Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Klaus Lindauer"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 11, Pp 1310-1322 (2021)
Abstract Writing population analysis reports that fulfilling the specifications of submission readiness is a time‐consuming process and prone to human error. Thus, there is a need to streamline the creation of these reports through elements of stan
Externí odkaz:
https://doaj.org/article/b5ec7d0ceec641d994ce42910a22bf8b
Publikováno v:
Metabolites, Vol 5, Iss 4, Pp 766-793 (2015)
The insulin-dependent activation and recycling of the insulin receptor play an essential role in the regulation of the energy metabolism, leading to a special interest for pharmaceutical applications. Thus, the recycling of the insulin receptor has b
Externí odkaz:
https://doaj.org/article/2230ebcdf5bc4e97a3e8e42a43778dfe
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 11, Pp 1310-1322 (2021)
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology
Writing population analysis reports that fulfilling the specifications of submission readiness is a time‐consuming process and prone to human error. Thus, there is a need to streamline the creation of these reports through elements of standardizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11139256a7a070040c5ba1d9c8d60a7f
https://doi.org/10.1002/psp4.12705
https://doi.org/10.1002/psp4.12705
Publikováno v:
Toxicologic Pathology. 47:634-644
Reliable detection and measurement of cell proliferation are essential in the preclinical assessment of carcinogenic risk of therapeutics. In this context, the assessment of mitogenic potential on mammary glands is crucial in the preclinical safety e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8274b1b3c7e58727fb4334f37339b35
https://doi.org/10.1177/0192623319863129
https://doi.org/10.1177/0192623319863129
Autor:
Manuela Stolte, Kerstin Wäse, Petra Scherer, Thomas Bartels, Klaus Lindauer, Nigel Roome, Martin Heinrichs
Publikováno v:
Toxicologic Pathology. 44:931-946
The toxicological profile of insulins is exclusively due to exaggerated pharmacology resulting in hypoglycemic findings. Insulin analogues displaying modifications and aimed at improving pharmacokinetics do not induce different toxicity. The main tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca94ead4edd0b6bc21e528af71c2d71
https://doi.org/10.1177/0192623316665721
https://doi.org/10.1177/0192623316665721
Publikováno v:
Metabolites
Volume 5
Issue 4
Pages 766-793
Metabolites, Vol 5, Iss 4, Pp 766-793 (2015)
Volume 5
Issue 4
Pages 766-793
Metabolites, Vol 5, Iss 4, Pp 766-793 (2015)
The insulin-dependent activation and recycling of the insulin receptor play an essential role in the regulation of the energy metabolism, leading to a special interest for pharmaceutical applications. Thus, the recycling of the insulin receptor has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb83d0baba259394b8d95b79aab092d9
http://europepmc.org/articles/PMC4693194
http://europepmc.org/articles/PMC4693194
Publikováno v:
BMC Bioinformatics. 16
Erratum After publication of the original article [1] the authors have brought to our attention that the following revisions had not been incorporated into the final published version. In Definition 1 (Petri net): “E⊆ ((P x T)∪(T x P))” is th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ea098d5f7639180e0a814d94e622fb9
https://doi.org/10.1186/s12859-015-0725-7
https://doi.org/10.1186/s12859-015-0725-7
Autor:
Jacqui Lockey, Klaus Lindauer, Ray Jupp, Elizabeth Allen, Ian Hayes, Hans-Christoph Schneider, Roger Temple, Kenny Pollock, Simon Phipps, Jeremy Fordham
Publikováno v:
Scopus-Elsevier
The increase in eosinophils at the site of antigen challenge has been used as evidence to suggest that this cell type plays a role in the pathophysiology of asthma. Aberrant production of several different cytokines, particularly interleukin (IL)-5,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b438c33f524a4638f6851c88e9f88974
https://doi.org/10.1165/ajrcmb.25.4.4456
https://doi.org/10.1165/ajrcmb.25.4.4456
Publikováno v:
Theoretical Chemistry Accounts: Theory, Computation, and Modeling (Theoretica Chimica Acta). 101:103-113
Small molecule studies indicate that C–H...X interactions (X: O,N) constitute weak H-bonds. We have performed a comprehensive analysis of their occurrence and geometry in RNA structures. Here, we report on statistical properties of the total set of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc203fcd0ee6303c63f7d90e97893bbd
https://doi.org/10.1007/s002140050415
https://doi.org/10.1007/s002140050415
Publikováno v:
Computer applications in the biosciences : CABIOS. 12(4)
The program HBexplore is a new tool for identifying and analysing H-bonding patterns in biological macromolecules. It selects all potential H-bonds according to geometrical criteria. The H-bond table can then be subjected to further automatic or inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b324e36abd1216bedeb187b73a6b11e8
https://pubmed.ncbi.nlm.nih.gov/8902354
https://pubmed.ncbi.nlm.nih.gov/8902354