Zobrazeno 1 - 10
of 282
pro vyhledávání: '"Klaus Langer"'
Autor:
Anja Feldmann, Yvonne Nitschke, Franziska Linß, Dennis Mulac, Sina Stücker, Jessica Bertrand, Insa Buers, Klaus Langer, Frank Rutsch
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16471 (2023)
Calcified aortic valve disease in its final stage leads to aortic valve stenosis, limiting cardiac function. To date, surgical intervention is the only option for treating calcific aortic valve stenosis. This study combined controlled drug delivery b
Externí odkaz:
https://doaj.org/article/03d63713732141ffae7a1eef49cb24e7
Autor:
Christina Barth, Hendrik Spreen, Dennis Mulac, Lucas Keuter, Matthias Behrens, Hans-Ulrich Humpf, Klaus Langer
Publikováno v:
Biomaterials and Biosystems, Vol 7, Iss , Pp 100057- (2022)
Externí odkaz:
https://doaj.org/article/3a693ab179d54976bca5d599dc51f81e
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11858 (2023)
Proliferating cell nuclear antigen (PCNA) is the key regulator of human DNA metabolism. One important interaction partner is p15, involved in DNA replication and repair. Targeting the PCNA–p15 interaction is a promising therapeutic strategy against
Externí odkaz:
https://doaj.org/article/7527a2f5842847089f2670d778ce43be
Autor:
Christina Barth, Hendrik Spreen, Dennis Mulac, Lucas Keuter, Matthias Behrens, Hans-Ulrich Humpf, Klaus Langer
Publikováno v:
Biomaterials and Biosystems, Vol 5, Iss , Pp 100032- (2022)
Receptor-mediated active targeting of nanocarriers is a widely investigated approach to specifically address cancerous cells and tissues in the human body. The idea is to use these formulations as drug carriers with enhanced specificity and therefore
Externí odkaz:
https://doaj.org/article/e4da2ab5791f4bbbbae81e4e2f932853
Autor:
Maria Hahn, Viktoria Lindemann, Matthias Behrens, Dennis Mulac, Klaus Langer, Melanie Esselen, Hans-Ulrich Humpf
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
Hordenine, a bioactive food compound, has several pharmacological properties and has recently been identified as a dopamine D2 receptor (D2R) agonist. Since the pharmacokinetic profile of hordenine has been described to a limited extent, the present
Externí odkaz:
https://doaj.org/article/d2b45f7325db475cb944ffb067645fd8
Autor:
Sebastian Pieper, Hannah Onafuye, Dennis Mulac, Jindrich Cinatl Jr., Mark N. Wass, Martin Michaelis, Klaus Langer
Publikováno v:
Beilstein Journal of Nanotechnology, Vol 10, Iss 1, Pp 2062-2072 (2019)
Background: Nanoparticles are under investigation as carrier systems for anticancer drugs. The expression of efflux transporters such as the ATP-binding cassette (ABC) transporter ABCB1 is an important resistance mechanism in therapy-refractory cance
Externí odkaz:
https://doaj.org/article/8d1f5de7bcb549f99a9d63b4faf90618
Autor:
Hannah Onafuye, Sebastian Pieper, Dennis Mulac, Jindrich Cinatl Jr., Mark N. Wass, Klaus Langer, Martin Michaelis
Publikováno v:
Beilstein Journal of Nanotechnology, Vol 10, Iss 1, Pp 1707-1715 (2019)
Resistance to systemic drug therapy is a major reason for the failure of anticancer therapies. Here, we tested doxorubicin-loaded human serum albumin (HSA) nanoparticles in the neuroblastoma cell line UKF-NB-3 and its ABCB1-expressing sublines adapte
Externí odkaz:
https://doaj.org/article/5689f5d2bf47444c8e464bfaf5e9ac5a
Publikováno v:
Beilstein Journal of Nanotechnology, Vol 10, Iss 1, Pp 1002-1015 (2019)
Background: When nanoparticles (NPs) are applied into a biological fluid, such as blood, proteins bind rapidly to their surface forming a so-called “protein corona”. These proteins are strongly attached to the NP surface and confers them a new bi
Externí odkaz:
https://doaj.org/article/6d8902745d9249a999eca8b981ad4477
Publikováno v:
Pharmaceutics, Vol 13, Iss 4, p 584 (2021)
Every day, thousands of patients receive erythrocyte concentrates (ECs). They are indispensable for modern medicine, despite their limited resource. Artificial oxygen carriers (AOCs) represent a promising approach to reduce the need for ECs. One form
Externí odkaz:
https://doaj.org/article/8d3c5979718b40f2905862cccc63ade9
Publikováno v:
Beilstein Journal of Nanotechnology, Vol 6, Iss 1, Pp 2504-2512 (2015)
Nanoparticles (NP) of poly(lactic-co-glycolic acid) (PLGA) represent a promising biodegradable drug delivery system. We suggest here a two-step release system of PLGA nanoparticles with a pH-tunable polymeric shell, providing an initial pH-triggered
Externí odkaz:
https://doaj.org/article/d5559daa80b34137b2d904c7a01b2b02