fluorescent protein pair in a structural 'hinge' common to many GEFs. Fluorescent biosensors can map the activation of signaling mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5234d2e7ee2bc25b034d05b827cded17
http://europepmc.org/articles/PMC7388658
http://europepmc.org/articles/PMC7388658
Autor:
Brian P. Mehl, Li Li, Elizabeth Hinde, Bei Liu, Christopher J. MacNevin, Chia-Wen Hsu, Enrico Gratton, Klaus M. Hahn
Most biosensors used with fluorescence lifetime imaging (FLIM) have been based on fluorescence resonance energy transfer (FRET). Here we examined the capabilities of FLIM biosensors based on environment-sensing dyes. We screened merocyanine dyes to f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c292cbe161a6d1bb6dac38dcb3358b2
https://doi.org/10.1101/2022.02.08.479035
https://doi.org/10.1101/2022.02.08.479035