Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Klaus Kunath"'
Publikováno v:
Drug Development and Industrial Pharmacy. 39:402-412
Along with other options, solid dispersions prepared by spray drying offer the possibility of formulating poorly soluble drugs in a rapidly dissolving format. As a wide range of potential excipients and solvents is available for spray drying, it is u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e60e5c4f018c349eb37be85c9c23fdb
https://doi.org/10.3109/03639045.2012.685176
https://doi.org/10.3109/03639045.2012.685176
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 68:283-288
Several techniques were compared for improving the dissolution of fenofibrate, a poorly soluble drug. Particle size reduction was realized by jet milling (micronization; cogrinding with lactose, polyvinylpyrrolidone or sodium lauryl sulphate) and by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f514099969744ff9ad210789026beae0
https://doi.org/10.1016/j.ejpb.2007.05.010
https://doi.org/10.1016/j.ejpb.2007.05.010
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 68:330-337
The rate of the dissolution of four poorly soluble drugs (EMD 57033, albendazole, danazol and felodipine) was improved by cogrinding them with various excipients (lactose monohydrate, corn starch, polyvinylpyrrolidone, hydroxypropylmethyl cellulose a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e70313248a2d81674ccc6b22c9fbd3
https://doi.org/10.1016/j.ejpb.2007.05.009
https://doi.org/10.1016/j.ejpb.2007.05.009
Autor:
Karl Heinz Voigt, Thomas Merdan, Jindrich Kopecek, Thomas Kissel, Holger Petersen, Udo Bakowsky, Klaus Kunath
Publikováno v:
Bioconjugate Chemistry. 16:785-792
The influence of PEGylation on polyplex stability from poly(ethylene imine), PEI, and plasmid DNA was investigated both in vitro and after intravenous administration in mice. Polyplexes were characterized with respect to particle size (dynamic light
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83950789ce7ac9bcd49b97b58c619242
https://doi.org/10.1021/bc049743q
https://doi.org/10.1021/bc049743q
Autor:
Ulrich Bickel, Holger Petersen, Thomas Kissel, Klaus Kunath, Dagmar Fischer, Karlheinz Voigt, Anke von Harpe
Publikováno v:
Journal of Controlled Release. 89:113-125
Low-molecular-weight polyethylenimine (LMW-PEI) was synthesized by the acid-catalyzed, ring-opening polymerization of aziridine and compared with commercially available high-molecular-weight PEI (HMW-PEI) of 25 kDa. Molecular weights were determined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e7772b455b5c3f66612392c794e549
https://doi.org/10.1016/s0168-3659(03)00076-2
https://doi.org/10.1016/s0168-3659(03)00076-2
Publikováno v:
The Journal of Gene Medicine. 5:588-599
Background Targeting to integrin receptor ανβ3 by RGD peptides seems to be a promising approach for gene delivery to proliferating endothelial cells of tumor metastases. PEGylation of cationic polymers offers a reduction of non-specific binding to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::feeb9620a74014e4cc38524a7df8c4d3
https://doi.org/10.1002/jgm.382
https://doi.org/10.1002/jgm.382
Publikováno v:
Journal of Controlled Release. 88:159-172
Complexes of galactosylated polyethylenimines (gal-PEI) with DNA have been proposed for gene delivery to hepatocytes. We synthesized gal-PEI with a broad range of degrees of substitution (DS) ranging from 3.5 to 31% of all PEI amino groups by reducti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9f98c80ae67a7a473a93647c93b8a9
https://doi.org/10.1016/s0168-3659(02)00458-3
https://doi.org/10.1016/s0168-3659(02)00458-3
Autor:
Dagmar Fischer, Thomas Kissel, Clive J. Roberts, Petra M. Fechner, Holger Petersen, Snjezana Stolnik, Martyn C. Davies, Alison L. Martin, Klaus Kunath
Publikováno v:
Bioconjugate Chemistry. 13:845-854
For two series of polyethylenimine-graft-poly(ethylene glycol) (PEI-g-PEG) block copolymers, the influence of copolymer structure on DNA complexation was investigated and physicochemical properties of these complexes were compared with the results of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35fc80b45529d5f422879a91e1af4468
https://doi.org/10.1021/bc025529v
https://doi.org/10.1021/bc025529v
Publikováno v:
Pharmaceutical Research. 19:140-146
Purpose. Critical steps in the subcellular processing of poly(ethylene imine)/nucleic acid complexes, especially endosomal/lysosomal escape, were visualized by using living cell confocal laser scanning microscopy (CSLM) to obtain an insight into thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d36837623ecf43dff05111c3f7c1b541
https://doi.org/10.1023/a:1014212630566
https://doi.org/10.1023/a:1014212630566
Autor:
Klaus Kunath, Holger Petersen, Karlheinz Voigt, Ulrich Bickel, Dagmar Fischer, Anke von Harpe, Thomas Kissel
Publikováno v:
Pharmaceutical Research. 19:810-817
Purpose. To study the relationship between structure of poly(ethylene imine-co-ethylene glycol), PEI-PEG, copolymers and physicochemical properties as well as in vivo behavior of their complexes with NF-κB decoy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9be4cf77b8b1b63667838c997dced8b
https://doi.org/10.1023/a:1016152831963
https://doi.org/10.1023/a:1016152831963